Clinical trials: Caloric Restriction
Lipodystrophy, Diabetes
Low Energy Diet and Familial Partial Lipodystrophy
To evaluate the therapeutic efficacy and metabolic impact of a low energy diet (LED) in people with familial partial lipodystrophy and diabetes.
- Conditions
- Lipodystrophy, Diabetes, Diet Modification
- Trial name
- NCT03900286
- Testing
- Total Dietary Replacement
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Type 2 Diabetes
DiEt ChoIce to Promote Type 2 Diabetes rEmission
Type 2 diabetes is typically viewed as a chronic, progressive, and lifelong condition. Patients and their healthcare providers "manage" type 2 diabetes through lifestyle modifications and various types of medications designed to…
- Trial name
- DECIDE (NCT05710900)
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Prostatic Hyperplasia, Benign, Metabolic Syndrome
Open Randomized Clinical Trial to Evaluate the Effects of Intermittent Caloric Restriction in Patients With Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia.
Lower urinary tract symptoms (LUTS) include filling, emptying or post-voiding state alterations; producing symptomatology depending of the underline mechanism.
- Trial name
- NCT03669692
- Testing
- Caloric Restriction, Control
- Where
- Spain
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Type 2 Diabetes, Obesity, Morbid
Remission of Type 2 Diabetes Via Calorie Restriction
The primary purpose was to evaluate the efficacy of Korean low-calorie diet for obese adult patients with type 2 diabetes with a body mass index of 25 kg/m2 or higher.
- Trial name
- K-Direct1 (NCT05754775)
- Testing
- Calorie restriction via total food replacement
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Yeouido St. Mary's Hospital
Crohn's Disease
Intermittent Caloric Restriction in Patients With Mild to Moderate Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal (GI) tract. CD is a common inflammatory bowel disease (IBD), frequent (150,000 patients in France and 1.5 million in Europe), disabling and incurable.
- Trial name
- TONIC (NCT05683730)
- Testing
- Intermittent caloric restriction
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Central Hospital, Nancy, France
PreDiabetes
2-A-Day Study: Twice a Day Meals Study.
Caloric restriction increases lifespan and/or healthspan across multiple species. However implementation of long-term CR in humans is problematic and unacceptable to many individuals.
- Trial name
- NCT03809299
- Testing
- Ad libitum meal timing, Twice a day meals
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Surgical Complications
To Evaluate If Preoperative 7 Days Low Calorie Diet Reduces Postoperative Morbidity in Liver Surgery
The rationale for this study is to evaluate whether a standardized, preoperative, short-term Low Calorie Diet (LCD) reduces intraoperative bleeding and postoperative morbidity in liver surgery.
- Trial name
- LowCaLi (NCT07801716)
- Testing
- Low calorie meal replacement plan
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Type 2 Diabetes
The eHealth Diabetes Remission Trial - Pilot Study
Ten study participants will consume a low-calorie total diet replacement for 12 weeks, have a 6-week food reintroduction phase (week 13-18) and continue with the weight loss maintenance phase until the end of the study (week…
- Trial name
- eDIT-pilot (NCT04805996)
- Testing
- Diabetes remission using total diet replacement and eHealth contact with the healthcare provider
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Julia Otten
Obesity, Weight Loss
Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD
Obesity leads to physiological imbalance resulting in hyperglycemia, dyslipidaemia and inflammation and can generate systematic oxidative stress through multiple biochemical mechanisms.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05055154
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 26 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa
Weight Loss
Exercise Duration Models, in Middle-aged Men
Duration of exercise is an important factor among the medical guides for weight loss. However, there is still little knowledge about other its models in middle-aged and older men.
- Trial name
- NCT03046641
- Testing
- Continuous training, The interval training
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education
Metabolic Syndrome, Meniscus; Degeneration
Metabolic Syndrome and Degenerate Meniscus Tears
The aim is to determine the outcomes of calorie-restricted diet and exercise intervention; libitum diet and waiting list control; early arthroscopic partial meniscectomy(APM) or delayed APM effect on MetS patients with Degenerate…
- Trial name
- NCT04837456
- Testing
- Calorie restricted diet and exercise intervention, libitum diet and waiting list control group, Early arthroscopic partial menisectomy group
- Where
- China
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Jingzhou
Obesity, Insulin Sensitivity/Resistance
Energy -Sensing Metabolites in Caloric Restriction
General integrated goal of the coordinated project: To elucidate the role of succinate and other metabolites derived from the intestinal microbiota such as Short Chain Fatty Acids (SCFAs), as energy sensing metabolites in the…
- Conditions
- Obesity, Insulin Sensitivity/Resistance, Diabetes Type 2
- Trial name
- NCT05031572
- Testing
- dietary intervention
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
NAFLD, Obesity
RCT of Caloric Restriction vs. Alternate-Day Fasting in Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) in patients with diabetes (T2DM) is increasing in prevalence and can lead to cirrhosis.
- Conditions
- NAFLD, Obesity, Diabetes Mellitus, Type 2
- Trial name
- NCT03365531
- Testing
- Alternate Daily Fasting (ADF), Caloric Restriction (CR)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Florida
Urinary Incontinence, Obesity
Effect of Pelvic Floor Muscle Training on Urinary Incontinence Reports in Obese Women Undergoing a Low Calorie Diet
The purpose of this study is to assess the efficacy of pelvic floor muscle training (PFMT) on urinary incontinence reports in obese women undergoing a low calorie diet prior to bariatric surgery for obesity.
- Conditions
- Urinary Incontinence, Obesity, Strength; Pelvic Floor
- Trial name
- NCT04159467
- Testing
- Pelvic Floor Muscle Training
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Obesity
A Study To Examine The Efficacy And Safety Of Pramlintide+Metreleptin In Obese Subjects
Following screening, eligible subjects will be enrolled into a 6-week Low Calorie Diet (LCD) lead-in period. Subjects who lose at least 2% of their body weight at the end of the 6-week LCD lead-in period will be randomized to 1…
- Trial name
- NCT01235741
- Testing
- Pramlintide+Metreleptin
- Where
- 18 sites in United States
- Volunteers
- 213 people
- Sponsor
- AstraZeneca
Severe Obesity
VLCD by Enteral Route for Weight Loss
Body weight excess, from overweight to overt obesity, is associated with adverse health outcomes. In view of the time-trends of the obesity epidemic and the related cost burden, the search for effective strategies for weight…
- Trial name
- NEP (NCT01965990)
- Testing
- NEP
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- San Giuseppe Moscati Hospital
Critical Illness, ARDS
Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients
In this study, we will explore the feasibility of a randomized controlled trial that will compare high protein dose from ICU day 6 to 14 with moderate protein intake.
- Conditions
- Critical Illness, ARDS, Septic Shock, Multiple Trauma
- Trial name
- Replenish (NCT03480555)
- Testing
- Replenish Protein, Standard protein
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Abdullah International Medical Research Center
BRCA Mutation, PALB2 Gene Mutation
Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion
Circulating levels of Sex Hormone Binding Globulin (SHBG) are significantly associated with a decreased risk of breast cancer. The main aim of this clinical trial is to verify whether Low Dose Tamoxifen (LDT) increases…
- Conditions
- BRCA Mutation, PALB2 Gene Mutation, Ductal Carcinoma in Situ, Lobular Carcinoma in Situ
- Trial name
- TOLERANT (NCT06033092)
- Testing
- Tamoxifen 10 mg Tablet, Intermittent caloric restriction, Step counter Device
- Where
- 4 sites in Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Diabetes
Caloric Restriction, Exercise, and Glucoregulation in Humans
Weight loss induced by caloric restriction alone (CR) and by exercise alone (EX) result in similar effects on blood glucose and insulin.
- Trial name
- CREG (NCT00777621)
- Testing
- Calorie Restriction, Exercise, Calorie Restriction and Exercise
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Coronary Artery Disease
Time Restricted Eating and Cardiac Rehabilitation
This study will use a form of intermittent fasting called time-restricted eating (TRE) where individuals consume ad libitum energy intake within a set window of time, commonly 8 hours, which induces a fasting window of 16 hours…
- Trial name
- TREat-CR (NCT05075317)
- Testing
- Standard cardiac rehabilitation, Time-Restricted Eating
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University of Toronto