Clinical trials: Calcification
Pulpitis - Irreversible
Effectiveness of Mineral Trioxide Aggregate and Platelet Rich Fibrin Along With Biodentine. .
The aim of this study was to clinically and radiographically evaluate the effectiveness of MTA, Biodentine, Platelet Rich Fibrin along with Mineral Trioxide Aggregate and Platelet Rich Fibrin along with Biodentine as pulpotomy…
- Trial name
- NCT04773886
- Testing
- Mineral trioxide aggregate, Biodentine, Platelet rich fibrin
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Crohn Disease, Vitamin D Deficiency
Effects of Supplementation of Vitamin D in Patients With Crohn's Disease
Thus, the aim of the current study is to assess the influence of vitamin D deficiency and, consequently, of serum calcium deficiency in the body composition, muscular activity, bone mineral density, fatigue, and exercise…
- Conditions
- Crohn Disease, Vitamin D Deficiency, Fatigue, Sarcopenia
- Trial name
- NCT02704624
- Testing
- Vitamin D
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of Juiz de Fora
Vitamin D Deficiency, Injuries
Vitamin D Status Among Competitive Female Gymnast and Swimmers After Winter Time
As indoor athletes, competitive gymnasts and swimmers can face the problem of a potential vitamin D deficiency. In the last decades, indoor sports participants have been faced with the problem of an institutionalized lifestyle…
- Conditions
- Vitamin D Deficiency, Injuries, Cardiovascular Risk Factor, Nutritional Deficiency
- Trial name
- NCT03584256
- Where
- Slovenia
- Volunteers
- 31 people
- Sponsor
- University of Ljubljana
Coronary Artery Disease, Calcification
Intravascular Lithotripsy for Acute Stent Under-expansion in Calcified Coronary Lesions
Percutaneous coronary intervention (PCI) is the standard treatment for patients with coronary artery disease who have an indication for surgery.
- Trial name
- NCT06669195
- Testing
- Intravascular lithotripsy group, high-pressure balloon group
- Volunteers
- 40 people
- Sponsor
- Xuzhou Third People's Hospital
Aortic Diseases, Aorto-Iliac Atherosclerosis
Use of Shockwave M5+/L6 IVL Catheter (Intravascular Lithotripsy) in Hostile and Calcified Iliac Access
The study will evaluate, in a controlled setting, the efficacy and safety of the intravascular lithotripsy using Shockwave™ M5+/L6 Peripheral Intravascular Lithotripsy Catheter to facilitate delivery of aortic large-bore devices…
- Conditions
- Aortic Diseases, Aorto-Iliac Atherosclerosis, Peripheral Arterial Disease
- Trial name
- SHOCK-ACCESS (NCT05880641)
- Where
- 6 sites in Italy
- Volunteers
- 40 people
- Sponsor
- EndoCore Lab s.r.l.
Cerebral Palsy, Osteoporosis
Influence of Verticalization on Bone Mineral Density and Biological Parameters of Bone Remodeling in Children With Severe Cerebral Palsy
Low bone mineral density affects 77% of children with severe cerebral palsy (GMFCS IV \& V) with an increased fracture risk of 4%. One strategy supposed to improve bone mineral density is verticalisation with static devices.
- Conditions
- Cerebral Palsy, Osteoporosis, Bone Mineral Density, Bone Remodeling Disorder
- Trial name
- CPABONE (NCT04761666)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Coronary Atherosclerosis Due to Severely Calcified Coronary Lesion
The Comparison of Strategies to PREPARE Severely CALCified Coronary Lesions Trial (PREPARE-CALC)
The primary objective of this study is to evaluate the success of lesion preparation with either rotational atherectomy or cutting/scoring balloons as well as the long term effects of a hybrid sirolimus-eluting stent in an…
- Trial name
- PREPARE-CALC (NCT02502851)
- Testing
- Rotational Atherectomy, Cutting/Scoring Balloon
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Segeberger Kliniken GmbH
Chronic Kidney Disease Mineral and Bone Disorder, Renal Osteodystrophy
The Effect of Etelcalcetide on CKD-MBD
The proposed study will investigate the effects of etelcalcetide on the bone and blood-vessel health in patients with CKD-MBD. The investigators will test if etelcalcetide makes bone and blood-vessels healthier.
- Conditions
- Chronic Kidney Disease Mineral and Bone Disorder, Renal Osteodystrophy, Vascular Calcification, Hyperparathyroidism; Secondary, Renal
- Trial name
- Parsabiv-MBD (NCT03960437)
- Testing
- Etelcalcetide
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Thomas Nickolas, MD MS
Rotator Cuff Calcific Tendonitis
Ultrasound Guided Interventions of Calcific Tendonitis of Rotator Cuff (SUCTION)
The purpose of this study is to determine whether minimally invasive treatments like ultrasound guided needle fragmentation with and without lavage is associated with better clinical outcomes compared to the subacromial bursal…
- Trial name
- SUCTION (NCT02776345)
- Testing
- Ultrasound guided Needle Fragmentation, US guided needle fragmentation & Lavage, Ultrasound guided subacromial injection
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Molar Incisor Hypomineralization
Effects of Different Remineralization Agents on Molar Incisor Hypomineralization Defects: a Randomized Clinical Study
The aim of this study was to present a comparative evaluation of the long-term efficacy of fluoride varnish( Flúor protector), Clinpro™ White Varnish and pastes containing CPP-ACP in the remineralization of creamy-white and…
- Trial name
- NCT06362681
- Testing
- Fluoride
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Secondary Hyperparathyroidism, End-stage Kidney Disease
The Effect of Increasing Dialysate Calcium on T50 in Subjects With Secondary Hyperparathyroidism and ESKD
Patients with end-stage kidney disease (ESKD) have an increased risk of cardiovascular mortality. High parathyroid hormone (PTH) from secondary hyperparathyroidism leads to increased efflux of phosphate and calcium from bone…
- Trial name
- CaT50HD (NCT06398002)
- Testing
- Dialysate calcium 1.50 mmol/L
- Volunteers
- 48 people
- Sponsor
- Iain Bressendorff
Metabolic Disease
The Effect of Exercise Intervention on the Community's Older Adults
Osteoporosis is a serious global health problem, second only to cardiovascular disease. Osteoporosis is the most common metabolic bone disease in the elderly population, characterized by loss of bone mineral density (BMD) and…
- Trial name
- NCT02936336
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 411 people
- Sponsor
- Chang Gung Memorial Hospital
Scleroderma, Calcinosis Cutis
Effectiveness of ESWT and PNF in Scleroderma With Calcinosis
Investigation of the effects of ESWT and PNF exercises added to ESWT on calcinosis in Ssc patients. Calcinosis cutis is a common, difficult-to-treat manifestation of systemic sclerosis associated with high morbidity.
- Trial name
- NCT05870852
- Testing
- Extracorporeal Shock Wave Therapy (ESWT), PNF
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Coronary Arterial Disease (CAD), In Stent Restenosis
OPN Balloon for SAFE Recanalization of Calcified Coronary Lesions
The goal of the OPEN-SAFE registry is to describe the contemporary use and outcomes of SIS-OPN in North America.
- Conditions
- Coronary Arterial Disease (CAD), In Stent Restenosis, Calcified Coronary Lesions
- Trial name
- OPEN-SAFE (NCT07646444)
- Testing
- non compliant balloon
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Minneapolis Heart Institute Foundation
Primary Hyperparathyroidism
OPG/Soluble RANKL (sRANKL) and Bone Mineral Density in Primary Hyperparathyroidism
The purpose of this study is to determine whether osteoprotegerin and RANKL (receptor activator of nuclear factor-κB ligand) are involved in bone remodeling in patients with primary hyperparathyroidism (PHPT), and whether…
- Trial name
- NCT01889134
- Testing
- Sedron (alendronate), Parathyroidectomy
- Where
- Poland
- Volunteers
- 112 people
- Sponsor
- Wroclaw Medical University
Kidney Failure, Chronic, Anemia
Cholecalciferol Supplementation for Anemia and Mineral and Bone Disorder in Hemodialysis Patients
The purpose of this study is to determine whether cholecalciferol supplementation decrease the blood concentrations of hepcidin-25 in hemodialysis patients.
- Conditions
- Kidney Failure, Chronic, Anemia, Vitamin D Deficiency, Bone Diseases, Metabolic
- Trial name
- CHAMBER (NCT02214563)
- Testing
- Cholecalciferol, Olive oil
- Where
- 7 sites in Japan
- Volunteers
- 90 people
- Sponsor
- Takayuki Hamano
Reversible Pulpitis
Effect of Simvastatin as Pulpotomy Agent in Cariously Exposed Permanent Molars
The study will compare the outcome of complete pulpotomy in mature permanent mandibular molars with deep carious lesions by using Mineral Trioxide Aggregate and Simvastatin -alpha tricalcium phosphate as medicament agent
- Trial name
- NCT04374214
- Testing
- Complete Pulpotomy using Mineral Trioxide Aggregate, Complete Pulpotomy using Simvastain -alphatricalcium phosphate
- Where
- India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Sinus Floor Augmentation, Maxillary Sinus
Prospective Evaluation of Anorganic Bovine Bone Mineral Versus Calcium Phosphosilicate Alloplastic Bone Putty in Direct Sinus Augmentation: a Spilt-mouth Study
The purpose of this split-mouth clinical study is to evaluate the clinical, radiographic and histological outcomes of lateral window sinus augmentation with a bovine xenograft or a CPS putty bone substitute in posterior maxillary…
- Trial name
- NCT01942304
- Testing
- Calcium phosphosilicate alloplastic bone putty in direct sinus augmentation, Anorganic bovine bone mineral in direct sinus augmentation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Minnesota
Vascular Calcification, Hemodialysis
Analysis of the Influence of Dialysis Fluid Composition on Vascular Calcification in Patients With Chronic Kidney Disease Undergoing Hemodialysis
The goal of this clinical trial is to find out if using a citrate-based dialysate with added magnesium during hemodialysis can help slow down or prevent the hardening of blood vessels (vascular calcification) in adults on…
- Conditions
- Vascular Calcification, Hemodialysis, Cardiovascular Disease (CKD)
- Trial name
- CalCio-HD (NCT07163936)
- Testing
- Citrate dialysate with magensium supplementation, Acetate dialysate
- Volunteers
- 80 people
- Sponsor
- Hospital Clinic of Barcelona
Renal Osteodystrophy
Low Magnitude Mechanical Stimuli Effects on Bone Structure in ESRD
The proposed 6 month pilot and feasibility randomized trial will evaluate LMMS as an anabolic stimulus to bone in 30 adults on maintenance hemodialysis.
- Trial name
- NCT00364234
- Testing
- Low magnitude mechanical stimuli
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)