Clinical trials: Cachexia; Cancer
Cancer Cachexia (CC), Exercise
Assessment and Modulation of Energy Balance in Cachectic Patients Using Adapted Physical Activity
1. OBJECTIVE OF THE STUDY The study consists of evaluating resting energy expenditure (REE) and that induced by adapted physical activity (APA) in cachectic patients, compared with those predicted by equations and those of…
- Conditions
- Cancer Cachexia (CC), Exercise, Energy Regulation
- Trial name
- EMC2APA (NCT06645067)
- Testing
- Measuring energy balance
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University of Rennes 2
Malnutrition, Pre-cachexia
Prevalence of Malnutrition in Oncology (PreMiO)
It is estimated that up to 30% of cancer patients die because of the effects of malnutrition, caused by a discrepancy between nutritional needs and intake (or utilization) of energy and essential nutrients.
- Conditions
- Malnutrition, Pre-cachexia, Cancer
- Trial name
- PreMiO (NCT01622036)
- Where
- Italy
- Volunteers
- 1,978 people
- Sponsor
- University of Roma La Sapienza
Cachexia; Cancer
PET Avidity in Cachexia-Inducing Lung and Gastrointestinal Tumors
PET has an established role in the initial staging of patients with newly diagnosed lung and gastrointestinal tumors.PET avidity is described with both maximum and mean standardized uptake values.Malignant cells have increased…
- Trial name
- NCT03568019
- Testing
- Retrospective study
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Cancer, Cancer Cachexia
Effects of WB-EMS and Dietetic Treatment on Cancer Patients
This study evaluates the effects of a 12-week whole-body electromyostimulation (WB-EMS) training combined with individualized nutritional support on body composition, muscle strength and function and quality of life of patients…
- Conditions
- Cancer, Cancer Cachexia, Weight Loss, Muscle Loss
- Trial name
- NCT02293239
- Testing
- Whole-Body Electromyostimulation (WB-EMS)
- Where
- Germany
- Volunteers
- 278 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cachexia, Squamous Cell Carcinoma
Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinoma
RATIONALE: Testosterone may lessen weight loss and improve muscle size and strength in patients with cachexia caused by cancer. PURPOSE: This randomized phase I trial is studying whether testosterone administered during standard…
- Trial name
- NCT00878995
- Testing
- Testosterone Enanthate 100 MG/ML
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cancer Patients With Cachexia
Evaluation of the Effects of a Mixture of Amino Acids (Amixea) on Lean Body Mass and Muscle Strengh of Patients With Unresectable Advanced Non-small Cell Lung Cancer
The primary objectives of this study are to evaluate the effects of an amino acid mixture (Amixea) on the body composition as assessed by DXA, and on QMVC as assessed by strain gauge, in advanced NSCLC patients, compared to…
- Trial name
- NCT02877966
- Testing
- Amixea
- Where
- 3 sites in Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
Cancer Cachexia
Nutrition Education and Quality of Life in Cancer Cachexia
With the project the investigators propose, the investigators aim to find answers to the following questions: Are some cachectic factors and cytokines associated with plasma level irisin in patients with advanced stage cancer…
- Trial name
- NCT05262192
- Testing
- nutrition education
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ordu University
Stage IV Gastric Cancer, Stage IIIA Gastric Cancer
A Study of Creatine Combined With Curcumin in the Intervention of Early Cachexia in Upper Gastrointestinal Tumors
Cachexia is a common complication of various advanced malignant tumors, which seriously affects the quality of life and survival time of patients.
- Conditions
- Stage IV Gastric Cancer, Stage IIIA Gastric Cancer, Stage IIIB Gastric Cancer, Stage III Esophageal Cancer
- Trial name
- NCT05856500
- Testing
- basic nutrition, oral supplement of creatine and curcumin
- Volunteers
- 152 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Advanced Malignant Solid Neoplasm, Caregiver
Frequency of Cachexia in Ambulatory Cancer Patients and Psychological Burden in Patients and Their Primary Caregivers
This trial studies the frequency of cachexia in ambulatory cancer patients and the psychological burden in patients and their primary caregivers who are referred to an outpatient supportive care clinic.
- Conditions
- Advanced Malignant Solid Neoplasm, Caregiver, Metastatic Malignant Solid Neoplasm, Recurrent Leukemia
- Trial name
- NCT04090619
- Testing
- Questionnaire Administration
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Pancreatic Cancer, NSCLC, Metastatic
Patient Reported Outcomes Registry in Patient With Cancer Cachexia
Evaluation of patient reported outcomes (PRO) with tumor cachexia in a real life setting.
- Trial name
- PROXie (NCT02983500)
- Where
- Germany
- Volunteers
- 253 people
- Sponsor
- iOMEDICO AG
Cancer Cachexia
A First in Human Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics Effects of OC514
Oncocross is developing OC514, a drug-drug combination product containing 2 active pharmaceutical ingredients for cancer cachexia.
- Trial name
- NCT05264038
- Testing
- OC514 (Low dose), OC514 (Mid dose), OC514 (High dose)
- Where
- Australia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Oncocross Australia Pty Ltd.
Brain Tumor, Central Nervous System Tumors
Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment
RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in children with cancer. PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in improving appetite and…
- Conditions
- Brain Tumor, Central Nervous System Tumors, Cachexia, Leukemia
- Trial name
- NCT00066248
- Testing
- cyproheptadine hydrochloride, megestrol acetate
- Where
- 43 sites in United States, Canada and 1 more
- Volunteers
- 70 people
- Sponsor
- University of South Florida
Cachexia
Clinical Study of BYM338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas
A safety \& efficacy clinical study of the investigational medicinal product BYM338 for the treatment of unintentional weight loss in patients with cancer of the lung or the pancreas
- Trial name
- NCT01433263
- Testing
- BYM338 active drug
- Where
- 10 sites in United States, Lithuania and 3 more
- Volunteers
- 57 people
- Sponsor
- Novartis Pharmaceuticals
Locally Advanced Gastric Cancer, Trajectory
Trajectory of Body Composition Identifies LAGC with Cachexia Following NACT
This longitudinal, multicentre cohort study included LAGC patients treated with NACT between 01/2010-12/2021. BC measurements including skeletal muscle mass (SMM) and total adipose tissue area (TATA) were evaluated by computed…
- Trial name
- FJMUGS-2411 (NCT06716593)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Chang-Ming Huang, Prof.
Neoplasm Metastasis, Bone Neoplasms
The Palliative Radiotherapy And Inflammation Study - PRAIS
Radiation therapy (RT) is one of the primary treatments for bone cancer pain due to metastatic cancer disease. About 6 of 10 patients obtain pain relief from RT.
- Trial name
- PRAIS (NCT02107664)
- Testing
- Palliative RT for bone cancer pain
- Where
- 3 sites in Norway
- Volunteers
- 580 people
- Sponsor
- Norwegian University of Science and Technology
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cancer, Cachexia
TuLip : Role of the Tumor Environment in Cancer-related Fat Loss
Cancer cachexia is defined as a weight loss of more than 5% over the last 6 months, a loss of body fat and muscle atrophy. It is found in 80% of patients with advanced cancer.
- Conditions
- Cancer, Cachexia, Adipose Tissue
- Trial name
- TuLip (NCT05128318)
- Testing
- Nissen Fundoplication, cholecystectomy
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Université Catholique de Louvain
Cachexia, Non-Small Cell Lung Cancer
Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 1)
The administration of Anamorelin in patients with Stage III-IV non-small cell lung cancer-cachexia (NSCLC-C) is expected to increase appetite, lean body mass, weight gain, and muscle strength.
- Trial name
- NCT01387269
- Testing
- Anamorelin HCl
- Where
- 60 sites in United States, Belarus and 14 more
- Volunteers
- 484 people
- Sponsor
- Helsinn Therapeutics (U.S.), Inc
Cancer Cachexia
Pilot Clinical Trial of Repeated Doses of Macimorelin to Assess Safety and Efficacy in Patients With Cancer Cachexia
The purpose of this study is to evaluate the safety and efficacy of repeated oral administration of macimorelin at different doses daily for 1 week for the treatment of cancer cachexia.
- Trial name
- NCT01614990
- Testing
- Macimorelin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Garcia, Jose M., MD, PhD
Anorexia
Olanzapine Anorexia Cachexia
164 patients will be recruited..Adult patients diagnosed with incurable solid tumors and CCAA who presented to Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine (NEMROCK) - Kasr Al-Ainy School of Medicine - Cairo…
- Trial name
- NCT05243251
- Testing
- Olanzapine 5 MG
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Cairo University