Clinical trials: Caloric Restriction
Obesity
The Addition of Probiotic Consumption to a Nutritional Intervention and Caloric Restriction on Body Weight and Composition in Overweight Participants
Limited interventional human studies suggest that probiotic supplementation may be a beneficial strategy for promoting weight loss when added to a nutritional intervention via their effects on lipid absorption and metabolic…
- Trial name
- NCT02962583
- Testing
- Weight loss, Probiotic Formula
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Laval University
Heart Failure, Diastolic, Obesity
Exercise Intolerance in Elderly Patients With Diastolic Heart Failure
The purpose of this study is to examine the effects of weight loss via hypocaloric diet, aerobic exercise training, combined hypocaloric diet and exercise training, and attention control in patients with heart failure and a…
- Trial name
- SECRET (NCT00959660)
- Testing
- Exercise, Dietary Intervention, Diet and exercise
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University
Type2diabetes
The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction
Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations.
- Trial name
- NCT05499702
- Testing
- Caloric Restriction, Hyperglycemic clamp
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Adrian Vella
Overweight and Obesity
The Effect of Very Low Calorie Diet With and Without Exercise on Muscle Synthesis in Middle-aged Overweight Male.
The aims of this project are: to investigate the impact of VLCD on control of muscle protein synthesis, muscle structure and function, cardiac function (ejection fraction), vascular function (blood flow and capillary function)…
- Trial name
- VLCDex (NCT03116256)
- Testing
- Very low calorie diet (VLCD), High intensity interval training (HIIT), Resistance exercise training (RET)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Metabolism and Nutrition Disorder, Obesity
Comparison of Liraglutide Versus Placebo in Weight Loss Maintenance in Obese Subjects: SCALE - Maintenance
This trial is conducted in North America. The aim of this clinical trial is to evaluate the potential of liraglutide to maintain long term weight loss in obese non-diabetic subjects, as well as in overweight subjects who have…
- Trial name
- NCT00781937
- Testing
- liraglutide
- Where
- 37 sites in United States, Canada
- Volunteers
- 422 people
- Sponsor
- Novo Nordisk A/S
Obesity, Morbid, Obesity
Effects of Very Low Calorie Diet vs Metabolic Surgery on Weight Loss and Obesity Comorbidities
It is a prospective randomized trial on 218 subjects, 109 for each arms. The purpose of this trial is to compare very low calorie diet and metabolic surgery induced weight loss and its maintenance.
- Conditions
- Obesity, Morbid, Obesity, Diet, Healthy, Bariatric Surgery Candidate
- Trial name
- ARGOS (NCT04583683)
- Testing
- Very low calorie diet with Fortimel (Nutricia) supplementation, Metabolic Surgery
- Where
- Italy
- Volunteers
- 218 people
- Sponsor
- Catholic University of the Sacred Heart
Metabolic Syndrome
Calorie Restricted Diet and Exercise
Calorie-restricted(CR) diet and exercise were effective to reduce Metabolic syndrome(MetS), however, its effect on knee functions for MetS patients with degenerate meniscus lesions(DMLs) was still poorly investigated.
- Trial name
- NCT05092178
- Testing
- calorie restricted diet and exercise, exercise alone
- Where
- China
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Jingzhou
Men, Diet Modification
Dietary Guide in Active Older Adult Men
The present study aimed to determine the effects of negative-calorie diet supplemented with exercise, on weight loss and lipid profile, and to compare its efficiency with low-calorie diet with exercise among elderly adult men…
- Conditions
- Men, Diet Modification, Obesity, Overweight
- Trial name
- NCT03082807
- Testing
- NCDsport, LCDsport
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education
Caloric Restriction, Body Composition
Short Term Effects of Semaglutide on Body Composition and Performance
Semaglutide, a GLP-1 receptor agonist, has demonstrated significant weight-loss effects in people with obesity and/or type 2 diabetes, but its impact on exercise performance among lean, fit athletes remains unknown.
- Conditions
- Caloric Restriction, Body Composition, Performance
- Trial name
- NCT07874971
- Testing
- Semaglutide (SEMA)
- Where
- Denmark
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Type 2 Diabetes Treated With Insulin, Diet Habit
SAFE-LCD Trial, for Insulin-treated Adults Living With Type 2 Diabetes
SAFE-LCD study is a randomised controlled trial aiming to develop and evaluate a safe, cost-effective, easily accessible, digital Low-Calorie Diet (LCD) programme for insulin-treated adults with Type 2 diabetes (T2D), a…
- Trial name
- NCT06119204
- Testing
- Oviva programme, Usual care
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Oviva UK Ltd
Osteoarthritis, Knee, Hypertension
The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot Study
Diet interventions (e.g., low-energy diets) are recommended as a treatment for obesity, obese patients with osteoarthritis, hypertension (HTN), and type 2 diabetes (T2D).
- Conditions
- Osteoarthritis, Knee, Hypertension, Type 2 Diabetes, Obesity
- Trial name
- NCT05735873
- Testing
- Low-energy diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, Morbid
Weight Loss Maintenance and Compensatory Mechanisms Activated With a Very-low Calorie Diet
Very-low calorie diets are relatively safe and effective in inducing significant weight loss, when used in selective individuals and under clinical supervision.
- Trial name
- NCT01834859
- Testing
- Multidisciplinary outpatient program, Inpatient lifestyle program
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Diabetes Mellitus Type 2, Dyslipidemia
Low Calorie Diet and Diabetes
The primary hypothesis is to investigate whether a low calorie diet for 7 weeks followed by continuous lifestyle advice is an effective option to achieve an improvement in glucose control as measured by HbA1c after 52 and 104…
- Conditions
- Diabetes Mellitus Type 2, Dyslipidemia, Non-alcoholic Fatty Liver Disease, Obesity
- Trial name
- LCD (NCT02498990)
- Testing
- Low calorie diet followed by life style intervention
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Obesity
Calories or Time Restriction to Alter Biomarkers of Aging and Diabetes
Type 2 diabetes and cardiovascular disease are an increasing problem in Australia and around the world, and are partly linked to increased rates of obesity, together with sedentary lifestyles.
- Trial name
- OMIT (NCT05769335)
- Testing
- eCR, dCR, CR
- Where
- Australia
- Volunteers
- 114 people
- Sponsor
- University of Adelaide
Obesity
Beta-glucan and Insulin Sensitivity in Obese Humans
Obesity is an important health problem of modern civilization. In Western societies, almost half of the adult population has problems with an increased body weight.
- Trial name
- NCT01393210
- Testing
- low calorie diet plus beta-glucan, low-calorie diet
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Marek Straczkowski
Obesity, Weight Loss
Weight Loss in Adults With Obesity Using a Combination of Low Energy Diet, Group Treatment and Intragastric Balloon
In Sweden, approximately 1.3 million adults have obesity. Obesity decreases quality of life (QoL) and increases the risk of diseases such as type 2-diabetes, non-alcoholic fatty liver disease (NAFLD), cancer and cardiovascular…
- Conditions
- Obesity, Weight Loss, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT04230655
- Testing
- Low energy diet using meal replacements, CBT-based group treatment, Intragastric balloon
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Region Örebro County
Obesity
Study of Changes in Skeletal Muscle After Caloric Restriction
Research has shown that fat stored within muscles affects the muscle's sensitivity to insulin and ability to handle blood glucose.
- Trial name
- NCT00993460
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Obesity, Protein-energy; Imbalance
Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity
The purpose of the study is to determine the effect of three weight loss surgeries compared to a low calorie diet with regard to energy expenditure, body composition, insulin sensitivity, and the response of gastrointestinal…
- Conditions
- Obesity, Protein-energy; Imbalance, Insulin Sensitivity, Gastrointestinal Complication
- Trial name
- BARIA (NCT00936130)
- Testing
- Laparoscopic Roux-en-Y gastric bypass, Laparoscopic gastric banding, Laparoscopic sleeve gastrectomy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Pennington Biomedical Research Center
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Acute Renal Failure
Brief Title:Effect of a Preoperative Calorie Restriction on Renal Function After Cardiac Surgery
The aim of this study is to assess the effect of a diet prior to cardiac surgery on the common postoperative decline of renal function. Until now, there is no known drug or procedure to preserve the kidneys from this impairment.
- Trial name
- CR_KCH (NCT01534364)
- Testing
- calorie restriction
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- University of Cologne