Clinical trials: Bronchoscopy
Respiratory Diseases
Bronchoscopy Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects
The purpose of this research study is to collect cells and liquid from the air passages of healthy adults, both smokers and non-smokers.
- Trial name
- SCCOR Bronch (NCT00840723)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Patients Undergoing Rigid Bronchoscopy
A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor
Standard ASA fasting guidelines will be followed. IV 20 gauge cannula will be inserted and dedicated to the infusion drugs. Standard ASA monitors will be attached, and baseline heart rate (HR), mean arterial blood pressure (MAP)…
- Trial name
- NCT07409935
- Testing
- Propofol saline, Propofol Dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Respiratory Tract Diseases
Safety and Accuracy of Alveoscopy in Interstitial Lung Diseases
Fibered confocal fluorescence microscopy (FCFM), also referred to as Cell-Vizio® (MaunaKea Technologies, France) is a new technique that produces microscopic imaging in a living tissue, through a 1 mm fiberoptic miniprobe that…
- Trial name
- ALVEOLE (NCT00377338)
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Asthma
Bronchoscopy With Bronchial Biopsies Sub-study of: Persistence of Airway Inflammation and Remodeling in Asthma Remission
This study aims at determining the patterns of asthma remission, the prevalence of these different patterns and the various factors associated with such remissions and possible recurrences of asthma, in order to determine the…
- Trial name
- NCT00526344
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Laval University
Flexible Fiberoptic Bronchoscopy Versus Flexible Intubation Video Endoscope FIVE in Obese Patients
Comparison of Endotracheal Intubation Using Flexible Fiberoptic Bronchoscopy Versus Flexible Intubation Video Endoscope (FIVE) in Obese Patients Undergoing Elective Surgeries Under General Anesthesia: A Randomized Controlled Trial
Tracheal intubation is one of the most common medical procedures performed in hospitals. On one hand, it is highly successful and easy to perform using a rigid laryngoscope.
- Trial name
- NCT03423563
- Testing
- Flexible fiberoptic bronchoscopy, Fexible intubation video endoscopy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulmonary Fibrosis, Rheumatoid Arthritis
Specimen Collection for Individuals With Lung Disease Associated With Rheumatoid Arthritis
Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA).
- Trial name
- NCT00001884
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bronchoscopy
Bronchoscopy and Bispectral Index (BIS) - Guided Sedation
Bronchoscopy is performed on a daily basis for diagnostic and therapeutic purposes. This procedure may cause anxiety and discomfort requiring the use of sedative drugs.
- Trial name
- NCT00839371
- Testing
- Propofol, Midazolam
- Where
- Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Airway Disease
Airway Pressure and Lumen Changes During NIV With Flexible Bronchoscopy
Introduction: The non-invasive ventilation (NIV) of continuous nasopharyngeal O2 with intermittent close/open nose and abdomen compression (PO2-NC-AC) can provide effective oxygenation, ventilation and circulation.
- Trial name
- NCT03666403
- Testing
- NIV rate: 0/min, NIV rate: 10-20/min, NIV rate: 5-10/min
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Anesthesia Intubation Complication
Video-stylet for Nasotracheal Intubation in Limited Mouth Opening Patient
The aim of the study is to investigate the efficiency of the Video-stylet (Trachway ®) and the fiberoptic bronchoscopy in facilitation of nasotracheal intubation in limited mouth opening patients.
- Trial name
- NCT01917435
- Testing
- video-stylet, fiberoptic bronchoscope
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Conscious Sedation, Patient Satisfaction
Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy
In this study, the investigators plan to conduct a single blinded randomized controlled trial in the Pulmonary Service to demonstrate the efficacy of ketamine and its utility in moderate sedation.
- Conditions
- Conscious Sedation, Patient Satisfaction, Ketamine
- Trial name
- NCT06181188
- Testing
- Ketamine, Midazolam, Fentanyl
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Acute Lung Inflammation
Effects of Bronchial Segmental Endotoxin Instillation in Humans
Background: When bacteria enter the lungs, serious infections can occur. Researchers want to learn more about the process of inflammation in the lungs by studying lung cells and the products that they make.
- Trial name
- NCT02392442
- Testing
- Saline, Endotoxin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Asthma
Comparison Of Molecular Targets In Mild To Severe Asthmatics And Healthy Subjects
The primary goal of this study is to compare the expression of key GSK drug targets across the 4 asthma phenotypes and healthy subjects and secondarily to evaluate changes in target expression in response to a 2-week course of…
- Trial name
- NCT00331058
- Testing
- Bronchoscopsy, Prednisolone
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma
Severe Asthma Research Program (SARP)- San Francisco Clinical Site
The mission of SARP is to improve the understanding of severe asthma through integrated study of its clinical and biological features and to evaluate their changes over time.
- Trial name
- SARP (NCT01718197)
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Intubating Conditions, Fasciculations
Muscle Relaxation for Short Procedures
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application of low-dose rocuronium, reversed by low-dose sugammadex.
- Conditions
- Intubating Conditions, Fasciculations, Postoperative Myalgia, Patient Satisfaction
- Trial name
- NCT01902641
- Testing
- Succinylcholine, Rocuronium/Sugammadex, Rocuronium
- Where
- Germany
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers
Smoking damages the airway epithelium. The major mechanism by which this is done is by molecules called free radicals. Our body attempts to deal with these damaging molecules in two ways.
- Trial name
- NCT00565214
- Testing
- Group 1, Group 2
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Nasotracheal Intubation
Nasotracheal Intubation in Children for Outpatient Dental Surgery
The aim of study was to compare the hemodynamic responses and adverse events associated with nasotracheal intubation (NTI) using a fiberoptic bronchoscope (FOB) and a direct laryngoscope (DLS) in children undergoing general…
- Trial name
- NCT02993692
- Testing
- Direct laryngoscopy and fiberoptic bronchoscopy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Inonu University
Adverse Effects
Optimal TCI Regimen for Sedation of Elderly Undergoing Fiberoptic Bronchoscopy
Target-Controlled Infusion (TCI) of Propofol has been proved to be a safe agent for conscious sedation in flexible bronchoscopy (FB) .However, the target setting of "effect-site" concentration (Cet) of propofol is still unclear…
- Trial name
- NCT02927587
- Testing
- The induction Cet of propofol
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Intubating Conditions, Postoperative Myalgia
Comparing Intubating Conditions Using Succinylcholine or Rocuronium for Rigid Bronchoscopy
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application aof rocuronium, reversed by sugammadex.
- Conditions
- Intubating Conditions, Postoperative Myalgia, Patient Satisfaction
- Trial name
- NCT01996358
- Testing
- Succinylcholine, Rocuronium 0,3, Rocuronium 0,6
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Asthma, Mucus; Plug, Tracheobronchial
Study of Focal Airway Disease in Asthma Using Image Guided Bronchoscopy
This is a single center study of 60 subjects including those with asthma and mucus plugging, those with asthma and without mucus plugging, and healthy controls.
- Trial name
- SOFA (NCT04514913)
- Testing
- Multidetector Computed Tomography (MDCT) Scan, Virtual Navigation Bronchoscopy (VNB)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco