Clinical trials: CPAP Ventilation
Chronic Obstructive Pulmonary Disease
The Use of High Frequency Oscillations With NIV in Hypercapnic COPD Participants
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of chronic morbidity and mortality throughout the world, being the fourth leading cause of death in the world.
- Trial name
- NCT02680639
- Testing
- BiPAP Synchrony ventilator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Philips Respironics
Obstructive Sleep Apnea
TPAP for Comfort in OSA
TheraPAP is a prototype device (with full documented electrical and isolation safety) being developed by SleepRes for the treatment of obstructive sleep apnea (OSA) that can deliver either standard CPAP at a set pressure or what…
- Trial name
- NCT06264128
- Testing
- TPAP, CPAP
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- SleepRes Inc.
Sleep Apnea Syndromes
Effect of Self-Management on Improving Sleep Apnea Outcomes
Obstructive sleep apnea syndrome (OSA) is a common sleep disorder that is associated with serious medical and psychological complications.
- Trial name
- NCT00310310
- Testing
- Sleep Apnea Self-Management Program, Usual care
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Infant, Premature, Diseases, Respiratory Insufficiency Syndrome of Newborn
Impact of CPAP Level on V/Q Mismatch in Premature Infants
Continuous positive airway pressure (CPAP) is used in premature infants to maintain lungs open and facilitate gas exchange. When ventilation/perfusion (V/Q) mismatch is present, areas of the lung that are open for gas exchange do…
- Trial name
- NCT02983825
- Testing
- Continuous positive airway pressure (CPAP); level changes
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital of Philadelphia
Sleep Apnea Syndromes, Sleep Initiation and Maintenance Disorders
Understanding the Sleep Apnea/Insomnia Interaction
Nearly half of all patients with obstructive sleep apnea have insomnia symptoms, and in some, but not all cases, these insomnia symptoms are caused by the obstructive sleep apnea.
- Trial name
- NCT01824472
- Testing
- CPAP, CBT, CC
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Pennsylvania
Sleep Apnea Syndromes
Race And CPAP Effectiveness
Obstructive sleep apnea (OSA) is a major public health problem in the U.S. and more than 35% of Veterans are at high risk for OSA. OSA is associated with progression of hypertension, an important health problem in Veterans.
- Trial name
- RACE (NCT01960465)
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- VA Office of Research and Development
Sleep Apnea, Obstructive
Study to Predict the Need for Humidification Use and Comparison of the Effect of ThermoSmart™ and no Humidification on Adherence
Despite the effectiveness of continuous positive airway pressure (CPAP) in abolishing upper airway obstruction, acceptance of and adherence with therapy has been sub-optimal.
- Trial name
- NCT01517750
- Testing
- ICON Auto CPAP™ with Thermosmart heated tube, ICON Auto CPAP™ without Thermosmart heated tube
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Disordered Breathing
Continuous Positive Airway Pressure and Cardiometabolic Risk
The hypothesis for this study is that children with sleep disordered breathing will benefit from treatment with Continuous Positive Airway Pressure (CPAP) or Bi-level Positive Airway Pressure (BiPAP) in terms of reduction in…
- Trial name
- NCT01403194
- Testing
- CPAP/BiPAP
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mayo Clinic
Human Immunodeficiency Virus, Obstructive Sleep Apnea
Obstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living With HIV
The investigators seek to understand how the different underlying causes of OSA affect the way people living with HIV (PLWH) experience OSA.
- Trial name
- PLWH/OSA (NCT03575143)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea, Type 2 Diabetes
Effects of Continuous Positive Airway Pressure (CPAP) Treatment on Glucose Control in Patients With Type 2 Diabetes
The overall goal of the proposed protocol is to rigorously test the hypothesis that CPAP treatment has beneficial effects on glycemic control in patients with both type 2 diabetes (T2DM) and obstructive sleep apnea (OSA).
- Trial name
- CPAP (NCT01136785)
- Testing
- active CPAP Therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Chicago
Obstructive Sleep Apnea
Improving the Frequency and Quality of Sleep Apnea Care Management
OSA is a major chronic condition affecting the quality of life of millions of Americans. Per the Institute of Medicine new treatment adherence strategies are needed to help improve the quality of care, reduce social and economic…
- Trial name
- NCT01916655
- Testing
- Self-Management Care, Self-Management Mobile Care, Usual Care
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Sleep Apnea Syndromes, Oxidative Stress
Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea
Sleep-disordered breathing (SDB) is a condition in which a person experiences frequent breathing pauses during sleep, also known as sleep apnea.
- Conditions
- Sleep Apnea Syndromes, Oxidative Stress, Cardiovascular Diseases
- Trial name
- SASS (NCT00607893)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Obstructive Sleep Apnea
Obstructive Sleep Apnea in World Trade Center Responders
The goal of the study is to examine the possible underlying causes of sleep apnea (a disorder in which there are problems with breathing during sleep) in World Trade Center Responders.
- Trial name
- NCT01753999
- Testing
- Standard CPAP, CPAP - Flex
- Where
- 3 sites in United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
COVID-19, COVID
Early CPAP in COVID-19 Confirmed or Suspected Patients
There is surge in COVID infected patients in New York City with a shortage of hospital beds, ICU beds and ventilators. Strategies to reduce the need for all of the above are immediately needed.
- Conditions
- COVID-19, COVID, Coronavirus
- Trial name
- PAP-COVID (NCT04390191)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Apnea, Sleep, Chronic Fatigue Syndrome
Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
The purpose of this study is to determine any sleep disordered breathing in veterans with Gulf War Syndrome (GWS) and compare it to healthy normal asymptomatic Gulf War veterans.
- Trial name
- NCT00252629
- Testing
- Nasal CPAP treatment during sleep
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- US Department of Veterans Affairs
Sleep Apnea, Obstructive
Group-based Peer Support Versus Individual Education for Patients Undergoing CPAP Treatment
The investigators will compare two alternatives designed to maximize adherence to continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA) - peer-support administered in groups, versus individual…
- Trial name
- NCT02538419
- Testing
- CPAP + Peer Support, CPAP + Individual Education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea, Obstructive
Auto Continuous Positive Airway Pressure (CPAP) Based Energy Spectrum Analysis of Flow for Treatment of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)
Nasal Continuous Positive Airway Pressure (CPAP) is the standard therapy for obstructive sleep apnea hypopnea syndrome (OSAHS). This is most commonly administered as a single positive pressure that has been individualized for the…
- Trial name
- NCT00750165
- Testing
- SleepStyle 200 Auto Series CPAP Humidifier
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Fisher and Paykel Healthcare
Epilepsy, Sleep Apnea
Effects of Treating Obstructive Sleep Apnea in Epilepsy
The purpose of this trial is to work out design issues prior to conducting a definitive phase 3 trial to determine whether treating sleep-related breathing disorders in people with epilepsy results in improvement in seizure…
- Conditions
- Epilepsy, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- NCT00047463
- Testing
- continuous positive airway pressure (CPAP)
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Vanderbilt University
Sleep Apnea, Sleep Disordered Breathing
Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea
Patients with Obstructive Sleep Apnea Syndrome (OSAS) will evidence higher levels of salivary cortisol and alpha-amylase levels prior to use of placebo and continuous positive airway pressure (CPAP) and will evidence a decrease…
- Trial name
- NCT01196117
- Testing
- 14 days of CPAP therapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medical College of Wisconsin
Obstructive Sleep Apnea
Effects of CPAP on Visceral Fat Thickness
We hypothesize that patients with untreated OSAS will have more visceral fat, fatty liver and increased carotid artery thickness whereas treatment with CPAP may reduce the mesenteric and liver fat, plasma lipids, carotid artery…
- Trial name
- NCT01828281
- Testing
- CPAP
- Where
- China
- Volunteers
- 141 people
- Sponsor
- Chinese University of Hong Kong