Clinical trials: CT Angiography
Coronary Artery Disease (CAD), Computed Tomography Angiography
AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)
The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated…
- Conditions
- Coronary Artery Disease (CAD), Computed Tomography Angiography, Biomarkers, AI (Artificial Intelligence)
- Trial name
- ACTION (NCT07577609)
- Where
- Ireland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Galway
Coronary Artery Disease, Atherosclerosis
Coronary Artery Geometry and the Severity of Coronary Atherosclerosis
The purpose of this study is to investigate the potential association of coronary artery geometry, based on coronary CT angiography (CCTA), with the complexity and the severity of coronary atherosclerosis.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Atherosclerotic Plaque, Stable Angina
- Trial name
- GEOMETRY-CTA (NCT04185493)
- Testing
- CCTA
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Coronary Artery Disease
CCTA-FFR Registry for Risk Prediction
The investigators sought to investigate the prognostic implication of qualitative and quantitative plaque analysis on coronary CT angiography (CCTA) according to fractional flow reserve (FFR).
- Trial name
- NCT04037163
- Testing
- Fractional flow reserve, Coronary CT angiography
- Volunteers
- 747 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Clinical Impact of Cardiac Photon-Counting Detector CT
The purpose of this research trial is to determine whether images taken using a Photon Counting Detector CT scanner (PCD-CT) provide clinically important information about the severity of suspected coronary artery disease and…
- Trial name
- NCT05240807
- Testing
- Photon-counting detector computed tomography (PCD-CT)
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Mayo Clinic
Radiation Injury
Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level
The clinically widely used X-ray computed tomography examination has a low-grade radiation effect and recently has attracted much attention concerning the possible adverse effects of radiation on human body [ref. 1-5].
- Trial name
- NCT00815230
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Stroke
Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis- (ATTEST)
A pilot evaluation of tenecteplase compared to alteplase in acute ischaemic stroke patients currently eligible for intravenous alteplase treatment in a prospective, randomised, blinded outcome evaluation clinical trial using…
- Trial name
- ATTEST (NCT01472926)
- Testing
- Tenecteplase, alteplase
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- NHS Greater Glasgow and Clyde
Heart Valve Diseases, Coronary Artery Disease
coRonary assEssment of Preoperative vaLvulopathy pAtients Using ComputEd Tomographic Angiography (REPLACE)
Preoperative detection of combined coronary artery disease by invasive coronary angiography (ICA) is recommended in American Heart Association (AHA)/American College of Cardiology (ACC) guidelines for most patients (>40 yrs male…
- Trial name
- REPLACE (NCT02632617)
- Testing
- Computed tomographic angiography
- Where
- 5 sites in China
- Volunteers
- 2,644 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Pulmonary Embolism
Use of Gadolinium in CT Pulmonary Angiography
The study will investigate patients with clinical suspicion for pulmonary embolism (PE) who have a contraindication to iodine based contrast.
- Trial name
- NCT02234375
- Testing
- Gadolinium
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Impact of Coronary CT Angiography, Physiologic Assessment and Pharmacotherapy on the Clinical Outcomes
The investigators aim to investigate the prognostic implication of stenosis and plaque features on coronary CT angiography (CCTA), physiologic assessment, and pharmacotherapy after invasive coronary angiography.
- Trial name
- PRIME-CT (NCT04547231)
- Testing
- Fractional flow reserve, Coronary CT angiography
- Where
- South Korea
- Volunteers
- 992 people
- Sponsor
- Seoul National University Hospital
Peripheral Artery Disease
Predicting Outcomes of PAD Patients Undergoing Endovascular Intervention With CTA
Lower extremity peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular morbidity following coronary artery disease and stroke, affect 200 million people worldwide and is associated with high…
- Trial name
- NCT03974880
- Where
- China
- Volunteers
- 480 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Coronary Artery Disease, Coronary Stenosis
The PICCOLETO XIII REVEAL-DCB Cohort A Study
To characterize, using paired coronary computed tomography angiography (CCTA), longitudinal changes in coronary atherosclerotic plaque, lumen dimensions, and vessel remodeling between baseline and mid-term follow-up in de novo…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Coronary Restenosis, Coronary Atherosclerosis
- Trial name
- REVEAL-DCB-A (NCT07868523)
- Volunteers
- 200 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Coronary Artery Disease
Silicon-based Photon Counting Computed Tomography for Advanced Cardiac Imaging
Computed tomography (CT) is a key imaging modality, with rapidly increasing use in cardiovascular diagnostics. Coronary CT angiography (CCTA) provides high-resolution, non-invasive assessment of coronary anatomy and is now…
- Trial name
- SILIC-HEART (NCT07411196)
- Testing
- Photon-counting computed tomography
- Volunteers
- 1,000 people
- Sponsor
- Ronny R Buechel, MD
Coronary Disease
Prospective Randomized Trial On RadiaTion Dose Estimates Of CT AngIOgraphy In PatieNts Scanned With A 100kV Protocol
The objective of this study is to compare radiation dose of a 100kV scan protocol to the standard 120kV scan protocol. We hypothesize that the 100kV scan protocol is associated with a reduction in dose estimates of at least 20%…
- Trial name
- PROTECTION-II (NCT00611780)
- Testing
- tube voltage
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Chronic Total Occlusion of Coronary Artery
CT Coronary Angiography Prior to CTO PCI
A Chronic Total Occlusion or CTO of a coronary artery is a an artery that has been blocked for >/= 3 months. More than a decade ago, patients with such coronary artery blockage would have been sent for Coronary Artery Bypass…
- Trial name
- NCT05364827
- Testing
- CTCA
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Coronary Artery Disease
Diagnostic Performance of Fractional Flow Reserve Derived From Coronary CT Angiography
This is a blind evaluation, self-control, multicenter clinical trial designed to determine the diagnostic performance of CT-FFR from coronary computed tomographic angiography (CCTA), as compared to CCTA alone, for non-invasive…
- Trial name
- ACCURATE-CT (NCT04426396)
- Testing
- FFR
- Where
- China
- Volunteers
- 339 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lipidemia, Coronary Artery Disease
A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque
This placebo-controlled, double-blind, randomized, Phase 3 study is being conducted in adult participants with high-risk atherosclerotic cardiovascular disease (ASCVD) who are not adequately controlled by their maximally…
- Conditions
- Lipidemia, Coronary Artery Disease, Plaque, Atherosclerotic
- Trial name
- REMBRANDT (NCT06305559)
- Testing
- obicetrapib 10 mg + ezetimibe 10 mg FDC daily
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- NewAmsterdam Pharma