Clinical trials: CT
Coronary Artery Disease, Atherosclerosis
PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]
Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Coronary Atherosclerosis of Native Coronary Artery
- Trial name
- PET; CT (NCT05994014)
- Testing
- PET/CT
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Johns Hopkins University
Cushing Syndrome
Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT
The incidence of Cushing syndrome (CS) is 1.2-3.2 cases per million per year, of which adrenocorticotropic Hormone (ACTH)-dependent disease comprises approximately 70-80% of cases.
- Trial name
- Ga-68 mDesmo (NCT06962202)
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Coronary; Ischemic
Follow-up With CT-FFR in CHD Patients After DCB
In recent years, based on CCTA data, CT-derived fractional flow reserve (CT-FFR) developed by artificial intelligence and other technologies can provide both anatomical and functional information of coronary artery disease.
- Trial name
- NCT04664439
- Testing
- CT-FFR
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Hospital
Lung Cancer
Use of Integrated PET/CT as a First Line Staging and Re-staging Technique in Oncologic Patient.
Positron emission tomoscintigraphy (PET) and contrast computed tomography (CTmdc) are diagnostic methods widely used in the staging and restaging of neoplastic diseases.
- Trial name
- NCT06168877
- Testing
- Execution of 18F-FDG PET/CT and contrast-enhanced CT scan.
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Angiogenic Breast Cancer
Safety and Efficacy of Ga68-IAC PET/CT for Diagnosis and Clinical Management in Metastatic Breast Cancer Patients
This is a phase I/IIa, open label, multicenter interventional study of Gallium-68 radiolabeled Integrin Adhesion Complex antagonist conjugate (Ga-68-IAC) Positron Emission Tomography (PET/CT) imaging, intended for diagnosis, and…
- Trial name
- Shiva (NCT04480619)
- Testing
- Ga-68-IAC
- Where
- 3 sites in India, South Africa
- Volunteers
- 25 people
- Sponsor
- Advanced Imaging Projects, LLC
Lung Cancer
Added Value of PET/CT in Lung Cancer
Assess the value of PET/CT in the diagnosis, staging, response evaluation, and relapse monitoring of lung cancer.
- Trial name
- NCT06494800
- Testing
- True cut needle biobsy
- Volunteers
- 30 people
- Sponsor
- Sohag University
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cervical Cancer
Para Aortic Lymphadenectomy : Always ?
Cervical cancer affects more than 3000 new cases per year in France. The treatment of stage IB3 to IVA cervical cancer is based on concomitant radio-chemotherapy.
- Trial name
- PALA (NCT04392895)
- Testing
- Para Aortic Lymphadenectomy (PAL) by laparoscopy
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Montpellier
Thoracic Malignancies
CT-Guided Adaptive Radiation Therapy Combine With Anti-PD-1 Antibody Adjuvant Immunotherapy for Thoracic Cancer Patients
This phase II study is to evaluate the safety and efficacy of CT-based adaptive radiation therapy followed by adjuvant anti-PD-1 antibody immunotherapy in treating patients with different types and stages of thoracic…
- Trial name
- CARTAI (NCT03732430)
- Testing
- IBI308
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Taizhou Hospital
ARDS (Moderate or Severe)
FAPI PET/CT to Detect Fibroblast Activity in Non-resolving ARDS
Of patients requiring mechanical ventilation in the ICU 23% meet criteria of the Acute Respiratory Distress Syndrome (ARDS). Mortality of this syndrome remains high (35-46%) in moderate and severe ARDS.
- Trial name
- FAPI ARDS (NCT06691464)
- Testing
- PET
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Non-Small Cell Lung Cancer (NSCLC)
FDG PET/CT in Lung Cancer Staging
Prospective study of the effects of image acquisition and reconstruction parameters on accuracy of FDG PET/CT mediastinal nodal staging in NSCLC
- Trial name
- NCT02738398
- Testing
- FDG PET/CT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Neoplasms
18F-FAPI-RGD PET/CT in Various Tumor Types
The clinical feasibility of 18F-FAPI-RGD PET/CT will be evaluated in 100 patients with various types of tumor, and the results will be compared with those of 18F-FDG.
- Trial name
- NCT06094530
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Cirrhosis, Liver, Hepatocellular Carcinoma
CT-guided Localization for Micro Hepatocellular Carcinoma Before Surgical Resection
In this project, the preoperative anatomical location of micro hepatocellular carcinoma under the guidance of CT can provide guidance for accurate surgical resection.
- Trial name
- CTMH (NCT05433467)
- Testing
- CT-guided localization for micro hepatocellular carcinoma before surgical resection
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Northern Jiangsu People's Hospital
Lung Cancer Screening
Lung Cancer Screening by Low Dose CT Scan in a French Department (DEP KP80)
Lung cancer is the leading cause of cancer death worldwide. The aims of this study were to assess the feasibility and effectiveness of a lung cancer screening pilot program with LD CT scan in a French department (Somme).
- Trial name
- NCT03853967
- Testing
- Low dose CT scan
- Where
- France
- Volunteers
- 1,307 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier d'Abbeville
Medullary Thyroid Carcinoma
Head-to-head Study of 68Ga-MGS5 Versus 68Ga-DOTATATE PET/CT in Patients With Medullary Thyroid Carcinoma
Cholecystokinin-2 (CCK2) receptor is overexpressed in more than 90% of MTC cases, and preclinical studies have shown that 68Ga-MGS5 (targeting CCK2) has good stability in vivo and is promising for diagnosis and staging of MTC.
- Trial name
- NCT06520319
- Testing
- 68Ga-MGS5
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Advanced Adult Primary Liver Cancer, Liver Metastases
Pilot Study to Assess Lung Shunting of Yttrium-90 Microspheres Using PET/CT
This pilot clinical trial studies positron emission tomography (PET)/computed tomography (CT) in finding beads after Yttrium-90 bead therapy in patients with primary liver cancer or cancer that has spread to the liver…
- Conditions
- Advanced Adult Primary Liver Cancer, Liver Metastases, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT02119065
- Testing
- positron emission tomography, computed tomography
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Cincinnati
Chest Pain, Coronary Artery Disease
Coronary Computed Tomographic Angiography Combined With CT-FFR in Intermediate-Risk Chest Pain Patients.
This study aims to investigate the guiding value of coronary CTA combined with CT-FFR in diagnostic and treatment decision-making for emergency chest pain patients at moderate risk, as well as its impact on clinical outcomes.
- Conditions
- Chest Pain, Coronary Artery Disease, Emergency Department
- Trial name
- E-CCTA (NCT07140419)
- Testing
- Coronary computed tomographic angiography with CT - derived fractional flow reserve
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Qilu Hospital of Shandong University
Healthy Volunteers (HV)
An Open-Label PET/CT Imaging Study to Evaluate Brain Serotonin Transporter (SERT) Occupancy Following Single-Dose Administration of LG-0317 Tablets in Healthy Participants
The purpose of the study is to evaluate brain serotonin transporter (SERT) receptor occupancy (RO) following single oral doses of LG-0317 tablets in healthy male participants; and to explore the pharmacokinetic/pharmacodynamic…
- Trial name
- NCT07708428
- Testing
- Cohort 1: LG-0317 20 mg, Cohort 1: LG-0317 40 mg, Cohort 1: LG-0317 80 mg
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- LinGang Laboratory
Lung Cancer
Low-dose Computed Tomography Screening for Lung Cancer in Relatives With Family History of Lung Cancer
Screening with the use of low-dose computed tomography (LDCT) reduces mortality from lung cancer. Relatives with family history of lung cancer are at increased risk of lung cancer compared to those without a family history in…
- Trial name
- NCT02519972
- Testing
- low dose computed tomography
- Volunteers
- 1,102 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Pulmonary Nodule, Clinical Decision Support
AI-Assisted Management of Pulmonary Nodules Found on Low-Dose CT in Health Screening
Pulmonary nodules are frequently found during low-dose computed tomography (LDCT) health screening. The main challenge is not only detecting nodules, but also recommending the appropriate next step, such as routine follow-up…
- Trial name
- AI-NoduleCare (NCT07841600)
- Testing
- AI-Assisted Pulmonary Nodule Reporting Workflow, Conventional Pulmonary Nodule Reporting Workflow
- Volunteers
- 2,000 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University