Clinical trials: Cachexia; Cancer
NSCLC Stage IV
Cachexia in NSCLC Patients: Diagnosis, Characterization, Prognosis, Functional and Skeletal Muscle Implications
LUCAX01 is a cohort study with patients with advanced NSCLC in tobacco users. in this study, patients will be submitted to baseline physical tests, blood and biopsy sample collection, and the main objective is to study the…
- Trial name
- LUCAX01 (NCT03960034)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Cachexia; Cancer
A Phase I Clinical Study to Evaluate the Efficacy and Safety of GB18 Injection in Patients With Tumor Cachexia
KXZY-GB18-101(1B) is an extension of KXZY-GB18-101, a first-in-human, dose-escalation trial in healthy adult participants to evaluate the safety, tolerability, PK, PD, and immunogenicity of GB18.
- Trial name
- NCT07519564
- Testing
- GB18
- Where
- 2 sites in China
- Volunteers
- 18 people
- Sponsor
- Kexing Biopharm Co., Ltd.
Cachexia
Development of a Screening Tool to Detect and Stage Cachectic Cancer Patients
The aim of the study is to develop a screenings tool that will enable hospital nurses to detect and stage cancer cachectic patients.
- Trial name
- NCT01533909
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cachexia, Rectal Cancer
Mitochondria Preservation by Exercise Training: a Targeted Therapy for Cancer and Chemotherapy-induced Cachexia
This study aims to define the contribution of cancer and chemotherapy to muscle and systemic alterations that drive the onset of cachexia in rectal cancer patients and validate in human cancer cachexia (CC) the alterations in…
- Trial name
- MEx (NCT05028192)
- Testing
- no intervention
- Where
- Italy
- Volunteers
- 144 people
- Sponsor
- University of Turin, Italy
Advanced Gastroesophageal Cancer
Clinical Study on the Treatment of Anorexia and Cachexia in Advanced Gastric and Esophageal Cancer With Nanosized Megestrol Acetate Combined With Immunochemotherapy
This study is a prospective, randomized, parallel-controlled, multicenter clinical study. The purpose of this study is to evaluate the efficacy and safety of nanocrystalline megestrol acetate combined with the first-line standard…
- Trial name
- NCT06963593
- Testing
- Nanocrystal Megestrol Acetate in Combination with First-Line Standard Immuno-Chemotherapy Regimen, First-Line Standard Immuno-Chemotherapy Regimen
- Volunteers
- 220 people
- Sponsor
- Peking University
Cancer Cachexia, Atypical Anorexia Nervosa
Cannabics Capsules as Treatment to Improve Cancer Related CACS in Advanced Cancer Patients
The main purpose in the treatment of patients with advanced cancer and cancer anorexia cachexia syndrome (CACS) is to prolong life and to improve quality of life (QoL) as far as possible.
- Trial name
- NCT02359123
- Testing
- Cannabics capsules
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Cannabics Pharmaceuticals Inc.
Anorexia
Megestrol Acetate With or Without Mirtazapine in Treating Cancer Patients With Weight Loss or Loss of Appetite
This randomized phase II trial studies the safety and efficacy of megestrol acetate given with or without mirtazapine in treating cancer patients with weight loss and loss of appetite.
- Trial name
- NCT01501396
- Testing
- Megestrol Acetate, Mirtazapine
- Sponsor
- Washington University School of Medicine
Cancer of Digestive System
Skeletal Muscle Expression of Myostatin and Cancer of Digestive System Associated Cachexia
Cancer cachexia is responsible for the death of approximately 20% of patients. Myostatin is a master negative regulator of skeletal muscle mass.
- Trial name
- MYOCAC (NCT03172403)
- Testing
- Height and weight, Blood samples, Skeletal muscle force
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Advanced Cancer, Cancer Associated Anorexia - Cachexia
Mirtazapine for Treatment of Cancer Associated Anorexia-cachexia
A randomized controlled clinical trial will be conducted to assess the efficacy of the FDA approved drug , mirtazapine , in treatment of cancer associated anorexia cachexia syndrome. Two arms will be compared .
- Trial name
- MCACS100 (NCT03254173)
- Testing
- Mirtazapine 30 mg oral tablets
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Catherine Naseef Hunter
Cachexia
Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.
The purpose of this study is to assess if Gtx-024 is effective in increasing lean body mass in subjects with muscle wasting related to cancer.
- Trial name
- NCT00467844
- Testing
- GTx-024
- Where
- 52 sites in United States, Canada
- Volunteers
- 159 people
- Sponsor
- GTx
Cachexia; Cancer, Non Small Cell Lung Cancer
A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) - 2
The goal of this clinical trial was to compare the efficacy and safety of anamorelin HCl (the investigational drug) to that of placebo (tablet with no drug) in patients with advanced non-small cell lung cancer and cachexia…
- Trial name
- NCT03743064
- Testing
- anamorelin HCl
- Where
- 65 sites in United States, Australia and 6 more
- Volunteers
- 318 people
- Sponsor
- Helsinn Healthcare SA
Cachexia, Head and Neck Cancer
Low Antioxidant Diet in Controlling Cachexia in Patients With Oropharyngeal Cancer Receiving Chemotherapy and Radiation Therapy
RATIONALE: Eating a diet that is low in antioxidants may control cachexia in patients with oropharyngeal cancer. PURPOSE: This randomized phase I trial is studying the side effects of a low antioxidant diet in controlling…
- Conditions
- Cachexia, Head and Neck Cancer, Weight Changes
- Trial name
- NCT00486304
- Testing
- ADD
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Malnutrition in Childhood, Acute Malnutrition, Severe
Reduced Dosage and/or Visitation Protocol for the Treatment of Acute Malnutrition in Kenya
Severe acute malnutrition (SAM) places children at significant risk of mortality. Outpatient treatment programs are effective but there is a need to increase treatment coverage and reduce costs of treatment.
- Conditions
- Acute Malnutrition in Childhood, Acute Malnutrition, Severe, Acute Malnutrition, Moderate, Wasting
- Trial name
- RSWITCH (NCT07420062)
- Testing
- WHO-reduced, WHO-full, Kenya-IMAM
- Where
- Kenya
- Volunteers
- 2,274 people
- Sponsor
- International Food Policy Research Institute
Metastatic (Stage IV) Non-squamous Non-small Cell Lung Cancer (Nsq-NSCLC) With Driver Gene Negativity, Untreated With Systemic Therapy
Clinical Study on Nanocrystalline Megestrol Acetate for Appetite Improvement and Weight Gain in Pre-Cachexia and Cachexia Stages Key Terminology Analysis
The purpose of this study is to evaluate the efficacy and safety of nanocrystalline medroxyprogesterone acetate for improving appetite and weight gain patients with non-small cell lung cancer (NSCLC) and cachexia and…
- Trial name
- NCT06961188
- Testing
- Nano-crystalline Megestrol Acetate Oral Suspension, Standard Therapy
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Cachexia; Cancer, Anorexia
Comparison Between Mirtazapine and Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.
Cancer-associated anorexia-cachexia is an insidious syndrome that has a major impact on the patient's quality of life, but is also associated with a significant reduction in survival.
- Trial name
- NCT03283488
- Testing
- Mirtazapine, Megestrol
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- University of Sao Paulo
Cancer
Slimming Myokines, Cancers,Nutritional and Psychology Support
With the project investigators propose, investigators aim to find answers to the following questions: The fact that irisin and atropine are slimming the proteins that cause an increase in weight loss, and the excessive wasting…
- Trial name
- NCT05278078
- Testing
- psychological support, nutritional education, psychological support and nutritional education
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ordu University
Cachexia; Cancer, Cachexia
OLE Study Subsequent to Parent Study of Rilogrotug for the Treatment of Weight Loss and Anorexia in Patients With Cancer Cachexia and mCRC or mNSCLC
The purpose of the OLE study is to evaluate the long-term safety and tolerability of rilogrotug treatment in participants who have completed the parent study and are eligible to receive continued treatment.
- Conditions
- Cachexia; Cancer, Cachexia, Cachexia-Anorexia Syndrome, Metastatic Colorectal Cancer (CRC)
- Trial name
- REACH-OLE (NCT07888075)
- Testing
- Rilogrotug
- Volunteers
- 400 people
- Sponsor
- AVEO Pharmaceuticals, Inc.
Cancer, Cachexia
A Feasibility Study of Multimodal Exercise/Nutrition/Anti-inflammatory Treatment for Cachexia - the Pre-MENAC Study
A multicentre, open, randomized phase II study comparing a multimodal intervention (oral nutritional supplements, celecoxib and physical exercise) for cachexia versus standard cancer care.
- Trial name
- NCT01419145
- Testing
- Multimodal intervention, Standard care
- Where
- 3 sites in Norway, United Kingdom
- Volunteers
- 46 people
- Sponsor
- Norwegian University of Science and Technology
Cachexia; Cancer, Diet Modification
Exercise and Nutritional Rehabilitation in Patients With Cancer
In patients with incurable cancer, general deterioration in their ability to walk, exercise and care for themselves is often regarded as an inevitable consequence of this.
- Conditions
- Cachexia; Cancer, Diet Modification, Physical Activity, Advanced Cancer
- Trial name
- ENeRgy (NCT03316157)
- Testing
- ProSure, Physical Exercise
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Leukemia, Lymphoma
Omega-3 Fatty Acids in Treating Patients With Advanced Cancer Who Have Significant Weight Loss
RATIONALE: Omega-3 fatty acids are used by the body for energy and tissue development and may be an effective treatment for patients with advanced cancer who are unable to maintain their body weight.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003077
- Testing
- omega-3 fatty acid
- Where
- 5 sites in United States
- Volunteers
- 63 people
- Sponsor
- Alliance for Clinical Trials in Oncology