Clinical trials: COPD Exacerbations
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Efficacy and Safety of Fluticasone Furoate (FF)/GW642444 Inhalation Powder in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The Purpose of this study is to assess the efficacy and safety of three strengths of the FF/GW642444 Inhalation Powder in subject with Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT01009463
- Testing
- FF/GW642444 Inhalation Powder, GW642444 Inhalation Powder
- Where
- 188 sites in United States, Argentina and 13 more
- Volunteers
- 1,626 people
- Sponsor
- GlaxoSmithKline
COPD Exacerbation
Mitoquines in COPD
The most important pathogenic factor of Chronic Obstructive Pulmonary Disease (COPD) in the Western world is chronic exposure to tobacco smoke, which induces oxidative stress not only in the respiratory system, but in all the…
- Trial name
- NCT04449419
- Testing
- There is not intervention.
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Hospital Universitario Marqués de Valdecilla
Remote Patient Monitoring in COPD Patients
Compare the Effect of a Remote Monitoring System Using the EXACT Tool to Reduce Hospitalizations Due to Chronic Obstructive Pulmonary Disease (COPD) Exacerbations. EXACT = Exacerbations of Chronic Pulmonary Disease Tool.
The purpose of this pilot study is to evaluate a remote patient monitoring (RPM) system using a daily PRO tool (EXACT = Exacerbations of Chronic Pulmonary Disease Tool), in preventing hospitalization from Chronic Obstructive…
- Trial name
- PREMIERE (NCT01744028)
- Testing
- Remote Patient Monitoring, Usual care
- Where
- 20 sites in Spain, Sweden
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Pulmonary Disease, Chronic Obstructive
Investigation of Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy of Oral Danirixin in Symptomatic COPD Subjects With Mild to Moderate Airflow Limitation at Risk for Exacerbations
The aim of this First Time in Patient study is to obtain initial information on the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of repeat daily administration of danirixin in subjects with…
- Trial name
- NCT02130193
- Testing
- Danirixin
- Where
- 16 sites in United States, Germany
- Volunteers
- 102 people
- Sponsor
- GlaxoSmithKline
Copd, COPD Exacerbation
Atorvastatin Effect on Reduction of COPD Exacerbations
It is a randomized, multicenter, prospective, double-blind, placebo controlled, interventional clinical trial that will be conducted in Poland, in about 12 Hospital Pulmonary Departments to evaluate the effectiveness of…
- Conditions
- Copd, COPD Exacerbation, Smoking, Gene Expression
- Trial name
- Captain (NCT04789057)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Poland
- Volunteers
- 460 people
- Sponsor
- Medical University of Bialystok
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Testing a Prediction Algorithm Into a Running Telehealth System for Patients With COPD
This trial will test a COPD prediction algorithm into a telehealth system from the previous Danish large-scale trial, TeleCare North (NCT01984840).
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, COPD Exacerbation Acute, COPD
- Trial name
- NCT05218525
- Testing
- Algorithm
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Aalborg University
Chronic Obstructive Pulmonary Disease
Azithromycin for Acute Exacerbations Requiring Hospitalization
This project (funded by the IWT-TBM program) will organize a randomized placebo-controlled multicenter intervention trial in 500 COPD patients to study the effectiveness and safety of azithromycin therapy in the acute setting of…
- Trial name
- BACE (NCT02135354)
- Testing
- Azithromycin
- Where
- 20 sites in Belgium
- Volunteers
- 301 people
- Sponsor
- Wim Janssens
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe…
- Trial name
- OBERON (NCT05166889)
- Testing
- Tozorakimab
- Where
- 212 sites in United States, Argentina and 19 more
- Volunteers
- 1,132 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections
Viral Infections in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
The objectives of the study are to determine the prevalence of respiratory virus infections in COPD patients, during and outside acute exacerbation to explore the impact of these viral infections on the outcome of these patients…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Infections, Virus Diseases, Lung Diseases, Obstructive
- Trial name
- VICE (NCT00448604)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University Hospital, Geneva
Respiratory Synctial Virus, COPD
Respiratory Syncytial Virus Infection In Exacerbations of Chronic Obstructive Pulmonary Diasease: The RECODE Study
The goal of this observational study is to determine the prevalence of respiratory syncytial virus (RSV) infection and evaluate its association with clinical outcomes in patients with chronic obstructive pulmonary disease (COPD)…
- Conditions
- Respiratory Synctial Virus, COPD, Chronic Obstructive Pulmonary Disease (COPD), Exacerbation of COPD
- Trial name
- RECODE (NCT06735612)
- Where
- Spain
- Volunteers
- 716 people
- Sponsor
- Fundacio Privada Mon Clinic Barcelona
Chronic Obstructive Pulmonary Disease
Infectious Etiology of Acute Exacerbations of COPD
To assess the infectious etiology related to acute exacerbation of COPD in Hong Kong
- Trial name
- NCT00441389
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
COPD Exacerbation
COPD Aerosol Study Comparing the Efficacy of Nebulizers Versus Dry Powder Inhalers
The purpose of this study is to compare drug delivery and lung function after treatment with formoterol from a nebulizer versus a dry powder inhaler (DPI) in patients recovering from severe exacerbations of COPD.
- Trial name
- NCT02291016
- Testing
- Formoterol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Pulmonary Disease, Chronic Obstructive
Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This is a multicenter, prospective, randomized, double-blind, placebo-controlled trial that will enroll 1028 patients with at least moderately severe COPD over a three year period and follow them at regular intervals for one…
- Trial name
- NCT02587351
- Testing
- Metoprolol succinate
- Where
- 27 sites in United States
- Volunteers
- 532 people
- Sponsor
- University of Minnesota
COPD, Acute Exacerbation of COPD
Evaluating Customized Antibiotic Duration (CDA) Strategy in Acute Exacerbations of COPD
The goal of this clinical trial is to learn whether a shorter course of antibiotics (7 days) works as well as the usual longer course (14 days) for adults admitted to hospital with a flare-up of chronic obstructive pulmonary…
- Trial name
- CDA (NCT07708337)
- Testing
- 7-day antibiotic course, 14-day antibiotic course
- Where
- Pakistan
- Volunteers
- 560 people
- Sponsor
- Capital Development Authority (CDA)
COPD, Chronic Obstructive Pulmonary Disease
Strategy for Early Treatment of Exacerbations in COPD: Standing Prescriptions of Advair With a Written Action Plan in the Event of an Exacerbation
The purpose of this pilot study is to determine whether early treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with a combination therapy, Salmeterol + Fluticasone Propionate (SFP - Advair) will…
- Trial name
- NCT02136875
- Testing
- Double dose of Salmeterol + Fluticasone Propionate, Self-management education on the use of a self-administered prescription for exacerbation., Self-administered prescription
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD
This study group forms the normal subject control group in an experiment designed to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD) show abnormal responsiveness to…
- Trial name
- NCT00281203
- Testing
- blood drawing, fiberoptic bronchoscopy
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan