Clinical trials: Buprenorphine
Opioid Use Disorder, Substance-Related Disorders
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
The goal of this observational study is to learn about the long term effects of prenatal opioid exposure. The main objectives are: Long term goal: to improve the safety and efficacy of maternal Opioid Use Disorder (OUD) and…
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Pregnancy Related, Narcotic-Related Disorders
- Trial name
- NCT06415994
- Testing
- Buprenorphine or Methadone Treatment, Fetal and Placental MRI, Child Developmental Assessment
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Opioid Use Disorder, Peer Recovery Supporters
Peer Recovery Support for Opioid Use Disorder Treatment Retention
The goal of this clinical trial is to learn whether adding peer recovery support services to standard opioid use disorder (OUD) treatment in primary care helps patients stay in treatment longer.
- Conditions
- Opioid Use Disorder, Peer Recovery Supporters, Peer Recovery Coaching, Primary Care
- Trial name
- NCT07620171
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid Use Disorder, Substance-Related Disorders
Maternal Brain Imaging in Opioid Use Disorder
This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved.
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related
- Trial name
- NCT06008990
- Testing
- Buprenorphine, Maternal Brain MRI, Blood Samples
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid-use Disorder, Opioid Use, Unspecified
Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution…
- Conditions
- Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence
- Trial name
- Mother/BabyOUD (NCT03923374)
- Testing
- Subutex / Buprenorphine, Fetal & Neonatal MRI, DNA/Genetic/Pharmacokenetic Blood Draws
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Opioid-Related Disorders, Buprenorphine
Developing a Tailored Stigma Reduction Intervention to Increase Buprenorphine Prescribing
Buprenorphine is an evidence-based treatment for opioid use disorder that also has strong potential to reduce HIV transmission in people who use drugs.
- Conditions
- Opioid-Related Disorders, Buprenorphine, Social Stigma, Rural Health Services
- Trial name
- NCT05505227
- Testing
- Stigma-reduction training
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ohio University
The Effect of S-ketamine on Pharmacokinetics of Morphine, Hydromorphone, and Buprenorphine
KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine
S-ketamine is often administered as a part of multimodal analgesia to reduce postoperative pain and postoperative opioid consumption.
- Trial name
- KetaMoHydBup (NCT05571176)
- Testing
- S-ketamine
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Elina Brinck
Rotator Cuff Tear, Rotator Cuff Injury
Buprenorphine Transdermal Patches in Arthroscopic Rotator Cuff Repair
Arthroscopic rotator cuff repair is associated with poor post-operative pain management. The multimodal analgesic scheme (oral non-steroidal anti-inflammatory drugs associated with oral opioids) currently used according to the…
- Conditions
- Rotator Cuff Tear, Rotator Cuff Injury, Analgesics, Opioid, Buprenorphine
- Trial name
- NCT03380533
- Testing
- Buprenorphine, Multimodal Oral Scheme, Tramadol
- Where
- Argentina
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
HIV-1-infection, Hepatitis C, Chronic
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy
The study hypothesis is to determine the feasibility of switching HIV-HCV co-infected patients receiving methadone or buprenorphine/naloxone as opioid substitution therapy with suppressed HIV RNA viral load on current…
- Conditions
- HIV-1-infection, Hepatitis C, Chronic, Methadone Dependence, Opioid Dependence
- Trial name
- NCT03549312
- Testing
- Genvoya, Epclusa, Biktarvy
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Opioid-related Disorders, Buprenorphine
Neurocognitive Effects of Buprenorphine Among HIV+ and HIV-Opioid Users
The purpose of this study is to examine how Buprenorphine, a form of opioid addiction treatment, changes the ability to think and reason among people addicted to opiates, who are either HIV negative or HIV positive.
- Conditions
- Opioid-related Disorders, Buprenorphine, HIV, Cognition
- Trial name
- NCT01108679
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Pharmacokinetics and Pharmacodynamics of Sublingual Buprenorphine
Effects of Posaconazole and Voriconazole on the Pharmacokinetics and Pharmacodynamics of Sublingual Buprenorphine
Variability in drug response can be due to either pharmacokinetic or pharmacodynamic factors. The reasons why people differ in pharmacokinetics or pharmacodynamics are manifold and include, e.g., genetic factors, diseases, age…
- Trial name
- PosaBupre (NCT01367808)
- Testing
- vorikonazole, posakonazole
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital