Clinical trials: Calorie Restriction
Mild Cognitive Impairment, Metabolic Syndrome
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
The study explores whether selective memory complaints (SMC), mild cognitive impairment (MCI) and the comorbidity of Metabolic Syndrome symptomatic of peripheral and cerebral hypo-metabolism with corresponding epigenetic shifts…
- Trial name
- NCT03319173
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Bristlecone Health, Inc.
Nonalcoholic Fatty Liver Disease
Time Restricted Feeding on Nonalcoholic Fatty Liver Disease ( TREATY-FLD )：a 12-month Follow-up Study
Time restricted feeding (TRF) is a novel type of intermittent calorie restriction diet that involves eating a daily period of 8 hours or less.
- Trial name
- TREATY-FLD (NCT04988230)
- Testing
- Time restricted feeding, Continuous Energy Restriction
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Diet Modification
Pharmacist-led Therapeutic Nutritional Intervention in Type 2 Diabetes
Type 2 diabetes represents a significant burden to both the individual and our healthcare system. Individuals with type 2 diabetes are typically prescribed one or more glucose-lowering medications, many of which have undesirable…
- Trial name
- NCT03181165
- Testing
- Low-carbohydrate Therapeutic Nutrition
- Where
- Canada
- Volunteers
- 188 people
- Sponsor
- University of British Columbia
Breast Cancer
UCLA Breast Cancer Survivor Health Promotion Research Study
Pilot randomized controlled parallel group behavior change comparative effectiveness trial involves 30 breast cancer survivors interested in losing excess body fat.
- Trial name
- NCT05113485
- Testing
- Diabetes Prevention Program-based lifestyle change intervention (DPP), Highly Microbiota-Accessible Foods (HMAFs) intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Pre-diabetes, Older Adults
Liraglutide and a Calorie Restricted Diet Augments Weight Loss and Decreases Risk of Type 2 Diabetes and CVD.
The goal of this study is to evaluate the hypothesis that the addition of liraglutide, a long-acting glucagon-like peptide 1 (GLP-1) analogue, to a calorie-restricted diet will lead to greater weight loss than will a…
- Trial name
- NCT01784965
- Testing
- liraglutide
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Stanford University
Malignant Tumors
Restricted Calorie Ketogenic Diet as a Treatment in Malignant Tumors
Malignant tumor incidence showed an upgrade trend in recent years. Standard therapy for malignant tumor includes surgery followed by radiation and chemotherapy. Despite optimal treatment the prognosis remains poor.
- Trial name
- NCT03160599
- Testing
- ketogenic diet
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Type 2 Diabetes, Obesity, Morbid
Remission of Type 2 Diabetes Via Calorie Restriction
The primary purpose was to evaluate the efficacy of Korean low-calorie diet for obese adult patients with type 2 diabetes with a body mass index of 25 kg/m2 or higher.
- Trial name
- K-Direct1 (NCT05754775)
- Testing
- Calorie restriction via total food replacement
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Yeouido St. Mary's Hospital
Obesity, Diabetes
Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults
The investigators want to determine if the benefits of weight loss outweigh the potential risk in a group of older adults. The investigators will test the hypothesis that changes in diet composition alone or in conjunction with…
- Conditions
- Obesity, Diabetes, Hypertension, Hyperlipidemia
- Trial name
- CROSSROADS (NCT00955903)
- Testing
- Exercise, Reduced Calorie Diet, Weight Maintenance Diet
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Relapsing Remitting Multiple Sclerosis
A Pilot Study of Intermittent Calorie Restriction in Multiple Sclerosis
Experimental studies of the experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, indicate that the number of calories fed to mice prevent EAE and are also associated with less severe disease in…
- Trial name
- NCT02647502
- Testing
- Diet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Weight Management
Education Session to Improve Program Adherence
To examine is user knowledge of a dietary self-monitoring (DSM) calorie tracking app and improving patient adherence to daily caloric food intake to help with weight loss.
- Trial name
- NCT06428695
- Testing
- one-hour dietary self-monitoring tool education session
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Individuals at Risk of Developing Diabetes
Daily vs Intermittent Restriction of Energy: Controlled Trial to Reduce Diabetes Risk (DIRECT)
In this randomized controlled trial, the investigators will compare the long term effectiveness of intermittent fasting (IF) versus an energy matched moderate calorie restriction (CR) over 18 months, and relative to a non-active…
- Trial name
- NCT03689608
- Testing
- Intermittent Fasting (IF), Daily Restriction (DR), standard care (SC)
- Where
- Australia
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Aging, Metabolism
Practicality of Intermittent Fasting and Its Effect on Markers of Aging and Oxidative Stress
Healthy volunteers will be recruited to participate in a ten-week double-blinded crossover trial. The trial will consist of two, three-week periods of intermittent fasting, where subjects receive either antioxidant…
- Trial name
- NCT02132091
- Testing
- Intermittent Fasting, 400 IU Vitamin E, 1000 mg Vitamin C
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Florida
Deficiency; Calorie
Effect of 24 h Severe Energy Restriction on Appetite Regulation and Ad-libitum Energy Intake
Long term maintenance of weight loss is generally poor, which is at least partly due to increased feelings of hunger associated with restricting what can be eaten.
- Trial name
- NCT02696772
- Testing
- Energy intake
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Visceral Fat, Liver Dysfunction
Weight Loss Effect on Circulating Liver Enzymes
To investigate weight loss effect with mild calorie restriction on circulating levels of liver enzymes in nondiabetic and overweight subjects with high visceral fat area [visceral fat area (VFA) at L4 ≥ 100 cm²].
- Trial name
- NCT02992639
- Testing
- Control group, Weight loss group
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Morbid Obesity, Type 2 Diabetes Mellitus
Caloric Restriction and Insulin Secretion
Caloric restriction in obese diabetic patients quickly improves glucose control, independently from weight loss. However, the early effects of a very-low calorie diet (VLCD) on insulin sensitivity and insulin secretion in…
- Trial name
- NCT01447524
- Testing
- Very Low Calorie Diet
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Rome Tor Vergata
Healthy Volunteer
Calorie Restriction Intervention Induces Enterotype-associated BMI Loss in Nonobese Individuals
Calorie restriction (CR), which has the potential effect on weight loss and blood amino acids, has been demonstrated to associate with gut microbiota in humans, especially in obese individuals.
- Trial name
- CRDI (NCT04044118)
- Testing
- Low Calorie Diet
- Where
- China
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- BGI-Shenzhen
Intermittent Fasting, Non-Alcoholic Fatty Liver Disease
Intermittent Fasting in Nonalcoholic Fatty Liver Disease
Although preliminary evidence suggests that intermittent fasting mimic-diet (IFD) exerts stronger effects on body weight and metabolic parameters, which may link obesity, non-alcoholic fatty liver disease (NAFLD) and major…
- Conditions
- Intermittent Fasting, Non-Alcoholic Fatty Liver Disease, Insulin Resistance, Obesity
- Trial name
- NCT04355910
- Testing
- Calorie restriction
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shaoguan University
Obesity & Overweight
Effect of a High-Protein Diet With Meal Replacements on Weight Loss
The goal of this clinical trial is to learn if a structured high-protein diet with meal replacements can help with weight loss in adults with overweight or obesity.
- Trial name
- NCT07547722
- Testing
- Meal Replacement and Dietary Supplementation, Calorie-Restricted Diet
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Kazakh Academy of Nutrition
Calorie Deficiency, Fasting
Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions
The goal of this clinical trial was to identify if duration of acute calorie restriction (CR)/fasting or combination CR with cold stimuli have any effects on mental and physical health-related markers, and to clarify if different…
- Conditions
- Calorie Deficiency, Fasting, Cold Exposure
- Trial name
- NCT05545943
- Testing
- 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Ketogenic Dieting
Low Carbohydrate High Fat Ketogenic vs. Non-ketogenic Diet
The aim of this paper was to investigate and compare the effects of two iso-energetic hypo-caloric ketogenic hyper-ketonemic and non-ketogenic low carbohydrate high fat high cholesterol diets on body-composition, muscle strength…
- Trial name
- LCHF (NCT04744558)
- Testing
- Low carb high fat ketogenic dieting, Low carb high fat non-ketogenic dieting
- Where
- Serbia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Belgrade