Clinical trials: CHIP
Genetics, Population
Population Genomic Diversity of France
Having access to DNA sequences from individuals that share common ancestry with patients is of interest when analysing individual genomes for diagnoses.
- Trial name
- POPGEN (NCT04183023)
- Testing
- Collection of a salivary sample
- Where
- France
- Volunteers
- 10,250 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
DNMT3A Gene Mutation
Metformin Inhibits DNMT3A Clonal Hematopoiesis in Acute Leukemia
This is a prospective, single-arm clinical study evaluating the efficacy and safety of metformin in inhibiting DNMT3A R882-driven clonal hematopoiesis (CH) in patients with acute leukemia (AL) who are in remission and under…
- Trial name
- NCT07188740
- Testing
- Metformin
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Coronary Artery Disease
Prasugrel 5 mg vs. Ticagrelor 60 mg in CHIP (E5TION)
E5TION will evaluate the efficacy, safety and tolerability of tailored two regimens (prasugrel 5mg/d vs. ticagrelor 60mg bid) in high-risk patients undergoing PCI (CHIP: COmplex and Higher-Risk Indicated PCI/PatieNts).
- Trial name
- E-5TION (NCT04734353)
- Testing
- Prasugrel 5mg, Ticagrelor 60mg
- Where
- 8 sites in South Korea
- Volunteers
- 492 people
- Sponsor
- Gyeongsang National University Hospital
Clonal Hematopoiesis
Donor CHIP and Allogeneic HSCT Outcome
Current data on the impact of donor CHIP on long-term recipient outcome remain largely speculative. Data on the impact of donor CHIP including on allograft function, immunologic dysfunction, graft versus host disease (GVHD)…
- Trial name
- NCT04689750
- Testing
- Next generation sequencing
- Where
- Hong Kong
- Volunteers
- 850 people
- Sponsor
- The University of Hong Kong
First Cadaveric Renal Graft
Evaluation of an Early Screening Test of Chronic Rejection and of Operational Tolerance by MicroArray in Renal Graft (Protocol DPRC Array)
The aim of the study is to explore the possibility to identify, at an early stage after a renal graft and from blood samples collected within first months after graft, a predictive transcriptional profile of long term occurence…
- Trial name
- NCT00746057
- Testing
- DNA chip
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Nantes University Hospital
Cancer of Pancreas
Cell-Free DNA Chromatin Immunoprecipitation (ChIP) for Diagnosing Cancer
The goal of this research is to use chromatin immunoprecipitation, a method used to study protein-DNA interaction, as a tool to diagnose and prognose pancreatic ductal adenocarcinoma in human samples.
- Trial name
- NCT06148298
- Testing
- Non-Human Subject Research study.
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Central Florida
HIV
Multiplex Microarray Chip-Based Diagnosis of Respiratory Infections
Respiratory infections have a high associated morbidity and mortality, especially in immunocompromised patients. To initiate effective treatment of respiratory infections, it is essential that a rapid and thorough laboratory…
- Trial name
- NCT01212042
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Colorectal Cancer, Primary Peritoneal Cavity Cancer
Systemic Chemotherapy With or Without Intraperitoneal Chemohyperthermia in Treating Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as leucovorin, fluorouracil, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00769405
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- 20 sites in France
- Volunteers
- 264 people
- Sponsor
- UNICANCER
Rhinitis, Allergic
The Oligonucleotide Chip Analysis for Allergic Rhinitis Treatment in Herbal Plaster and Acupuncture
Using Oligonucleotide Chip Analysis, investigators compared gene expression levels in allergic rhinitis patients before and after a series of acupoint herbal plaster and Acupuncture treatment.
- Trial name
- NCT02486159
- Testing
- Herbal plaster (Sanfujiu), Acupuncture
- Volunteers
- 50 people
- Sponsor
- Chang Gung Memorial Hospital
Cardiovascular Diseases, Diabetes Mellitus
Complete Health Improvement Program (CHIP) Risk Reduction/Claims Evaluation Project
The project proposes to provide the Complete Health Improvement Program (CHIP) initially up to 25 adult (non-pregnant) Ohio University employees (and/ or their adult family members) with with diabetes / prediabetes, obesity /…
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Hypertension, Dyslipidemias
- Trial name
- NCT02977884
- Testing
- The Complete Health Improvement Program
- Where
- United States
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Ohio University
Breast Neoplasm, Hereditary Neoplastic Syndrome
Microarray Analysis for Human Genetic Disease
This study will look at genetic changes which occur in the development of male and female breast cancer and other cancer. It will use a new technology called DNA microarray hybridization that looks at a wide array of genes to…
- Conditions
- Breast Neoplasm, Hereditary Neoplastic Syndrome, Melanoma, Ovarian Neoplasm
- Trial name
- NCT00001898
- Where
- 8 sites in United States, Finland and 2 more
- Volunteers
- 1,500 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Alzheimer's Disease (AD), Neurodegenerative Disease
A Biomarker-chip Assay in Preserved Red Blood Cells for the Diagnosis of Alzheimer's Disease
The ADCHIP study (ST0067) is a non-interventional, monocentric, prospective study conducted by Amoneta Diagnostics and the Leenaards Memory Center (Lausanne, Switzerland).
- Conditions
- Alzheimer's Disease (AD), Neurodegenerative Disease, Dementia, Frontotemporal Dementia (FTD)
- Trial name
- ADCHIP (NCT07307872)
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Male Infertility, Infertility, Male
The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor
Microfluidic chips are one of the methods of sperm separation to eliminate DNA fragmentation in sperm. It is thought that the separation of sperm by centrifugation in the classical gradient density (Percoll) method used in sperm…
- Trial name
- NCT03960229
- Testing
- MicroFluidic Sperm Sorting Chips, Gradient-Density Centrifugation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Wounds and Injuries, Closed Head Injury
Study of Sand Versus Wood Chip Surfaces on School Playgrounds to Minimize Injury in School Children
This study will compare children's injury rates (arm fracture, head injury and other injuries) when playing on playground equipment on granite sand versus wood fibre playing surfaces.
- Trial name
- NCT00213174
- Testing
- school playgrounds
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- The Hospital for Sick Children
Atrial Fibrillation
Intra-Cardiac Echocardiography Guided Cardioversion(ICE-CHIP) Study
This is a sequential phase 1 and phase 2 study to evaluate the efficacy of intracardiac echocardiography to detect septal and left atrial pathology as compared to transesophageal echocardiography (Phase 1) and its value in a…
- Trial name
- ICE-CHIP (NCT00281073)
- Testing
- Intra-Cardiac Echocardiography guided Cardioversion, Intracardiac Echo, ICE
- Where
- 6 sites in United States, Netherlands
- Volunteers
- 95 people
- Sponsor
- EP MedSystems
Lung Cancer Non-small Cell Stage IV
Evaluation of Efficacy and Toxicity of Nivolumab Monotherapy for Advanced Non-small Cell Lung Cancer After First-line Treatment Failure Based on Second-generation Sequencing and Liquid Chip Platform
In order to understand the efficacy and side effects of lung cancer immunotherapy, at least 30 patients with lung cancer who were treated with immunotherapy were enrolled.
- Trial name
- NCT03692442
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Covid19
Large-scale COVID-19 Population Screening
Infectious diseases pose a threat to the life of individuals worldwide. The pandemic has highlighted the need to develop an innovative and cost- effective large population-based screening methodology.
- Trial name
- NCT04847804
- Where
- 3 sites in Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology
Acute Myeloid Leukemia in Children
CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients
The CHIP-AML22 Master protocol has the overall aim of increasing the cure rate in newly diagnosed pediatric de novo AML patients, while avoiding unnecessary toxicity.
- Trial name
- CHIP-AML22/Q (NCT06262438)
- Testing
- Quizartinib, Etoposide, Dexrazoxane
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Heart Failure With Preserved Ejection Fraction
CHIP in Endothelial Dysfunction Associated With HEpEF
This study aims at identifying processes that are deregulated in blood cells by Clonal Hematopoiesis of Indeterminate Potential (CHIP) which are involved in the development of heart failure with preserved ejection fraction…
- Trial name
- CHiEF (NCT05828888)
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bordeaux
Consumer Behavior, Consumer Preference
Impact of Chip Thickness and Size on Eating Responses
To analyze prototypes developed with the base and seasonings of products that exhibit variations in chip thickness and size. The information obtained from this analysis will serve as the basis for subsequent research to explore…
- Conditions
- Consumer Behavior, Consumer Preference, Consumer Satisfaction
- Trial name
- NCT06691958
- Testing
- Tortilla corn chips 4-5 pieces, eat one piece at time, Tortilla corn chips 90 grams, Extruded corn chips 90 grams
- Where
- United Kingdom
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D