Clinical trials: Calcification; Heart
Coronary Artery Disease
The DANish COronary DEcalcification (DANCODE) Trial
1. Abstract Introduction Coronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction and cardiovascular mortality.
- Trial name
- DANCODE (NCT05500443)
- Testing
- Vitamin K2 (Menaquinone-7)
- Where
- 3 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease, Coronary Artery Calcification
The Efficacy and Safety of a Novel Adjunctive Pacing Strategy During Rotational Atherectomy
Coronary artery narrowings interfere with blood flow to the heart which can cause chest pain and heart attacks. Cardiologists can treat these narrowings with balloons and stents.
- Conditions
- Coronary Artery Disease, Coronary Artery Calcification, Bradycardia
- Trial name
- ROTA-PACE (NCT05404204)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Vancouver Island Health Authority
COPD, Coronary Artery Calcification
Quebec Lung Cancer Screening PLUS Trial
Does an educational intervention for untreated COPD and cardiovascular disease which is integrated in an existing lung cancer screening program improve guideline concordant medication adherence at 12 months
- Trial name
- QLC+ (NCT05444062)
- Testing
- Educational material and treatment recommendations for patients, general practitioners and pharmacists
- Where
- Canada
- Volunteers
- 330 people
- Sponsor
- Nicole Ezer, MD, FRCPC, MPH
Type 1 Diabetes, Coronary Artery Calcifications
Relation of Visceral Fat and Associated Cytokines With Early Cardiovascular Complications in Type 1 Diabetes.
Objective: To investigate whether visceral adipose tissue (VAT) and its adipokines contribute to early signs of cardiovascular disease, meaning coronary artery calcifications (CAC) and diastolic dysfunction in type 1 diabetes…
- Conditions
- Type 1 Diabetes, Coronary Artery Calcifications, Diastolic Dysfunction
- Trial name
- VISCERA (NCT02689570)
- Testing
- observational
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Angiography, Coronary Calcification
Safety and Efficacy Evaluation of Orbital Atherectomy System in de Novo Calcified Lesions
This is a French, prospective, single-arm, multi-center registry to confirm the safety and efficacy of the Diamondback 360 TM Orbital Atherectomy System in the preparation of de novo calcified coronary lesions before implantation…
- Trial name
- REFORCE (NCT05417022)
- Testing
- Diamondback 360TM orbital atherectomy system
- Where
- 17 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Recherche Cardio Vasculaire Alpes
Atherosclerosis
Strategy for Unstable Coronary Plaque in Patients Presenting to Emergency Department for Chest Pain Suspected of Coronary Artery Disease
Primary prevention of coronary disease and especially its major complication, inaugural myocardial infarction, is based on any prodromal symptoms identification and on risk profile establishment.
- Trial name
- SPECTRE (NCT06013722)
- Testing
- 18F-Na PET Scan
- Where
- Monaco
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Calcified Aortic Valve
A Prospective RegistrY of Cardiac Echographic Loops
CARDIAWAVE, a French start-up founded in 2014, aims to develop a new non-invasive therapy to treat patients suffering from Aortic Valve Stenosis (AS) who are not candidates to validated treatment of AS, i.e.
- Trial name
- ARYEL (NCT03371524)
- Testing
- Cardiac Echography
- Where
- 3 sites in France
- Volunteers
- 90 people
- Sponsor
- Cardiawave SA
Stable Angina, Coronary Artery Disease
Impact of Rotational Atherectomy on Coronary Microcirculation
The purpose of this observational study is to compare the impact of rotational atherectomy to conventional stenting and to investigate how it may affect coronary microcirculation in patients with calcified coronary artery lesions…
- Trial name
- MICRO-ROTA (NCT05771961)
- Testing
- coronary pressure/temperature sensor-tipped guidewire, Angiography-derived index of microcirculatory resistance (IMRangio)
- Where
- Lithuania
- Volunteers
- 300 people
- Sponsor
- Lithuanian University of Health Sciences
End Stage Renal Disease
Risk Factors for Coronary Artery Calcification and Left Ventricular Hypertrophy in Hemodialysis Patients
Individuals with kidney disease are at a higher risk for heart and vascular diseases, including heart attacks and strokes, than those with normal kidney function.
- Trial name
- NCT01427374
- Where
- 4 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Depression, Major Depressive Disorder
Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression
Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD.
- Conditions
- Depression, Major Depressive Disorder, Cardiovascular Disease, Coronary Artery Disease
- Trial name
- NCT00818506
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Aarhus