Clinical trials: Burden
Cancer, Spinal Disease
Anderson Circulating Tumor Cell Burden (CTCB) Study
Phase 1 - Optimization Phase: Primary Objective: The primary objective of Phase 1 of this study is to determine the time point at which maximal Circulating Tumor Cell Burden (CTCB) occurs following standard vertebroplasty and…
- Conditions
- Cancer, Spinal Disease, Vertebral Compression Fractures
- Trial name
- NCT00819832
- Testing
- Kyphoplasty, Vertebroplasty, Cavity SpineWand
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Injuries
Impact and Burden of Rugby Injuries in Argentina. A Complete Season Retrospective Multicentric Study.
The aim of this study was to describe the prevalence, incidence and injury load suffered in male amateur rugby players from Argentina during a competitive season in 2019.
- Trial name
- ARugby (NCT04402567)
- Testing
- No Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hospital Donación Francisco Santojanni
Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic)
Regulating Emotions and Behaviors After Brain Injury
After acquired brain injury (ABI), persons can experience emotional and behavioral difficulties, that can be painful both for the person and his/her family.
- Conditions
- Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic), Brain Tumor (After Recovery), Encephalitis
- Trial name
- GREMO-LCA (NCT05393492)
- Testing
- Dialectical Behavior Therapy and Radically Open dialectical behavior therapy
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Heart Failure, Caregiver Burden
Effect of the PLAN CUIDARTE on the Caregiving Competence of People With Heart Failure
According to the World Health Organization (WHO), by 2021 cardiovascular diseases (CVD) will be a public health problem, among them heart failure (HF), since this is a chronic disease, patients should be competent in their care.
- Conditions
- Heart Failure, Caregiver Burden, Discharge Plan, Care Transitions
- Trial name
- PLANCUIDARTE (NCT06309875)
- Testing
- PLAN CUIDARTE, Conventional care
- Where
- Colombia
- Volunteers
- 84 people
- Sponsor
- Universidad de la Sabana
Caregiver Burden, Self Efficacy
An Online Ecoaching RCT Intervention for Carers: Enhancing Wellbeing and Resilience Through Self-Help Strategies
The goal of this three-armed, double-blind randomized controlled trial (RCT) is to compare the effectiveness of an online self-help eCoaching intervention designed for caregivers.
- Conditions
- Caregiver Burden, Self Efficacy, Quality of Life, Anxiety Depression
- Trial name
- NCT06604481
- Testing
- eCoaching for Caregivers of Older Adults, eCoaching (need specific) for Caregivers of Older Adults, Control Intervention for Caregivers of Older Adults
- Where
- Hong Kong
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pneumonia, Pneumonia - Bacterial
Urine Pneumococcal Antigen Project
Background: Pneumonia caused by the bacteria Streptococcus pneumoniae is a leading cause of death among children under five years of age, especially in sub-Saharan Africa.
- Trial name
- UPAP (NCT07181200)
- Where
- Malawi
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Atrial Fibrillation, Quality of Life
Evaluation of the Added Value of an Internet-based Educational Program for Patients With Atrial Fibrillation.
This study is prospective, open and randomized concerning the value of an Internet-based educational program for patients with atrial fibrillation compared to "care as usual".
- Conditions
- Atrial Fibrillation, Quality of Life, Signs and Symptoms, Health Economy
- Trial name
- AMADEUS (NCT03763500)
- Testing
- Internet-based education
- Where
- 3 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Ulla Walfridsson
Polycystic Ovary Syndrome, Psychological Distress
Development of the Polycystic Ovary Syndrome Symptoms Inventory
Polycystic Ovary Syndrome Symptom Severity and Distress Inventory: Development, Validity and Reliability in Turkey The goal of this observational study is to develop and validate a self-report inventory that assesses Polycystic…
- Trial name
- NCT07402980
- Where
- Turkey (Türkiye)
- Volunteers
- 227 people
- Sponsor
- Abant Izzet Baysal University
Lung Cancer, Chemoradiotherapy
Symptoms Burden in Lung Cancer Patients Undergoing Definitive Chemoradiotherapy: Insights From Electronic Patient-Reported Outcomes
This prospective observational study aims to evaluate symptom burden and symptom clusters among lung cancer patients undergoing definitive concurrent chemoradiotherapy (CRT), based on electronic patient-reported outcomes (ePROs).
- Conditions
- Lung Cancer, Chemoradiotherapy, Patient-Reported Outcomes (PRO)
- Trial name
- ePRO-LC-CRT (NCT07131670)
- Testing
- Electronic Patient-Reported Outcome Monitoring
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qian Chu
Alzheimer Disease, Dementia
STAR Caregivers - Virtual Training and Follow-up
This study evaluates the effectiveness of a caregiver outreach, training, and support program for caregivers of people with dementia who are using antipsychotic medication to manage agitation/aggression.
- Conditions
- Alzheimer Disease, Dementia, Caregiver Burnout
- Trial name
- STAR-C-VTF (NCT04271046)
- Testing
- STAR-C-VTF, Control
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Kaiser Permanente
Coronary Artery Disease, Hypercholesterolemia
A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma
The main aim of this trial is to demonstrate that Evolocumab plus routine lipid management is superior to routine lipid management alone in modifying plaque (non-calcified) volume as measured by Artificial Intelligence-enabled…
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Atheroma, Atherosclerotic Plaque
- Trial name
- NCT07803679
- Testing
- Evolocumab, Routine Lipid Management, Autoinjector
- Volunteers
- 308 people
- Sponsor
- Amgen
Breast Cancer, Lung Cancer
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study will investigate the effects of atezolizumab on select cancer types in people whose analysis of tumour DNA and RNA indicates they may be sensitive to atezolizumab.
- Conditions
- Breast Cancer, Lung Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- CAPTIV-8 (NCT04273061)
- Testing
- Atezolizumab
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Cerebral Palsy
Pain Burden in Children and Adolescents With Cerebral Palsy
Pain in children and adolescents with cerebral palsy (CP) is a significant health challenge that so far has received too little attention.
- Trial name
- CPPain (NCT04219020)
- Testing
- Co-created intervention
- Where
- 5 sites in United States, Canada and 3 more
- Volunteers
- 588 people
- Sponsor
- Sykehuset Telemark
Caregiving Stress, Caregiver Burden
SAGE LEAF 2: An Online Program to Reduce Dementia Caregiver Burden
The goal of this clinical trial is to learn if the SAGE LEAF (Social Augmentation of self-Guided Electronic delivery of the Life Enhancing Activities for Family caregivers) online positive emotion skill-building program delivered…
- Trial name
- SAGE LEAF 2 (NCT06708182)
- Testing
- SAGE LEAF Positive Emotion Skills Course
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Fibromyalgia, Interoception
The Role of Interoceptive Sensitivity in Central Sensitization Symptom Severity in Fibromyalgia
In fibromyalgia, the increased central sensitization symptom burden can lead to a disruption in the individual's interoception and difficulties in managing symptoms.
- Conditions
- Fibromyalgia, Interoception, Central Sensitization
- Trial name
- NCT07878286
- Testing
- Central Sensitization Inventory, The Multidimensional Assessment of Interoceptive Awareness scale-2, Revised Fibromyalgia Impact Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Age Related Macular Degeneration (ARMD), Retinal Vein Occlusion (RVO)
Comparison of Intravitreal Anti-VEGF Treatment Burden in Different Retinal Diseases
The study compares the perceived treatment burden in patients undergoing intravitreal anti-VEGF treatment for either wet age related macular degeneration, macular edema after retinal vein occlusions or diabetic macular edema.
- Conditions
- Age Related Macular Degeneration (ARMD), Retinal Vein Occlusion (RVO), Diabetic Macular Edema (DME)
- Trial name
- NCT07514559
- Where
- Austria
- Volunteers
- 393 people
- Sponsor
- Hospital Hietzing
Caregiver Burnout, Caregiver
Effect of Autogenic Relaxation Therapy on Caregivers on Perceived Stress Quality of Life and Caregiver Burden
Caregivers are also faced with multiple stress factors. Autogenic relaxation therapy will help caregivers relax and take time for themselves by getting away from the stressful life they have lived.
- Conditions
- Caregiver Burnout, Caregiver, Care Burden
- Trial name
- NCT06687486
- Testing
- relaxin, kontrol
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Seda KARAKAYA ERGUN
Nausea, Vomiting
Effect of a Symptom Diary on Symptom Care and Symptom Burden in Patients Treated With Chemotherapy: a Before-and-after-study
This study investigates whether the implementation of a symptom diary for reporting and communicating chemotherapy-related symptoms improves symptom care and decreases symptom burden in adult patients treated with chemotherapy.
- Conditions
- Nausea, Vomiting, Pain, Anorexia
- Trial name
- NCT02050490
- Where
- Belgium
- Volunteers
- 236 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atrial Fibrillation
Reduction in Arrhythmia Burden With Left Atrial Posterior Wall Ablation for Persistent AF
RABLAP-AF will compare pulmonary vein isolation (PVI) in combination with posterior wall isolation (PWI) for patients with persistent atrial fibrillation (AF).
- Trial name
- RABLAP-AF (NCT05195268)
- Testing
- Intracardiac Catheter Ablation
- Where
- United Kingdom
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Cancer, Cancers, Pain
Impact of Daily Oral Cannabis Doses in Patients With Cancer
This study will enroll patients with cancer and participants will be randomized to receive one dose of cannabis for approximately 4 months.
- Trial name
- NCT06601218
- Testing
- Oral cannabis low THC, Oral cannabis high THC, Oral cannabis THC/CBD
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shanna Babalonis, PhD