Clinical trials: CPAP Ventilation
Sleep Disordered Breathing, Sleep Apnea
Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac rhythm disturbance in adults, with prevalence expected to rise significantly the coming decades.
- Conditions
- Sleep Disordered Breathing, Sleep Apnea, Paroxysmal Atrial Fibrillation
- Trial name
- NCT02727192
- Testing
- PAP (CPAP or ASV)
- Where
- Norway
- Volunteers
- 109 people
- Sponsor
- Oslo University Hospital
Obstructive Sleep Apnea
Impact of Telemonitoring to Improve Adherence in Continuous Positive Airway Pressure (CPAP)-Treated Patients
Improvement in CPAP adherence can be obtained by usingTelemonitoring. T4P® is a telemonitoring unit added on CPAP device allowing to obtain a daily report of usage duration, mask leaks, pressure and apnea-hypopnea index.
- Trial name
- NCT02773953
- Testing
- T4PTelemonitoring, CPAP
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Bronchopulmonary Dysplasia
Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator
Very premature infants often cannot breathe on their own and require assistance with a respirator. Conventional respirators deliver air or oxygen via a breathing tube placed through the mouth to the airway (endotracheal tube).
- Trial name
- NCT01440647
- Testing
- Extubation to NIPPV, Extubation to CPAP
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Obstructive Sleep Apnea
The Effect of Mandibular Advancement Devices on Markers of Cardiovascular Health in Obstructive Sleep Apnea Patients
Obstructive sleep apnea (OSA) is a type of disordered breathing defined by the repetitive obstruction of airflow during sleep due to upper airway collapse. Each obstructive event contributes to decreased blood oxygen, or hypoxia.
- Trial name
- NCT05387122
- Testing
- mandibular advancement device (MAD)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Obstructive Sleep Apnea
PAP Therapy Sleep Apnea and Exercise
Positive airway pressure (PAP) therapy is generally offered to patients with obstructive sleep apnea. The investigators suggest that beneficial effects of PAP therapy is by preventing apneas and therefore reducing cardiac and…
- Trial name
- NCT01786291
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- University of Gaziantep
Surfactant Deficiency Syndrome Neonatal
deMISTify: The Impact of Ventilator Pressure Levels During Minimally Invasive Surfactant Therapy on Lung Aeration in Preterm Infants
Infants born preterm (before 36 weeks' gestation age) have immature lungs and struggle to breathe on their own. They are supported via respiratory machines like ventilators, as well as pharmaceutical aids like surfactant…
- Trial name
- deMISTify (NCT07522346)
- Testing
- Lung Recruitment Manoeuvre prior to Minimally Invasive Surfactant Therapy, Control (Minimally Invasive Surfactant Therapy)
- Where
- Australia
- Volunteers
- 36 people
- Sponsor
- Murdoch Childrens Research Institute
Obstructive Sleep Apnea (OSA), Ischemic Optic Neuropathy/Optic Nerve Stroke
Optic Nerve Injury in Obstructive Sleep Apnea Patients
Ischemic optic neuropathy (ION) is damage to the optic nerve caused by ischemia and hypoxia of the optic nerve due to an impairment of the blood supply to the optic nerve from the arteries.
- Trial name
- NCT06748703
- Testing
- CPAP Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing Medical University
Obstructive Sleep Apnea of Adult, Heart Valve Diseases
Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement
Sleep apnea including obstructive sleep apnea (OSA) and central sleep apnea (CSA), are common in patients with cardiovascular disease.
- Trial name
- NCT03839654
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing Medical University
Intubation Complication, PreTerm Birth
NIPPV Versus Bi-level Nasal Continuous Positive Airway Pressure Following Extubation
Mechanical ventilation is important in the care of preterm infants with respiratory failure, but may be associated with lung injury. Efforts are needed to avoid or minimize the use of mechanical ventilation.
- Trial name
- NCT02842190
- Testing
- NIPPV
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Drowning
Drowning-related Acute Respiratory Failure
The purpose of this study is to assess the Non-Invasive Ventilation-Continuous Positive Airway Pressure efficacy (experimental group) for drowning related Acute Respiratory Failure compared to Oxygen Supply by face mask…
- Trial name
- CPAPDROWNING (NCT06183827)
- Testing
- Emergency Medical Service intervention : Oxygen Supply strategy, Emergency Medical Service intervention : Continuous Positive Airway Pressure strategy
- Where
- 9 sites in France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Obstructive Sleep Apnea
Upper Airway Stimulation Versus Continuous Positive Airway Pressure
Standard therapy in patients with obstructive sleep apnea (OSA) is continuous positive airway pressure (CPAP). 30% to 50% are not adherent to this therapy and need an alternative treatment.
- Trial name
- NCT03756805
- Testing
- upper airway stimulation, continuous positive airway pressure
- Where
- Germany
- Volunteers
- 227 people
- Sponsor
- Technical University of Munich
Infant, Premature, Diseases, Bronchopulmonary Dysplasia
A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams
The purpose of this study is to compare two methods of delivering Nasal Continuous Airway Pressure (NCPAP): Biphasic Mode and a continuous mode, to see which is better in getting babies off the ventilator and decreasing lung…
- Conditions
- Infant, Premature, Diseases, Bronchopulmonary Dysplasia, Apnea of Prematurity
- Trial name
- NCT00308789
- Testing
- Biphasic Infant flow NCPAP, CPAP
- Where
- Canada
- Volunteers
- 136 people
- Sponsor
- Mount Sinai Hospital, Canada
Apnea, Sleep Apnea Syndromes
Comparison of Two Telemonitoring Auto-titrating Modalities in OSA Patients
This study compares the titration pressures achieved through two auto-titrating modalities, a new incremental fixed pressure mode versus routine auto-adjusting pressure mode, in CPAP-naïve obstructive sleep apnea patients.
- Conditions
- Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Sleep Disordered Breathing
- Trial name
- NCT03734341
- Testing
- EZ START Titration, APAP Titration
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Basque Health Service
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome
Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA.
- Trial name
- NCT01033266
- Testing
- CPET
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Oklahoma
Neonatal Respiratory Distress Related Conditions, Meconium
Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Meconium Exposure
Meconium in the amniotic fluid occurs in about one out of seven pregnancies and increases the chance that a newborn may have breathing problems after birth.
- Conditions
- Neonatal Respiratory Distress Related Conditions, Meconium, Perinatal Morbidity, Neonatal Acidosis
- Trial name
- PEARL (NCT07274527)
- Testing
- Intrauterine pressure catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Medical College of Wisconsin
Obstructive Sleep Apnea
First Line Obstructive Sleep Apnea Treatment Study
The main objective is to evaluate the overall effectiveness of MAD therapy as a first line treatment, including both efficacy in terms of reduction in OSA severity as well as objective compliance, in patients recently diagnosed…
- Trial name
- FLOSAT (NCT05393531)
- Testing
- Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP)
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Peer-Driven Intervention for Sleep Apnea
Fragmentation of care can lead to poor treatment adherence in patients with chronic medical conditions which can, in turn, lead to adverse health consequences, poor quality of life, and patient dissatisfaction.
- Trial name
- PCORI (NCT02056002)
- Testing
- Usual Care, Peer-Buddy System
- Where
- United States
- Volunteers
- 362 people
- Sponsor
- University of Arizona
Obstructive Sleep Apnea (OSA), Atrial Fibrillation (Paroxysmal)
CPAP Therapy and Atrial Fibrillation Recurrence in OSA
Obstructive sleep apnea (OSA) is a major modifiable risk factor for atrial fibrillation (AF). Continuous positive airway pressure (CPAP) therapy has been shown to improve cardiovascular outcomes; however, real-world data on its…
- Trial name
- CPAP-AF (NCT07358429)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Bulgaria
- Volunteers
- 91 people
- Sponsor
- Medical University of Sofia
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Obstructive Sleep Apnea Syndrome
Phonoaudiologic Therapy Adjunct to Treatment on Patients With Obstructive Sleep Apnea
Objective: to evaluate the effects of a speech therapy exercises program in the treatment of Obstructive Sleep Apna Syndrome (OSAS) patients based on the clinical and polysomnography (PSG) parameters.
- Trial name
- NCT01289405
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa