Clinical trials: COPD, open to volunteers
Oxygen Toxicity, COPD Bronchitis
Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates
Oxygen therapy is at the heart of the healthcare system. Oxygen flow rates depend on a number of confounding factors confounding factors (target used, skin pigmentation, pulse oximeter used, etc.) The investigators have recently…
- Conditions
- Oxygen Toxicity, COPD Bronchitis, Respiratory Failure
- Trial name
- Interfaces (NCT06646991)
- Testing
- Nasal canula - up to 6 liters per minute, Nasal canula - up to 15 liters per minute, Open oxygen mask
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
COPD, Chronic Obstructive Pulmonary Disease
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
The dNerva Lung Denervation System is one-time treatment intended to improve breathing in Chronic Obstructive Pulmonary Disease (COPD) patients on standard medical care.
- Trial name
- AIRFLOW-4 (NCT07051707)
- Testing
- Targeted Lung Denervation (TLD)
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Nuvaira, Inc.
Chronic Obstructive Pulmonary Disease (COPD), With Poitive H Pylori
Impact of Eradication Therapy on Helicobacter Pylori Infection With Chronic Obstructive Pulmonary Disease:
Helicobacter pylori (HP) is a well-established pathogen responsible for chronic gastritis and peptic ulcer disease. Its presence has been implicated in the development of gastric malignancies such as adenocarcinoma and…
- Trial name
- NCT07574879
- Testing
- Eradication of Helcobacter Pylori
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Zagazig University
Asthma, COPD (Chronic Obstructive Pulmonary Disease)
Reducing Exposure With Air Cleaners and Technology
Fine particulate matter (PM2.5) is a type of air pollution made up of extremely tiny particles that can harm our health. Because PM2.5 particles are so small, they can travel deep into the lungs when inhaled.
- Trial name
- REACT (NCT07914010)
- Testing
- Air Cleaner, PM2.5 Monitor with Visual Air Quality Indicator, Educational Materials
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of California, Berkeley
COPD - Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation
Comprehensive Maintenance Program: a Health Haven for COPD in Lleida.The NAPOLEON Project.
Introduction: Pulmonary rehabilitation programs (PRPs) are known to reduce symptoms such as dyspnea and fatigue, while improving functional capacity and quality of life in individuals with chronic obstructive pulmonary disease…
- Conditions
- COPD - Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation, Randomised Controlled Trial
- Trial name
- NAPOLEON (NCT07394712)
- Testing
- Interdisciplinary intervention
- Where
- 2 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Asthma Acute, COPD Exacerbation Acute
Rademikibart IV for Acute Asthma and COPD Exacerbation
A Phase 2, open-label, single-arm trial to evaluate IV rademikibart as an add-on treatment for acute exacerbation in participants with asthma or COPD with type 2 inflammation
- Trial name
- NCT07705737
- Testing
- Rademikibart
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Connect Biopharm LLC
Chronic Obstructive Pulmonary Disease (COPD)
Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations
The purpose of this study is to investigate the safety and tolerability of Metformin and how it changes blood markers associated with aging in persons who have chronic obstructive pulmonary disease (COPD) who do not have diabetes.
- Trial name
- INSPIRE-COPD-E (NCT07275359)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Swiss Chronic Obstructive Pulmonary Disease (COPD) Management Cohort
1. Background Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory disease of the lungs, which is most commonly caused by smoking.
- Trial name
- NCT02065921
- Where
- Switzerland
- Volunteers
- 265 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Chronic Obstructive Pulmonary Disease (COPD)
cfMSC Stem Cell Therapy Targeting COPD
The primary objectives are to evaluate the safety and efficacy of infusion of fully characterized clonally derived fetal mesenchymal stem cells (cfMSCs) for the control of severe symptoms associated with moderate to severe…
- Trial name
- NCT07477600
- Testing
- clonal fetal MSCs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Chronic Obstructive Pulmonary Disease (COPD), Respiratory Muscle Dysfunction
Multimodal Assessment of NMES Effects on Respiratory and Peripheral Muscles in COPD
The goal of this clinical trial is to learn if targeted neuromuscular electrical stimulation (NMES) can treat respiratory and peripheral muscle weakness in patients with chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Respiratory Muscle Dysfunction, Muscle Weakness
- Trial name
- NMES in COPD (NCT07910006)
- Testing
- Neuromuscular Electric Stimulation, Exercise
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Universitas Padjadjaran
Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis)
Construction and Validation of an Impulse Oscillometry (IOS)-Based Platform for Screening, Diagnosis, and Management of Chronic Airway Diseases
This is a multicenter, observational study aiming to construct and validate an Impulse Oscillometry (IOS)-based platform for the screening, diagnosis, and management of chronic airway diseases (COPD and asthma).
- Trial name
- NCT07910409
- Where
- China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Pulmonary Disease, Chronic Obstructive (COPD), Hypercapnia
Effectiveness and Efficiency of Home Telemonitoring and Non-invasive Ventilation in Patients With COPD and Hypercapnia (EVALECO)
The purpose of this study is to evaluate the effectiveness and clinical efficiency of combining home non-invasive ventilation (NIV) with a continuous remote telemonitoring (TM) system in patients with Chronic Obstructive…
- Trial name
- EVALECO (NCT07679646)
- Testing
- Home Non-Invasive Ventilation and Telemonitoring
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Air Liquide Healthcare Spain
Chronic Obstructive Pulmonary Disease (COPD)
To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment
This is a Phase 2 study of the efficacy, safety, tolerability and pharmacokinetics of two doses of EXPD-101 in participants with COPD.
- Trial name
- Navigator (NCT07684820)
- Testing
- EXPD-101/FXS7553 Dose 1, EXPD-101/FXS7553 Dose 2
- Where
- 35 sites in United States, Canada and 2 more
- Volunteers
- 600 people
- Sponsor
- Expedition Therapeutics, Inc
Chronic Obstructive Pulmonary Disease (COPD)
PRA-216 COPD Safety and Biomarker Study
This study will evaluate the safety, tolerability, pharmacokinetics and immunogenicity of PRA-216 compared to placebo in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07730281
- Testing
- PRA-216
- Where
- 5 sites in Australia
- Volunteers
- 40 people
- Sponsor
- Prana Therapies Inc
COPD, Chronic Obstructive Pulmonary Disease (COPD)
Phase 2b Efficacy and Safety Study of AERO-007, an Inhaled LABA+LAMA Combination for Nebulization Delivery in COPD Patients
This is a phase 2b, randomized, double-blind, placebo-controlled, dose-ranging,14-day dosing, 2-period crossover study in participants with chronic obstructive pulmonary disease (COPD).
- Conditions
- COPD, Chronic Obstructive Pulmonary Disease (COPD), Lung Disease Chronic, Lung Diseases, Obstructive
- Trial name
- AERODUO-2 (NCT07896252)
- Testing
- AERO-001, AERO-002, AERO-007
- Where
- 2 sites in United Kingdom
- Volunteers
- 64 people
- Sponsor
- AeroRx Therapeutics Inc.
COPD With Coronary Artery Calcificatio
A TwiCs Study of TCM Management Based on Cardiopulmonary Screening in COPD
This clinical study seeks to understand whether, for people with stable COPD and coronary artery calcification found on chest CT, adding traditional Chinese medicine (TCM) health guidance (including dietary guidance) based on CT…
- Trial name
- NCT07900763
- Testing
- TCM-Based Health Management Guided by Coronary Artery Calcium Scores
- Volunteers
- 200 people
- Sponsor
- Henan University of Traditional Chinese Medicine
COPD (Chronic Obstructive Pulmonary Disease)
Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD
Chronic obstructive pulmonary disease (COPD), one of the leading causes of death in the US, disproportionately affects low socioeconomic communities.
- Trial name
- RISE (NCT05572632)
- Testing
- COPD Wellness, COPD Wellness Plus+, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 387 people
- Sponsor
- University of California, San Francisco
COPD Exacerbation, ICU
Characteristics and Outcomes of Patients Admitted to ICU for a Severe Acute Exacerbation of COPD.
The objective of this prospective observational study is to describe the epidemiological, clinical and biological characteristics of patients admitted in ICU for a severe acute exacerbation of COPD, and to assess the different…
- Trial name
- COPDregister (NCT06257329)
- Testing
- register
- Where
- 4 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Alexis FERRE
Alpha 1-Antitrypsin, COPD
Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
The goal of this study is to learn whether patients who have a genetic mutation in the genes that cause alpha 1 antitrypsin deficiency also have genetic variation in nearby genes that can increase risk for reduced immune function…
- Conditions
- Alpha 1-Antitrypsin, COPD, Antibody Deficiency
- Trial name
- IgG in AATD (NCT07135427)
- Testing
- 20-valent pneumococcal conjugate vaccine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
COPD (Chronic Obstructive Pulmonary Disease), Airway Disease
Comparing Advanced Technologies to Standard Testing for the Diagnosis of Airway Disease in Hospital and Community Settings
Airway disease, such as chronic obstructive pulmonary disease (COPD), is usually diagnosed through breathing tests like spirometry.
- Trial name
- BREATHE (NCT07798596)
- Testing
- Capnography, Oscillometry, FENO
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust