Clinical trials: CVD
Stroke
Vibroacoustic Therap in Patients With Stroke
PURPOSE: to investigate the effect of vibroacoustic therapy device with laser motion guidance affect balance sensory integration in patients with stroke BACKGROUND: Following stroke, motor recovery can be dictated by the degree…
- Trial name
- NCT07206485
- Testing
- vibro-acoustic therapy, Motion Guidance Laser, selected physical therapy exercises program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- October 6 University
Congenital Heart Disease (CHD), Ventricular Septal Defects (VSD)
Early Warning of Structural Complications in Perimembranous VSD
The goal of this observational study is to develop and test a AI-based prediction model for children with perimembranous ventricular septal defect, also called PMVSD.
- Trial name
- NCT07662343
- Where
- China
- Volunteers
- 11,683 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Chronic Obstructive Pulmonary Disease, Heart Failure
PATient Navigator to rEduce Readmissions
Staying out of the hospital is valued by patients and their caregivers. Their interests converge with those of hospitals now that high 30-day readmission rates for some conditions place hospitals at risk for financial penalties…
- Conditions
- Chronic Obstructive Pulmonary Disease, Heart Failure, Sickle Cell Disease, Myocardial Infarction
- Trial name
- PArTNER (NCT02114515)
- Testing
- Hospital usual care, Navigator intervention, Peer-led telephone support line
- Where
- United States
- Volunteers
- 1,029 people
- Sponsor
- University of Illinois at Chicago
Therapy Refractory Myocardial Ischemia, Coronary Artery Disease
Improvement of Myocardial Blood Flow by PhosphoDiesterase 5 Inhibition in Coronary Artery Disease
The aim of this study is to prospectively investigate if intermittent Phosphodiesterase 5 inhibition for 15 weeks improves myocardial perfusion by angiogenesis in patients with therapy refractory myocardial ischemia due to…
- Conditions
- Therapy Refractory Myocardial Ischemia, Coronary Artery Disease, Unsuitable for Surgical or Percutaneous Revascularisation
- Trial name
- SYDNEY (NCT01406535)
- Testing
- Vardenafil
- Where
- Austria
- Sponsor
- Medical University of Vienna
Pulmonary Hypertension
Non-interventional Multi-center Study on Patients Under Routine Treatment of Pulmonary Arterial Hypertension (PAH) With Inhaled Iloprost Using I-Neb as a Device for Inhalation
This pilot, non-interventional, company-sponsored, multi-center study documents observational data on patients under routine treatment of Pulmonary Arterial Hypertension (PAH) with inhaled iloprost (using I-Neb device for the…
- Trial name
- COMPHI (NCT01894035)
- Testing
- Iloprost (Ventavis, BAYQ 6256)
- Where
- Portugal
- Volunteers
- 13 people
- Sponsor
- Bayer
Autoimmune Autonomic Ganglionopathy (AAG)
Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy
The purpose of the study is to see if administering intravenous immune globulin (IVIG) (putting immune globulin directly into your blood) helps to improve the symptoms of orthostatic hypotension (sudden fall in blood pressure…
- Trial name
- NCT01522235
- Testing
- Double blinded IVIg, Single Blinded IVIg
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Coronary Artery Disease, Angina Pectoris
The OCT SORT-OUT VIII Study
The purpose of this study is to compare early vessel healing after implantation of SYNERGY drug eluting stent (DES) or BioMatrix NeoFlex DES at one and three months in two cohorts.
- Conditions
- Coronary Artery Disease, Angina Pectoris, Myocardial Infarction
- Trial name
- OCT SORT-OUT (NCT02253108)
- Testing
- Everolimus eluting bioresorbable polymer stent, Biolimus eluting bioresorbable polymer stent
- Where
- 2 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- Aarhus University Hospital Skejby
Coronary Artery Disease
Improving Adherence to Post PCI Antiplatelet Therapy in Minority Populations
The purpose of this study is to evaluate if the use of a phone based motivational interviewing among minority populations who received a coronary stent can improve adherence to antiplatelet agents from approximately 51% to 66%…
- Trial name
- NCT01651208
- Testing
- Motivational Interviewing (MINT), Mailed DVD
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- University of Miami
Endocarditis, Bacterial, Aneurysm, Intracranial Mycotic
Neurological Complication of Infective Endocarditis: A Prospective Multi-site Cohort Study
The main objective of this study is to better estimate the rate of infectious intracranial aneurysms (IIA) in proved infective endocarditis (IE).
- Trial name
- NCT05152225
- Testing
- Brain MRI, digital subtraction angiography (DSA)
- Volunteers
- 200 people
- Sponsor
- the Jeunes en Neuroradiologie Interventionnelle (JENI) research group
Cardiogenic Shock, STEMI
Incorporating Supersaturated Oxygen in Shock
A multi-center, prospective randomized (1:1) pilot and feasibility study to evaluate the safety and feasibility of supersaturated oxygen (SSO2) therapy delivered for 60 minutes selectively into the culprit coronary artery of…
- Trial name
- ISO-SHOCK (NCT04876040)
- Testing
- SSO2 Downstream System, PCI + Impella
- Where
- 7 sites in United States
- Sponsor
- TherOx
Heart Failure
Dapagliflozin in Diabetic Patients (Type 2) With Decompensated Heart Failure
We hypothesize that Dapagliflozin could improve the diuretic response in diabetic patients with acute decompensated heart failure owing to its diuretic effect in addition to improvement of blood glucose level without remarkable…
- Trial name
- NCT04385589
- Testing
- Dapagliflozin, insulin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Multiple Myeloma
A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma
This Phase Ib, multicenter, open-label study will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cevostamab monotherapy, cevostamab plus pomalidomide and dexamethasone (Pd) or cevostamab…
- Trial name
- CAMMA 1 (NCT04910568)
- Testing
- Cevostamab, Tocilizumab, Pomalidomide
- Where
- 34 sites in United States, Australia and 11 more
- Volunteers
- 186 people
- Sponsor
- Genentech, Inc.
Stroke, Ischemic, Atrial Fibrillation
Left Atrial Appendage Closure by Surgery-2
Atrial fibrillation is a heart rhythm disorder that often occurs after heart surgery. During atrial fibrillation blood cloths may form, predominantly in the left atrial appendage, a small sac in the wall of the left side of the…
- Trial name
- LAACS-2 (NCT03724318)
- Testing
- closure of the left atrium appendage
- Where
- 4 sites in Denmark, Spain and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Helena DOMINGUEZ
Rheumatoid Arthritis
Clinical Study Evaluating the Effect of Carvedilol in Patients With Active Rheumatoid Arthritis
This study aims at investigating the possible efficacy and safety of carvedilol as an adjunctive therapy in patients with active rheumatoid arthritis and hypertension.
- Trial name
- NCT06108518
- Testing
- Carvedilol
- Volunteers
- 70 people
- Sponsor
- Tanta University
Stroke, Ischemic, Aphasia
pBFS-guided cTBS Over the Superior Temporal Gyrus for Aphasia After Ischemic Stroke
The objective of this trial is to evaluate the effectiveness and safeness of continuous Theta Burst Stimulation (cTBS) over the right Superior Temporal Gyrus (STG), guided by personalized Brain Function Sector (pBFS) technology…
- Trial name
- NCT05999318
- Testing
- active continuous Theta Burst Stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Changping Laboratory
Congestive Heart Failure
Study of Sildenafil in Advanced Heart Failure.
Despite advances in medical therapy for patients with heart failure, one-third of patients remain limited by fatigue and shortness of breath.
- Trial name
- NCT00309790
- Testing
- sildenafil
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Pulmonary Hypertension
Prognostic Value of Vitamin D and Intact Parathyroid Hormone (iPTH) in Pulmonary Hypertension
The aim of this observational study is to analyse the prognostic value of 25(OH)-vitamin D, iPTH and other serum biomarkers in patients with pulmonary hypertension.
- Trial name
- NBHAP (NCT06872710)
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Heart Failure
Next-generation, Integrative, and Personalized Risk Assessment to Prevent Recurrent Heart Failure Events: the ORACLE Study
The aim of this study is to develop and validate an improved, comprehensive risk assessment algorithm integrating blood RNA-based biomarkers, clinical, and patient-centered data and to assess the incremental predictive value…
- Trial name
- ORACLE (NCT05679713)
- Testing
- Comprehensive risk assessment algorithm
- Where
- Spain
- Volunteers
- 1,134 people
- Sponsor
- Hospital Universitari de Bellvitge
Stroke
Cognitive Training After Stroke : Effects and Mechanisms
Stroke is a major cause of severe cognitive and physical disability. Despite the high and increasing incidence, and large health, economic, social and personal consequences, studies designed to remedy cognitive impairments and…
- Trial name
- NCT04932304
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Oslo University Hospital
ICAS - Intracranial Atherosclerosis
IntraCranial Angiography-derived Fraction Flow-guided Percutaneous Transluminal Angioplasty and Stenting Versus Medical Therapy (ICAS-MT)
A multicenter, open-label, blinded-endpoint, prospective, randomized controlled clinical trial with an "all comers" design.
- Trial name
- NCT05974033
- Testing
- Stenting plus medical therapy, Medical therapy alone
- Volunteers
- 536 people
- Sponsor
- Changhai Hospital