Clinical trials: CLBP - Chronic Low Back Pain
Chronic Low-back Pain, Degenerative Disc Disease
Postmarket Clinical Follow-Up Study on Arcadius XP L® Interbody Fusion Device
The purpose of this study is to collect clinical and radiological mid-term (min. 1 year) data on the ArcadiusXP L® lumbar stand-alone cage in a post-market clinical follow-up study (PMCF) limited to 60 patients.
- Conditions
- Chronic Low-back Pain, Degenerative Disc Disease, Spondylolysis Lumbar, Postdiscectomy Syndrome
- Trial name
- ARREST (NCT05944081)
- Testing
- ArcadiusXP L® Interbody Fusion System
- Where
- 3 sites in Germany
- Sponsor
- Aesculap AG
Chronic Pain, Low Back Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking either WHO Step…
- Trial name
- NCT00983385
- Testing
- Tapentadol PR, Observation period
- Where
- 46 sites in Austria, Croatia and 7 more
- Volunteers
- 208 people
- Sponsor
- Grünenthal GmbH
Pain, Low Back Pain
Efficacy and Safety Study of Buprenorphine HCl Buccal Film in Subjects With Low Back Pain
The purpose of this study is to determine whether buprenorphine hydrochloride (HCl) buccal film is effective and safe in the treatment of chronic low back pain (CLBP).
- Trial name
- NCT01256450
- Testing
- Buprenorphine
- Where
- 24 sites in United States
- Volunteers
- 334 people
- Sponsor
- BioDelivery Sciences International
Chronic Low Back Pain
Enso Pilot Study for Chronic Low Back Pain
Enso is a portable device for the treatment of chronic and acute types of musculoskeletal pain. This study is being designed as a single blind, sham-controlled randomized clinical trial.
- Trial name
- NCT03409783
- Testing
- ENSO Device
- Where
- 2 sites in United States
- Sponsor
- Thimble Bioelectronics, Inc.
Chronic Low Back Pain
Pulsed Shortwave Therapy Treatment for Chronic Musculoskeletal Low Back Pain
The ActiPatch is a cutaneous device which is CE marked approved for relief of pain and has FDA clearance as an over the counter device for the adjunctive treatment of osteoarthritis of the knee and plantar fasciitis.
- Trial name
- PSWT (NCT03240146)
- Testing
- Pulsed Shortwave Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- BioElectronics Corporation
Chronic Low Back Pain
Pulsed Shortwave Therapy (ActiPatch®) Study in Chronic Low Back Pain
This study aims to test the efficacy of the ActiPatch® device by means of a randomized double blind controlled trial in a convenience sample of chronic low back pain patients at RPAH pain clinic.
- Trial name
- PSWT (NCT03828864)
- Testing
- Pulsed Shortwave Therapy
- Volunteers
- 142 people
- Sponsor
- BioElectronics Corporation
Low Back Pain
Efficacy and Safety of ARTRA (Glucosamine Plus Chondroitin Sulfate Combination) in Treatment of Chronic Low Back Pain
To study the safety and efficacy of ARTRA (glucosamine chondroitin sulfate) in the treatment of non-specific low-back pain of lumbosacral localization in ambulatory care.
- Trial name
- NCT01990729
- Testing
- ARTRA
- Where
- Russia
- Volunteers
- 10,000 people
- Sponsor
- Unipharm, Inc.
Low Back Pain
RN624 In Adult Patients With Chronic Low Back Pain
The primary objective of this study is to evaluate the analgesic efficacy of RN624 compared with placebo and compared with naproxen in the treatment of adult patients with chronic low back pain.
- Trial name
- NCT00584870
- Testing
- Naproxen, PF-04383119 (RN624)
- Where
- 38 sites in United States
- Volunteers
- 220 people
- Sponsor
- Pfizer
Degenerative Disc Disease
Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain
The primary purpose of this study is to evaluate the efficacy of rexlemestrocel-L+HA compared to control in reducing low back pain at 12 months post-treatment and safety of a single injection of rexlemestrocel-L+HA injected into…
- Trial name
- HyaluronicAcid (NCT06325566)
- Testing
- Rexlemestrocel-L + HA mixture, Saline
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- Mesoblast, Ltd.
Pain, Chronic Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking WHO Step III…
- Conditions
- Pain, Chronic Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT00986258
- Testing
- Tapentadol Prolonged Release
- Where
- 27 sites in Belgium, Czechia and 6 more
- Volunteers
- 136 people
- Sponsor
- Grünenthal GmbH
Low Back Pain, Recurrent
Evaluation of Performances and Safety of the Medical Device Blueback® Physio for Patients With Chronic Low Back Pain
The main objective of this clinical investigation is to show the superiority of a rehabilitation based on the use of Blueback® Physio compared to a rehabilitation without the use of Blueback® Physio in terms of reducing the time…
- Trial name
- ABC-TRACC (NCT04592094)
- Testing
- Blueback® Physio
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Blueback
Chronic Low Back Pain
Intraosseous Basivertebral Nerve Ablation for Treatment of Chronic Low Back Pain
Objective of study is to evaluate the procedural success rate, clinical effectiveness, and heath-economic profile using the Intercept Intraosseous Nerve Ablation System in adult subjects with chronic low back pain in the…
- Trial name
- CLBP (NCT03658018)
- Testing
- Intracept System Ablation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Relievant Medsystems, Inc.
Osteoarthritis, Back Pain
A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis
The purpose of this study is to compare oxycodone/naloxone combination tablet and codeine/paracetamol tablets in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis.
- Trial name
- NCT00784810
- Testing
- Oxycodone/Naloxone, Codeine/Paracetamol
- Where
- United Kingdom
- Volunteers
- 247 people
- Sponsor
- Napp Pharmaceuticals Limited
Chronic Low Back Pain
Digital Therapeutics (DTx) for Pain: Pilot Study of a Virtual Reality Software for Chronic Pain
Prospective, randomised, double-blind, 3-arm parallel group comparison of 2 different virtual reality softwares and standard care.
- Trial name
- VIRPI (NCT04225884)
- Testing
- DTx for pain software, Control software, Standard care
- Where
- Finland
- Volunteers
- 34 people
- Sponsor
- Orion Corporation, Orion Pharma
Chronic Pain
Efficacy and Safety of Oxymorphone Extended Release in Opioid-Experienced Patients With Chronic Non-Malignant Pain
The purpose of this study is to evaluate the analgesic efficacy and safety of oxymorphone extended release in opioid-experienced patients with chronic low back pain.
- Trial name
- NCT00226421
- Testing
- Oxymorphone Extended Release
- Where
- 31 sites in United States
- Volunteers
- 120 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Chronic Low Back Pain
Restoration of Disc Height Reduces Chronic Low Back Pain
The investigators hypothesize that a 6-week treatment of non-invasive spinal decompression reduces discogenic low back pain (LBP), increases lumbar disk height, and that an increase in lumbar disc height is associated with…
- Trial name
- NCT00828880
- Testing
- DRX9000
- Where
- United States
- Sponsor
- NEMA Research, Inc.
Non-specific Chronic Low Back Pain
Evaluating the Efficacy and Safety of Octane Aether for Treating Chronic Low Back Pain
The goal of this clinical trial is to evaluate the safety of the Octane Aether device and to determine whether the device is effective in treating symptoms of non-specific chronic low back pain in adults.
- Trial name
- NCT07614568
- Testing
- Pulsed electromagnetic field stimulator
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Octane Innovation Inc.
Low Back Pain, Low Back Sprain
Usability of a Multimodal External Neuromodulatory Device to Relieve Acute Low Back Pain
Ten patients with acute or chronic low back pain will be invited to try a multimodal device for 20 minutes. Pain will be recorded prior to and after use, and feedback on the device will be elicited.
- Conditions
- Low Back Pain, Low Back Sprain, Low Back Pain, Recurrent
- Trial name
- NCT04494841
- Testing
- Duotherm VibraCool Back Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MMJ Labs LLC
Osteoarthritis, Rheumatoid Arthritis
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501, a fixed-dose combination oral tablet of 800 mg ibuprofen and 26.6 mg famotidine for patients that require long-term NSAID treatment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- NCT00984815
- Testing
- HZT-501
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Osteoarthritis, Knee, Diabetic Neuropathic Pain
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs).
- Conditions
- Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
- Trial name
- CPMP (NCT05986292)
- Testing
- LY3016859 ISA, LY3556050 ISA, LY3526318 ISA
- Where
- 64 sites in United States, Puerto Rico
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company