Clinical trials: Bronchiolitis
Bronchiolitis, Respiratory Disease
Isotonic Saline for Children With Bronchiolitis
The goal of this randomized clinical trial is to investigate the optimal supportive treatment of bronchiolitis in infants from 0-12 months of age.
- Conditions
- Bronchiolitis, Respiratory Disease, Asthma in Children, Viral Infection
- Trial name
- NCT05902702
- Testing
- Nebulized isotonic saline, Nasal irrigation with isotonic saline
- Volunteers
- 300 people
- Sponsor
- Slagelse Hospital
Bronchiolitis
Bronchiolitis Recovery and the Use of High Efficiency Particulate Air (HEPA) Filters
This is a multi-center, parallel, double-blind, randomized controlled clinical trial. Children <12 months of age hospitalized with bronchiolitis are randomized 1:1 to receive a 24-week home intervention with filtration units…
- Trial name
- BREATHE (NCT05615870)
- Testing
- Winix 5500-2 HEPA filtration units
- Where
- 17 sites in United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- IDeA States Pediatric Clinical Trials Network
Wheezing, Bronchiolitis
Bedside Lung Ultrasound in Young Children Presenting to the Emergency Department (ED) With Wheezing
Young children presenting to the Emergency Department (ED) with wheezing often have prolonged stays in the ED or even get admitted to the hospital.
- Trial name
- NCT01452945
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's National Research Institute
Chronic or Recovered Hepatitis B, Chronic or Recovered Hepatitis C
Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver Disease
Background: The COVID-19 global pandemic killed more than 6 million people worldwide. Several vaccines have been developed against the virus that causes this disease.
- Conditions
- Chronic or Recovered Hepatitis B, Chronic or Recovered Hepatitis C, Chronic or Recovered Hepatitis D, NAFLD
- Trial name
- NCT05669677
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Bronchiolitis, Clinical Phenotype
Short-Term Enteral Nutrition for Infants With Bronchiolitis in Pediatric Emergency Departments
Bronchiolitis is a common viral infection of the small airways that affects infants, particularly during respiratory syncytial virus epidemics.
- Conditions
- Bronchiolitis, Clinical Phenotype, Nutritionnal Impairment, Short-Term Enteral Nutrition
- Trial name
- STENP-PER (NCT07901400)
- Testing
- Usual inpatient bronchiolitis care, STENP-PER care pathway
- Where
- 8 sites in France
- Volunteers
- 448 people
- Sponsor
- Hospices Civils de Lyon
Bronchiolitis
Comparing Nasal Suction Devices in Children With Bronchiolitis: A Pilot Study
The purpose of our study is to determine the safety, efficacy, length of stay and parental satisfaction of the NoseFrida in comparison to a suction device used in the hospital setting in patients with bronchiolitis admitted under…
- Trial name
- NCT02219334
- Testing
- NoseFrida
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Baylor College of Medicine
Chronic Graft Versus Host Disease
Bortezomib Plus Prednisone for Initial Therapy of Chronic Graft Versus Host Disease
The purpose of this research study is to determine the effectiveness of bortezomib (Velcade) plus prednisone for treating chronic graft versus host disease (cGVHD) and the safety of this drug combination in this patient…
- Trial name
- NCT00815919
- Testing
- bortezomib, Prednisone
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Dana-Farber Cancer Institute
Bronchiolitis, Hypoxemia
Heated Humidified Oxygen Compared to Dry Oxygen Therapy in Children With Bronchiolitis
The purpose of this study is to compare heat and humidified oxygen with cold and dry oxygen in children with bronchiolitis. The hypotheses are that heating and humidifying inspired low flow supplemental oxygen will optimize…
- Trial name
- NCT02094664
- Testing
- Heated and humidified oxygen
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Acute Bronchiolitis
High Flow Nasal Cannula Weaning in Acute Bronchiolitis
The goal of this clinical study is to compared two different strategies to end high flow nasal cannula treatment in acute bronchiolitis.
- Trial name
- NCT06321133
- Testing
- High flow nasal cannula immediate ending, High flow nasal cannula weaning
- Where
- 4 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Kuopio University Hospital
Pulmonary Disease, Chronic Obstructive
A Study of Exercise Endurance and Lung Hyperinflation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
This study evaluated the effect of inhaled aclidinium bromide on exercise endurance and in reducing resting and dynamic lung hyperinflation in patients with moderate to severe COPD.
- Trial name
- NCT00500318
- Testing
- Aclidinium Bromide
- Where
- 52 sites in United States, Canada
- Volunteers
- 181 people
- Sponsor
- AstraZeneca
Low Back Pain, Mechanical
Effectiveness of Tricortin 1000 in Patients Affected by Chronic Low Back Pain
PAES, double blind, double dummy, multicenter, randomized, controlled clinical study to demonstrate superiority of Tricortin 1000 over placebo in improvement in pain relief as change from baseline to 15 days in patients with…
- Trial name
- NCT04585334
- Testing
- Tricortin 1000, Itami
- Where
- 13 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Joint Instability, Chronic Disease
Jumping Exercises Approach in Individuals With Chronic Ankle Instability
The aim of this pilot study is to analyze the effect of a 12-week specific jump training compared with conventional therapy in patients with chronic functional instability of the ankle.
- Conditions
- Joint Instability, Chronic Disease, Sprains
- Trial name
- NCT02115971
- Testing
- Jumping exercise, Strength exercise
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Swanenburg
Chronic and Non-healing Wounds
Investigating the Benefits of a 3D Camera for Recording Healing Wound Dimensions
The study will explore whether a 3D camera data can provide a more accurate baseline measurement (compared to 2D images with manual measurement) to support better clinical decision making in referrals to tissue viability.
- Trial name
- NCT03355599
- Testing
- 3d camera
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Bronchiolitis
Nebulised 3% Hypertonic Saline Versus 0.9% Saline for Treating Patients Hospitalized With Acute Bronchiolitis
Bronchiolitis is an acute viral infection of the lower respiratory tract. It is most commonly caused by respiratory syncytial virus (RSV).
- Trial name
- NCT06069336
- Testing
- Hypertonic saline, Normal saline
- Where
- 3 sites in Poland
- Volunteers
- 180 people
- Sponsor
- Szpital im. Św. Jadwigi Śląskiej
Cholecystitis, Chronic
Bikini Scarless Laparoscopic Cholecystectomy for Morbid Obesity as a Day Case.
Background: Bikini line laparoscopic cholecystectomy is a safe method, used as a scarless cosmetic port technique for gall bladder diseases in morbid obese patients as a day case.
- Trial name
- NCT04836598
- Testing
- laparoscopic cholecystectomy
- Where
- 4 sites in Egypt, Saudi Arabia
- Volunteers
- 3 people
- Sponsor
- Zagazig University
Chronic Graft Versus Host Disease, Hematologic and Lymphocytic Disorder
Allogeneic CD6 Chimeric Antigen Receptor T Regulatory Cells (CD6-CAR Tregs) for the Treatment of Patients With Chronic Graft Versus Host Disease After Allogeneic Hematopoietic Cell Transplantation
This phase I trial tests the safety, side effects, and best dose of allogeneic CD6 chimeric antigen receptor T regulatory cells (CD6-CAR Tregs) in treating patients who have chronic graft versus host disease (cGVHD) after an…
- Conditions
- Chronic Graft Versus Host Disease, Hematologic and Lymphocytic Disorder, Steroid Refractory Graft Versus Host Disease
- Trial name
- NCT05993611
- Testing
- Biopsy, Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- City of Hope Medical Center
Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia
Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients.
To evaluate the safety, efficacy and pharmacokinetics of nilotinib over time in the Ph+ chronic myelogenous leukemia (CML) in pediatric patients (from 1 to <18 years).
- Trial name
- DIALOG (NCT01844765)
- Testing
- nilotinib
- Where
- 36 sites in United States, France and 11 more
- Volunteers
- 59 people
- Sponsor
- Novartis Pharmaceuticals
Acute Bronchiolitis
Evaluation of the Effects of Respiratory Physiotherapy in Infants With Moderate Acute Bronchiolitis
Bronchiolitis affects 460,000 children in France per year. The French study called "Bronkilib 2" found a positive effect of chest physiotherapy treatment.
- Trial name
- Bronkiville (NCT03753802)
- Testing
- Chest Physiotherapy, Surveillance
- Where
- 3 sites in France
- Volunteers
- 168 people
- Sponsor
- Réseau Kinésithérapie Bronchiolite Essonne
Bronchiolitis, Respiratory Syncytial Virus (RSV)
High Flow Nasal Cannula Therapy in Bronchiolitis : Early vs Rescue
The enrolled RSV-bronchiolitis patients will be randomized into two arms , the early HHHFNC group and the standard therapy group with rescue HHHFNC to study the efficacy of this treatment.
- Trial name
- NCT03095495
- Testing
- Heated Humidified High Flow Nasal Cannula, Standard Therapy (Low Flow Nasal Cannula)
- Where
- Qatar
- Volunteers
- 28 people
- Sponsor
- Hamad Medical Corporation
Graft Versus Host Disease (GVHD), Acute Myocardial Infarction (AMI)
University of Wisconsin hMSC Cell Bank: Bone Marrow Donor Protocol
The objective of this protocol is to use established standard criteria and methods for the collection of hMSC (human mesenchymal stromal cells) from healthy bone marrow donors.
- Trial name
- NCT01463475
- Testing
- Bone marrow aspirate
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison