Clinical trials: CCT
Breast Cancer
Cardiotoxicity of Cancer Therapy (CCT)
The objective of this study is to define the clinical significance of mechanistic biomarkers (including Neuregulin-1Beta) and novel echocardiographic measures of cardiac function in predicting the incident risk of cancer therapy…
- Trial name
- NCT01173341
- Testing
- Echocardiography, Blood Collection, Symptoms Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Post-Acute COVID-19, Post Acute COVID-19 Syndrome
Safety and Dosage of a Computerized Cognitive Training Program for Cognitive Dysfunction After COVID-19
The goal of this Phase I/II clinical trial is to assess the safety and maximum tolerated training time of a self-administered computerized cognitive training (CCT) in individuals with cognitive dysfunction as a consequence of…
- Conditions
- Post-Acute COVID-19, Post Acute COVID-19 Syndrome, Cognitive Dysfunction, Cognitive Impairment
- Trial name
- CCTLongCOVID (NCT05582603)
- Testing
- CCT Long COVID
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio de Nebrija
Mild Cognitive Impairment
Assessing and Improving the Durability of Compensatory Cognitive Training for Older Veterans
Veterans have numerous risk factors (e.g., Post-traumatic stress disorder (PTSD), traumatic brain injury (TBI), cerebrovascular problems) for later-life cognitive and functional decline.
- Trial name
- AID-CCT (NCT05770479)
- Testing
- Motivationally-Enhanced Compensatory Cognitive Training (ME-CCT) Booster Modules, Treatment As Usual
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Rare Fetal Genetic Diseases, Congenital Malformation
Characterization and Contribution of Genome-wide DNA Methylation (DNA Methylation Episignatures) in Rare Diseases With Prenatal Onset
It is necessary to define reference DNA Methylation Episignatures from fetal DNA. The hypotheses are: It is possible to define reference DNA Methylation Episignatures from fetal DNA extracted from amniotic fluid or frozen tissues…
- Trial name
- FOETEPISIGN (NCT06475651)
- Testing
- Methylation analysis
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury, Trauma
The Neuromarker S-100B in Patients With Different Types of Intracranial Injury
Abstract: The most widely studied neuro-markers in traumatic brain injury (TBI) are S100B and neurone specific enolase (NSE). S-100B is localized in astroglia.
- Trial name
- NCT01619293
- Where
- Austria
- Volunteers
- 1,800 people
- Sponsor
- Medical University of Vienna
Wellbeing, Mental Health
Many Trauma-affected Youth Face Long Waits for Therapy, Worsening Stress, and Avoidance. CISS, a 90-minute Session Based on Stanford's Cue-Centered Therapy, Offers Coping Tools and Psychoeducation During This Gap. This Pilot Tests CISS's Feasibility, Acceptability, and Impact on 30-40 Adolescents.
Many young people who have experienced traumatic events such as sexual assault, domestic violence, serious accidents, or natural disasters face long waits before they can begin full trauma-focused therapy.
- Conditions
- Wellbeing, Mental Health, Psychological, Stress
- Trial name
- CISS (NCT07558005)
- Testing
- Cue-Centered Therapy (CCT)-Informed Single Session Intervention (CISS)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Anemia
Effectiveness and Acceptability of Weekly Iron Folic Acid Supplementation With Conditional Cash Transfer (WIFASCCT) Among Adolescent Girls in Four Districts of Pakistan in Low Income Setting
In Pakistan, adolescent girls aged 15-19 years are particularly vulnerable to anemia and malnutrition, with over half (54.7%) being anemic.
- Trial name
- NCT06733844
- Testing
- Weekly iron folic acid supplementations
- Where
- Pakistan
- Volunteers
- 2,131 people
- Sponsor
- Aga Khan University
Bladder Cancer
Phase II Gemcitabine + Cisplatin +/- Iressa Bladder CCT
The primary objective of the study is to assess the activity of ZD1839 250 mg once daily in addition to the standard chemotherapy in patients with advanced or metastatic transitional cell carcinoma of the urothelium by estimating…
- Trial name
- NCT00246974
- Testing
- Gemcitabine, Cisplatin, Gefitinib
- Where
- 14 sites in Germany
- Volunteers
- 125 people
- Sponsor
- AstraZeneca
Renal Cell Carcinoma
Safety and Efficacy of CCT301 CAR-T in Adult Subjects With Recurrent or Refractory Stage IV Renal Cell Carcinoma
This is a two arm, open-label, dose escalation and dose expansion clinical study to evaluate the safety and efficacy of infusion of autologous CCT301-38 or CCT 301-59 T cells in adult subjects with relapsed and refractory stage…
- Trial name
- NCT03393936
- Testing
- CCT301-38, CCT301-59
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai PerHum Therapeutics Co., Ltd.
Missing Tooth/Teeth
Abutment Hydrophilicity on Soft Tissue Morphogenesis
The goal of this clinical trial is to evaluate the effect of abutment surface bioactivation via argon plasma treatment on peri-implant soft tissue healing and integration in adult patients undergoing implant therapy.
- Trial name
- NCT07082088
- Testing
- the test group were placed in an Argon plasma reactor
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paolo Pesce
Myocardial Infarction
CCT for Comprehensive Risk Stratification Following STEMI
The CT-STEMI study aims to evaluate a comprehensive cardiac computed tomography (CCT) protocol for assessing the risk of heart failure (HF), life-threatening arrhythmias (LTA), and atherothrombotic events following ST-elevation…
- Trial name
- CT-STEMI (NCT06020209)
- Testing
- Cardiac Computed Tomography, Cardiac Magnetic Resonance
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Mild Cognitive Impairment
Effects of tACS Combined With CCT for Patients With MCI
This goal of this study is to explore the effects of transcranial alternating current stimulation(tACS) combined with computerized cognitive training(CCT) on improving cognition for patients with mild cognitive impairment(MCI).
- Trial name
- NCT04135742
- Testing
- Transcranial Alternating Current Stimulation, Cognitive Training
- Where
- 2 sites in China
- Volunteers
- 195 people
- Sponsor
- Shanghai Mental Health Center
Mindfulness, Compassion
Psychological and Neurobiological Impact of a Retreat Based on Mindfulness and Compassion for Stress Reduction.
The study is aimed at comparing the differential effects of two widely used standardized meditation programs: Mindfulness-Based Stress Reduction (MBSR) and Compassion Cultivation Training (CCT) delivered in a retreat format with…
- Conditions
- Mindfulness, Compassion, Psychophysiologic Reaction, Psychological Distress
- Trial name
- Retreat (NCT05516355)
- Testing
- Mindfulness-Based Stress Reduction, Compassion Cultivation Training
- Where
- Spain
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Chaperonin-Containing TCP-1, Circulating Tumor Cells
Liquid Biopsy Collection Study
The purpose of this study is to develop a liquid biopsy approach for detection of circulating tumor cells (CTC) that could be used in place of the more invasive and potentially risky methods of tissue biopsy.
- Conditions
- Chaperonin-Containing TCP-1, Circulating Tumor Cells, CCT, CTC
- Trial name
- NCT06068348
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Trauma Coagulopathy
Viscoelastic Tests (VET) Versus Conventional Coagulation Tests (CCT) for Management of Trauma-Induced Coagulopathy
Traumatic coagulopathy is a complex, multifactorial event that occurs in 20-30% of patients on admission. It increases mortality, and its treatment is one of the main priorities in the early management of severely injured…
- Trial name
- VISCOTAC (NCT06820879)
- Testing
- Viscoelastic Tests (ROTEM)
- Where
- 7 sites in France
- Volunteers
- 316 people
- Sponsor
- Hospices Civils de Lyon
Stress Disorders, Post-Traumatic
Child Characteristics, Neuromarkers, and Intervention Components Impacting Treatment Outcome: CCT, TF-CBT, TAU
This study is designed to examine three treatment conditions for traumatized youth: Cue-Centered Treatment (CCT), Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT), and Treatment as Usual (TAU) to determine which treatment…
- Trial name
- NCT02926677
- Testing
- Cue-Centered Treatment (CCT), Trauma-Focused CBT (TF-CBT), Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- Stanford University