Clinical trials: Burns
Burn Injury
Assessing Bioavailability of CoQ10 Supplementation in Burn Patients
To test the hypotheses that plasma and intracellular coenzyme Q10 levels will decline after burn injury and that ubiquinol supplementation will increase plasma and intracellular coenzyme Q10 levels in burn patients.
- Trial name
- CoQ10 (NCT02251626)
- Testing
- coenzyme Q10
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Second-degree Burn Wounds, Skin Graft Wounds
Efficacy of a Transparent Silicone Membrane With Physical Microstructure for Second-degree Burn Wounds and Skin Graft Wounds
The goal of this clinical trial is to comparison of physical microstructure-modified transparent silicone films and current conventional trauma dressings for second-degree burn wounds and post-skin graft wounds.The main question…
- Trial name
- NCT06170008
- Testing
- Physical microstructure-modified transparent silicone film sheet, Decellularized pig skin, Vaseline gauze
- Volunteers
- 40 people
- Sponsor
- Changhai Hospital
Burn, Surgery
A Randomized, Controlled Trial of the Effectiveness of Perioperative Antibiotics for Reduction of Burn Wound Bacterial Concentration Following Grafting
The purpose of this study if to evaluate the effectiveness of prophylactic antibiotics given during surgery in reducing the concentration of bacteria in a burn wound after surgery.
- Conditions
- Burn, Surgery, Infection Wound
- Trial name
- NCT04516148
- Testing
- Cefazolin, Clindamycin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Medstar Health Research Institute
Burn Injury
Amino Acid Supplementation in Recovery From Severe Burns
Exercise during recovery is now Standard of Care at Shriners Hospital for Children Galveston, since positive effects of exercise training were found on lean body mass and recovery after burns.
- Trial name
- ExAA (NCT01618630)
- Testing
- EAA Supplementation + Exercise Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Spinal Cord Injuries, Polytrauma
Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Intensive Rehabilitation
The use of conditioning open-label placebo (COLP) will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury.
- Conditions
- Spinal Cord Injuries, Polytrauma, Burn Injury, Pain Management
- Trial name
- COLP (NCT03906721)
- Testing
- Oxycodone, Essential Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Scars
Autologous Nanofat Grafting by Injection Versus With Microneedling in Post-burn and Traumatic Atrophic Scars
This study aims to evaluate the efficiency autologous nanofat injection versus autologous nanofat delivered by microneedling in management of post burn atrophic and traumatic scars.
- Trial name
- NCT06566300
- Testing
- injection of autologous nanofat grafting, microneedling with autologus nanofat graft
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Skin Burn Multiple
Ability of Modulated Imaging and Laser Speckle Imaging to Determine Burn Wound Severity and Healing Potential
According to the National Burn Repository 2007, the most common type of burn injury is a partial thickness burns. The current standard of care for partial thickness burns is two weeks of topical therapy and wound care.
- Trial name
- NCT01166893
- Testing
- Modulated Imaging and Laser Speckle Imaging
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, Irvine
Burn Scar
Comparative Study Between Fat Injection And Platelet Rich Plasma In Post Burn Facial Scar
Best method in management of facial burn scar
- Trial name
- NCT04557514
- Testing
- platelet rich plasma injection in post burn facial scar, fat injection in post burn facial scar
- Volunteers
- 60 people
- Sponsor
- Assiut University
Tobacco Use Disorder
Comparative Abuse Liability Among African American and White Smokers
The study is a randomized crossover trial. Current smokers will complete a session with each product: usual brand cigarette, e-cigarette, and heat-not-burn.
- Trial name
- NCT04646668
- Testing
- E-cigarette and Heat not burn
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Anxiety, Pain
A Study of the Effectiveness of Virtual Reality Relaxation Combined With Patient-Controlled Analgesia (PCA) Morphine for Those Undergoing Burn Dressing Changes
The purpose of this study is to evaluate whether a sub-population of patients with burn injuries needing dressing changes respond to virtual reality (VR) utilising relaxation themes with improved pain and anxiety scores, when…
- Trial name
- NCT00163917
- Testing
- Virtual reality relaxation
- Where
- Australia
- Volunteers
- 90 people
- Sponsor
- Bayside Health
Trauma, Burns
Point of Care Testing of Cholinesterase Activity During Burn- and Polytrauma
Goal of this study is to measure serum cholinesterase activity in patients with traumatic and/or burns injury admitted to the emergency room by using point-of- care-test system (POCT).
- Trial name
- POCCET (NCT02691650)
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- University Hospital Heidelberg
Scar
Efficacy of Different Densities of Fractional Carbon Dioxide in Treatment of Post Burn Scars
This study aims to compare effectiveness of different densities of carbon dioxide fractional laser in the treatment of postburn scar.
- Trial name
- NCT03416660
- Testing
- Fractional Carbon Dioxide laser
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Cairo University
Second-degree Burn
Mepilex Ag vs. Xeroform in Pediatric Patients That Sustain Partial Thickness Burn Injury
Pediatric patients that sustain partial thickness burn injuries to their extremities require regular scheduled dressings and weekly appointments for better healing.
- Trial name
- NCT04149808
- Testing
- Mepilex Ag (burn dressing), Xeroform Dressing
- Where
- United States
- Sponsor
- Wayne State University
Open Burn Pit Exposure
DNA Methylation Markers in Veterans Exposed to Open Burn Pits
Background: The VA and DoD estimate that 3.5 million Veterans and Service Members were exposed to open burn pits used for waste disposal during military deployments to countries such as Kuwait, Afghanistan, and Iraq since 1990.
- Trial name
- NCT06305091
- Testing
- Health survey for physical and mental health comorbidities, epigenetic marker and heavy metals in blood and urine samples
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Central Arkansas Veterans Healthcare System
Third-degree Burns, Reconstructive Surgery
Evaluation of NEVELIA® in Terms of Safety and Efficacy for Third-degree Burns Treatment or Reconstructive Surgery
The dermal substitute NEVELIA® has received CE marking in July 9, 2013. Its use in the NEVAL protocol will be in accordance with its leaflet, i.e. for the treatment of burns or in case of reconstructive plastic surgery.
- Trial name
- NEVAL (NCT02089490)
- Testing
- NEVELIA® implantation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Symatese
Burnout, Professional, Mental Health Wellness 1
Burn Out Among Medical Family Doctors
The main objective of this study is to assess the burnout prevalence among French general practitioners in private practice. As secondary outcomes, this study aim to measure the impact of sociodemographic variables…
- Conditions
- Burnout, Professional, Mental Health Wellness 1, Anxiety, Depressive Disorder
- Trial name
- BOUM (NCT04242862)
- Where
- France
- Volunteers
- 1,536 people
- Sponsor
- University Hospital, Clermont-Ferrand
Inhalation Injury, Burn Injury
Trial of Nebulized Heparin Versus Placebo for Inhalation Trauma
The purpose of this international multi-center double-blind randomized placebo-controlled trial is to determine the effect of nebulized heparin, compared to placebo, on the number of ventilator-free days at day 28, in burn…
- Trial name
- Hepburn (NCT01773083)
- Testing
- unfractionated heparin
- Where
- 8 sites in Australia, Belgium and 1 more
- Volunteers
- 13 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Burns Surgery
Antibioprophylaxis for Excision-graft Surgery in Burn Patient (A2B-TRIAL)
The indication of antibiotic prophylaxis in burn patients remains highly controversial and hasn't reached a consensus. The objective of antibiotic prophylaxis would be to reduce the risk of post-operative local and systemic…
- Trial name
- A2B (NCT04292054)
- Testing
- active intervention
- Where
- France
- Volunteers
- 506 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thermal Burn
Feasibility of Obtaining ADRCs From Discarded Thermal Burn Eschar Tissue Using Investigational Celution® System
The objective of the study is to assess the logistical and biological feasibility of preparing ADRCs from adipose tissue excised during standard-of-care burn wound excision using the Celution® System for autologous, same-day…
- Trial name
- NCT02362386
- Testing
- Celution Device
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Cytori Therapeutics
Burns
The Effect of Two Versus Ten Days Application of Flammacerium in Partial Thickness Burns
The objective of the proposed study is to assess whether the application of flammacerium for 2 days is as good as, or even better than, the application of flammacerium for 10 days regarding woundhealing in partial thickness burns.
- Trial name
- NCT00156988
- Testing
- cerium nitrate-silver sulfadiazine (cerium-flamazine)
- Where
- Netherlands
- Sponsor
- Association of Dutch Burn Centres