Clinical trials: Cachexia; Cancer
Lung Cancer (NSCLC)
Inflammation, Cachexia and Therapeutic Response in Lung Cancer Treated With Immune Checkpoint Inhibitors: Exploratory Observational Study
Lung cancer is the leading cause of cancer-related death in France and globally, with 2.48 million new cases diagnosed in 2022, accounting for nearly 13% of global cancer incidence.
- Trial name
- LCab (NCT07004868)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Breast Cancer, Cachexia
Effect of Dietary Counseling and Nutritional Monitoring in Reducing Cancer-related Cachexia Among Female Oncology Patients
In this parallel, two-arm randomized controlled trial (RCT), 140 female patients with advanced-stage breast cancer and clinical features of cachexia will be randomized using block-stratified allocation into an intervention group…
- Trial name
- NCT07112482
- Testing
- Standard Oncological Care + Tailored Dietary Counseling + Nutritional Monitoring
- Where
- Pakistan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Pakistan Society of Pediatric Oncology
Clinical Characteristics and Treatment Outcomes of Malignant Tumor Cachexia, Multicenter Observational Study
Real-World Clinical Study for Malignant Tumor-Induced Cachexia
This study is a non-interventional, multicenter observational study, aiming to assess the clinical characteristics and treatment outcomes of malignant tumor cachexia.
- Trial name
- NCT07008248
- Where
- China
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Lung Cancer, Cachexia-Anorexia Syndrome
Nano-crystalline Megestrol Acetate for Anorexia-Cachexia Syndrome in Advanced Lung Cancer
Patients with advanced lung cancer are a high-risk population for cancer-related anorexia-cachexia syndrome (CACS). Meanwhile, the adverse reactions of chemotherapy and immunotherapy potentially exacerbate the occurrence and…
- Trial name
- NCT07092137
- Testing
- Nano-crystalline Megestrol Acetate Oral Suspension
- Volunteers
- 116 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Cancer Cachexia
Exploratory Trial of SAT-003 in Cancer Cachexia Patients With Discontinued Chemotherapy
This clinical trial aims to evaluate the feasibility of 'SAT-003' as well as its exploratory safety and efficacy in patients with cancer cachexia who have been diagnosed with solid tumors and have discontinued anticancer…
- Trial name
- NCT06476197
- Testing
- SAT-003
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- S-Alpha Therapeutics, Inc.
Non-Small Cell Lung Cancer, Cachexia
Enteral Nutrition With L-Carnitine for Cachexia in Non-Small Cell Lung Cancer
This is a multicenter, double-blind randomized controlled clinical study designed to evaluate the efficacy and safety of oral nutritional supplements (ONS) containing levocarnitine for cachexia in lung cancer patients scheduled…
- Trial name
- NCT07035444
- Testing
- L-Carnitine 4g, Enteral Nutrition
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Cancer Cachexia
PSYCHO-EDUCATIONAL AND REHABILITATIVE INTERVENTION FOR CANCER CACHEXIA (PRICC)
Half of all cancer patients experience cachexia, with the prevalence rising above 80% in the last weeks of life. The cancer cachexia is a complex relational experience which involves the dyads patients-families.
- Trial name
- NCT04153019
- Testing
- Psychoeducational and rehabilitative intervention
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Cancer Cachexia
A Phase I Study to Evaluate GFS202A in Advanced Solid Tumor Patients With Pre-cachexia or Cachexia
An open-label, multi-center, phase I study to evaluate the safety/tolerability and pharmacokinetics of GFS202A in advanced solid tumor patients with pre-cachexia or cachexia.
- Trial name
- NCT06898255
- Testing
- GFS202A injection
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Genfleet Therapeutics (Shanghai) Inc.
Geriatric Assessment, Cancer
Physical Training for Elderly Cancer Patients With Cachexia
The goal of the clinical trial is to evaluate the feasibility and efficacy of physical training for elderly cancer patients at risk of cancer cachexia.
- Conditions
- Geriatric Assessment, Cancer, Cancer Cachexia
- Trial name
- TEECH-01 (NCT05915325)
- Testing
- Physical training
- Where
- Taiwan
- Volunteers
- 23 people
- Sponsor
- National Cheng-Kung University Hospital
Extensive-stage Small Cell Lung Cancer (ES-SCLC), The Pre-cachexia or Cachexia Patients Who Have Not Received Systemic Treatment and Are Not Eligible for Curative Therapy
Nano-crystalline Megestrol Acetate Combined With Standard Treatment Versus Standard Treatment for First-line Extensive-stage Small Cell Lung Cancer in the Cachexia Phase
This study is a prospective, randomized, parallel-controlled clinical trial, aiming to evaluate the efficacy and safety of nano-crystalline megestrol acetate combined with standard treatment compared to standard treatment alone…
- Trial name
- NCT06961201
- Testing
- Nano-crystalline Megestrol Acetate Oral Suspension, standard treatment
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Cachexia, Digestive System Cancer
Real-World Study on Nano-Crystalline Megestrol Acetate for Cachexia in TKI-Treated Advanced Digestive Tumors
This study is a prospective, observational clinical study aimed at evaluating the efficacy of Megestrol Acetate for cachexia in patients with advanced digestive system tumors receiving TKI-based therapy.
- Conditions
- Cachexia, Digestive System Cancer, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT06940102
- Testing
- Nano-crystalline Megestrol Acetate Oral Suspension, TKI-Based Therapy
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Extensive-stage Small Cell Lung Cancer (ES-SCLC), Cancer - Associated Anorexia - Cachexia Syndrome
Nanocrystalline Megestrol Acetate for the Treatment of Anorexia-Cachexia Syndrome in Extensive-Stage Small Cell Lung Cancer: A Prospective, Open-Label, Single-Arm Phase II Clinical Study
Patients with extensive-stage small cell lung cancer are a high-risk group for cancer cachexia and anorexia. Meanwhile, the adverse reactions of chemotherapy and immunotherapy potentially exacerbate the occurrence and development…
- Trial name
- NCT06909383
- Testing
- Nanocrystalline megestrol acetate
- Volunteers
- 41 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Liver Cirrhosis, Cancer
Influence of Sarcopenia on the Course of the Diseases
Frailty is a geriatric syndrome that primarily affects older patients, but also patients with severe illnesses. It is particularly common among oncology patients, but also among patients with gastrointestinal diseases such as…
- Conditions
- Liver Cirrhosis, Cancer, Cachexia, Sarcopenia
- Trial name
- NCT06829290
- Testing
- Ultrasound
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Universitatsmedizin Mainz - 1. Medizinische Klinik
Non Small Cell Lung Cancer
Circulating and Molecular Markers Involved in the Processes of Cachexia, Anorexia and Sarcopenia in Patients With NSCLC
The study aim to evaluate whether some substances produced by muscle or adipose tissue may play a role in the course of the disease by interfering with the effectiveness of therapies.
- Trial name
- SARCLUNG (NCT06808113)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cachexia, Malignant Solid Neoplasm
Ultrasound in Evaluating Muscle-Glycogen Content in Cancer Patients
This trial studies how well an ultrasound procedure (non-invasive MuscleSound technology) can be used to learn about levels of glycogen (a type of sugar) in cancer patients during inpatient rehabilitation.
- Trial name
- NCT03982082
- Testing
- Physical Therapy, Questionnaire Administration, Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer, Microbiota
Microbiota and Pancreatic Cancer Cachexia
This monocentric study aims at evaluating the effects of fecal microbiota transplantation from newly diagnosed cachectic and non-cachectic pancreatic cancer patients, and healthy volunteers on several cachexia-related parameters…
- Conditions
- Pancreatic Cancer, Microbiota, Cachexia
- Trial name
- EXTRA (NCT05606523)
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Genton Graf Laurence
Locally Advanced Gastric Cancer, Trajectory
Trajectory of Body Composition Identifies LAGC with Cachexia Following NACT
This longitudinal, multicentre cohort study included LAGC patients treated with NACT between 01/2010-12/2021. BC measurements including skeletal muscle mass (SMM) and total adipose tissue area (TATA) were evaluated by computed…
- Trial name
- FJMUGS-2411 (NCT06716593)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Chang-Ming Huang, Prof.
Cancer Cachexia
EXPLORING the IMPACT of SUPERVISED PHYSICAL ACTIVITY INTERVENTION on CACHECTIC CANCER PATIENTS: a PRELIMINARY STUDY
The goal of this project is to observe the benefits induced by physical activity during a supervised adapted physical activity program at SPORMED.
- Trial name
- APACAVIR (NCT06651125)
- Testing
- Adapted Physical Activity
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University of Rennes 2
Cancer Cachexia (CC), Exercise
Assessment and Modulation of Energy Balance in Cachectic Patients Using Adapted Physical Activity
1. OBJECTIVE OF THE STUDY The study consists of evaluating resting energy expenditure (REE) and that induced by adapted physical activity (APA) in cachectic patients, compared with those predicted by equations and those of…
- Conditions
- Cancer Cachexia (CC), Exercise, Energy Regulation
- Trial name
- EMC2APA (NCT06645067)
- Testing
- Measuring energy balance
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University of Rennes 2
Sarcopenia in Elderly, Cachexia; Cancer; Sarcopenia
Body Composition in Older Adults
The primary aim of the study is to explore body composition in older adults (aged 70 years and over) with cancer, undergoing systemic anticancer treatment.
- Conditions
- Sarcopenia in Elderly, Cachexia; Cancer; Sarcopenia, Body Composition Changes, Older Adults
- Trial name
- BODI (NCT06630754)
- Testing
- No Intervention: Observational Cohort
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Marsden NHS Foundation Trust