Clinical trials: Bronchiectasis Adult
Chronic Obstructive Pulmonary Disease, Bronchiectasis
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
Background: Some health conditions make breathing difficult and uncomfortable. When this happens every day, it is called chronic breathlessness.
- Conditions
- Chronic Obstructive Pulmonary Disease, Bronchiectasis, Interstitial Lung Disease, Lung Cancer
- Trial name
- SELF-BREATHE (NCT06326957)
- Testing
- SELF-BREATHE
- Where
- United Kingdom
- Volunteers
- 246 people
- Sponsor
- King's College Hospital NHS Trust
Bronchiectasis
Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis
The AIR-BX1 study enrolled people with non-cystic fibrosis (non-CF) bronchiectasis and gram-negative airway infection. Participants received two 28-day courses of either Aztreonam for Inhalation Solution (AZLI) or placebo taken 3…
- Trial name
- AIR-BX1 (NCT01313624)
- Testing
- AZLI
- Where
- 60 sites in United States, Australia and 1 more
- Volunteers
- 266 people
- Sponsor
- Gilead Sciences
Bronchiectasis Adult
Predictors of Physical Activity Performance and Dynamic Hyperinflation in Patients With Bronchiectasis
Bronchiectasis is characterized by abnormal and irreversible airway dilation and can be caused by a wide variety of diseases, including congenital diseases, mechanical bronchial obstruction, respiratory infections, and…
- Trial name
- NCT04234789
- Testing
- cardiopulmonary exercise testing with dynamic hyperinflation maneuver, spirometry, pletysmography
- Where
- Brazil
- Volunteers
- 208 people
- Sponsor
- University of Sao Paulo General Hospital
Bronchiectasis Adult
Home Airway Clearance in Patients With Bronchiectasis (Home-Care Bronchiectasis)
Bronchiectasis is a chronic multiple etiologies pulmonary disease characterized by permanent dilatation of the caliber of the bronchial tree territory with an alteration of mucociliary clearance.
- Trial name
- NCT04742270
- Testing
- SIMEOX+ respiratory physiotherapy telecare
- Where
- 3 sites in France
- Volunteers
- 22 people
- Sponsor
- Physio-Assist
Bronchiectasis with Acute Exacerbation
Value of Bronchoalveolar Lavage with Acetylcysteine in the Treatment of Bronchiectasis.
Bronchiectasis is a clinical syndrome characterised by chronic cough, profuse sputum and/or intermittent haemoptysis, with or without shortness of breath and respiratory failure of varying severity, and abnormal thickening and…
- Trial name
- NCT06726356
- Testing
- Bronchoalveolar Lavage
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Bronchiectasis Adult
Respiratory Physiotherapy for Patients With Bronchiectasis
Study design: observational, retrospective Population: 270 patients diagnosed with bronchiectasis (BX) treated at the Respiratory Physiotherapy Unit of the Rehabilitation Service of the A Coruña and Cee Health Area.
- Trial name
- PhysioBX (NCT07733323)
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- Yolanda Sanesteban Hermida
Bronchiectasis Adult
A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong
Bronchiectasis is associated with repeated exacerbations which occurs at rates of 1.5-6.5 per patients per year, and are associated with an increased risk of admission and readmission to hospital, and high health care costs.
- Trial name
- NCT04538859
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- Chinese University of Hong Kong
Bronchiectasis Adult
Effect of AIRVO Heated Humidification in Bronchiectasis
The aim of the study is to investigate whether long-term heated humidification therapy (AIRVO) administrated for 1 year over-night on top of standard therapy can reduce the number of exacerbations in adults with non-cystic…
- Trial name
- AIRVO-BX (NCT04102774)
- Testing
- Over-night treatment with myAIRVO2
- Where
- 21 sites in Italy
- Volunteers
- 130 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bronchiectasis Adult, Mediastinal Lymphadenopathy
Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound
The purpose of this study is to assess if there is decrease in cough during flexible bronchoscopy and endobronchial ultrasound when different modes of lidocaine administration are used.
- Conditions
- Bronchiectasis Adult, Mediastinal Lymphadenopathy, Pneumonia, Chest--Diseases
- Trial name
- NCT03829618
- Testing
- Topical lidocaine, Nebuliser solution, Nebuliser Suspension
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Respiratory Virus Infection, Stroke
Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications
Respiratory virus infections are one of the major causes of hospitalizations, and outbreaks of respiratory virus infection have led to severe economic loss.
- Conditions
- Respiratory Virus Infection, Stroke, Lung Disease, Acute Coronary Syndrome
- Trial name
- NCT03816059
- Testing
- Respiratory virus testing
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Bronchiectasis Adult
Efficacy and Safety of An'Ningpai Expectorant in Non-CF Bronchiectasis
The objective of this study was to assess whether the long-term use of oral An'Ningpai Enteric Soft Capsuleson (300 mg, three times daily, 12 months) might reduce the incidence of exacerbations and improve the quality of life in…
- Trial name
- NCT04511897
- Testing
- An'ningpai
- Volunteers
- 200 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Chronic Bronchiectasis, Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety Study of a Percussion Device to Mobilise Sputum From Respiratory Passage
A Malaysian company by name Formedic Technologies SDN BHD has devised a hand held machine which is supposed to mimic the chest percussion performed by professional physiotherapist to mobilize sputum through the respiratory…
- Trial name
- LEGA (NCT01480882)
- Testing
- Conventional Chest Physiotherapy (CCPT), Mechanical percussion (LEGA)
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- Penang Hospital, Malaysia
Bronchiectasis Adult
Value of Inhaled Treatment With Aztreonam Lysine in Bronchiectasis
A randomised controlled trial of the safety, tolerability and effectiveness of Cayston Cayston (Aztreonam Lysine) compared to placebo in participants with bronchiectasis.
- Trial name
- VitalBE (NCT03696290)
- Testing
- Aztreonam lysine
- Where
- 14 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Dundee
Primary Ciliary Dyskinesia, Primary Immune Deficiency
Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults
The investigators will utilize a systematic approach for the diagnostic evaluation of patients to identify characteristics which may distinguish between Primary Immunodeficiency (PID) disorders versus Primary Ciliary Dyskinesia…
- Conditions
- Primary Ciliary Dyskinesia, Primary Immune Deficiency, Kartagener Syndrome
- Trial name
- NCT04702243
- Testing
- Genetic Testing for PCD or PID, Unaffected Family Member Genetic Testing
- Where
- 8 sites in United States, Canada
- Volunteers
- 436 people
- Sponsor
- University of North Carolina, Chapel Hill
Bronchiectasis Adult
The Role of Airway Microbiota on Clinical Phenotypes and Disease Severity in Bronchiectasis
Bronchiectasis is characterized pathologically by permanent bronchial dilatation and airway inflammation. The pathogenesis of the disease and the inflammatory, infective and molecular drivers of disease progression are not fully…
- Trial name
- NCT05068518
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 270 people
- Sponsor
- Chang Gung Memorial Hospital
Respiratory Tract Diseases, Abnormal Mucus Secretions
A Clinical Trial to Compare the Efficacy and Safety of 1-week Treatment of Intravenous N-acetylcysteine (NAC) 600 mg Twice Daily, Ambroxol Hydrochloride 30 mg Twice Daily and Placebo as Expectorant Therapies in Adult Chinese Patients With Respiratory Tract Diseases and Abnormal Mucus Secretions
This is a phase 3, multicenter, randomized, rater- and patient-blind, placebo- and active-controlled, 3-arm parallel group clinical trial.
- Trial name
- NCT03843541
- Testing
- N-acetylcysteine (NAC) 600 mg, Ambroxol hydrochloride 30 mg
- Where
- 32 sites in China
- Volunteers
- 333 people
- Sponsor
- Zambon SpA
Bronchiectasis Adult, Radiomics
Multicenter Cohort Study on Predicting Bronchiectasis Progression, Complications, and Prognosis Using Multi-omics
Bronchiectasis is a heterogeneous condition with diverse etiologies and clinical manifestations. Its progression involves a vicious cycle of airway inflammation, recurrent infection, and structural damage, leading to persistent…
- Trial name
- NCT07263373
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Mycobacterium Avium Intracellulare Complex (MAC)
Mycobacterium Avium Intracellulare Complex (MAC) Study
This study is short course (3 month) multiple drug antibiotic therapy. The purpose of this research study is to evaluate the clinical and radiology response to assess whether drug resistance develops and assess quality of life…
- Trial name
- MAC (NCT00826423)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Bronchiectasis Adult
Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil Function
Double-blind, randomized, cross-over trial involving 20 participants with bronchiectasis. This trial will make an important contribution to therapeutic development in bronchiectasis by determining whether alpha-1 antitrypsin…
- Trial name
- BATMAN (NCT05582798)
- Testing
- Alpha 1-Proteinase Inhibitor 180mg/kg, Alpha 1-Proteinase Inhibitor 120mg/kg, Sodium chloride
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Dundee
Bronchiectasis Adult
Investigating the Clinical Features and Prognosis of Bronchiectasis Adult Patients
Bronchiectasis is a chronic respiratory disease characterized by permanent bronchiectasis.The incidence and prevalence of bronchiectasis have assumed continuously grows in global.
- Trial name
- NCT04987827
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,250 people
- Sponsor
- Ruijin Hospital