Clinical trials: Breathlessness
Cardiovascular Diseases, Medical Device
Validation of PMcardio AI-assisted Clinical Assistant in Primary Care
This study aimed to analyze and investigate whether the use of the PMcardio clinical assistant leads to a more efficient patient management in primary care and more accessible specialised care compared to usual standards of care…
- Conditions
- Cardiovascular Diseases, Medical Device, Primary Health Care, Electrocardiogram
- Trial name
- PMCARDIO-PT1 (NCT05329246)
- Testing
- AI-assisted Clinical Assistant PMcardio
- Where
- 56 sites in Slovakia
- Volunteers
- 836 people
- Sponsor
- Powerful Medical
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest
This study is meant to compare the amount of oxygen required for hypoxemia relief between current standard of care (oxygen only) and oxygen with the addition of high flow air for Chronic Obstructive Pulmonary Disease (COPD)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial, Pulmonary Fibrosis, Hypoxemia
- Trial name
- NCT04170062
- Testing
- Nasal Delivery of High-Flow Air and Oxygen Therapy, Nasal Delivery of Oxygen Therapy
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins University
Asthma, Pneumonia
PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress
This study will investigate the efficacy of a novel air purification technology, Photo Electrochemical Oxidation (PECO), has on pediatric patients hospitalized for respiratory distress.
- Conditions
- Asthma, Pneumonia, Respiratory Distress Syndrome
- Trial name
- NCT03647397
- Testing
- Photo Electrochemical Oxidation (PECO) for Air Purification
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Molekule
Coma, Major Trauma
Succinylcholine vs Rocuronium for Prehospital Emergency Intubation
All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included in order to compare the use of succinylcholine vs Rocuronium for prehospital emergency…
- Conditions
- Coma, Major Trauma, Respiratory Distress, Shock
- Trial name
- CURASMUR (NCT02000674)
- Testing
- Succinylcholine : 1mg/kg, Rocuronium : 1.2 mg/kg
- Where
- 17 sites in France
- Volunteers
- 1,321 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Pulmonary Arterial Hypertension
Feasibility of Slow-paced Respiration Therapy for Treatment of a Symptom Cluster in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a chronic illness characterized by increased pulmonary pressures resulting in right heart failure and premature death.
- Trial name
- NCT02080533
- Testing
- Slow-paced respiration therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Dyspnea
Evaluation of Transient Dyspnea During Gadoxetic Acid Enhanced Multiphasic Liver MRI
The purpose of this study is to observe transient dyspnea pattern after Gd-EOB-DTPA administration by obtaining continuous dynamic T1 weighted image data.
- Trial name
- NCT02395991
- Testing
- gadoxetic acid, Magnetic resonance imaging (MRI)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Dyspnea and Respiratory Insufficiency in Children
Multidimensional Characterization of Dyspnea in Children
There is no specific tool existing to describe dyspnea in children in a multidimensional way. It has been shown in adult studies that multidimensional dyspnea evaluation scales are well correlated to quality of life and…
- Trial name
- DYSPED (NCT05500833)
- Testing
- Multidimentional observation scale (MDP)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Neoplasm Malignant
Resistance Inspiratory Muscle Training for Patients With Thoracic Malignancies
A small-scale pilot randomized controlled trial conducted by the investigators demonstrated some preliminary evidence that inspiratory muscle training (IMT) could be a promising self-management method for alleviating…
- Trial name
- NCT03834116
- Testing
- Inspiratory muscle training
- Where
- China
- Volunteers
- 196 people
- Sponsor
- The Hong Kong Polytechnic University
Pneumonia, Pulmonary Edema
Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath
This is a pilot observational feasibility study of the ability of paramedics to assess thoracic ultrasound findings in the prehospital environment.
- Conditions
- Pneumonia, Pulmonary Edema, Dyspnea
- Trial name
- NCT02638649
- Testing
- Lung ultrasound, ultrasound
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Yale University
Asthma
Crossover Study to Evaluate the Efficacy, Safety and Tolerability of Different Doses of Indacaterol in Patients With Persistent Asthma
The purpose of this study is to determine the efficacy of indacaterol 55µg once daily (and 27.5 µg twice) in QVA149 compared to 75 µg indacaterol monotherapy.
- Trial name
- QAB149 (NCT01959412)
- Testing
- Indacaterol 27.5 mcg, Indacaterol 37.5, Indacaterol 55 mcg
- Where
- 12 sites in United States
- Volunteers
- 91 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease
Tolerance of Surgical Masks in Chronic Respiratory Diseases
The study is conducted in the context of the COVID-19 pandemic in general, and more specifically in the context of the evaluation of the use of protective masks as a barrier to the spread of the virus.
- Trial name
- TOLMASK (NCT05454631)
- Testing
- surgical mask (5 different types)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Idiopathic Pulmonary Fibrosis, Cough
Does CBT Improve the Perception/Impact of Cough and Breathlessness in IPF Patients
Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease of unknown cause for which there is no effective medical treatment.
- Conditions
- Idiopathic Pulmonary Fibrosis, Cough, Breathlessness
- Trial name
- NCT01738711
- Testing
- Cognitive behavioural therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Victoria Infirmary
Interstitial Lung Disease
The Impact of Pulmonary Rehabilitation in Interstitial Lung Disease
The purpose of this study is to determine if pulmonary rehabilitation has any effect on breathlessness, quality of life, physical function and depression in persons with interstitial lung disease.
- Trial name
- PR-ILD (NCT01055730)
- Testing
- Pulmonary rehabilitation
- Where
- 6 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- University of California, San Francisco
Acute Myocardial Infarction, Heart Failure
SHORTness of Breath In the Emergency Department (SHORTIE)
SHORTIE is a two-phase study to determine the impact of the Triage Profiler S.O.B. (Shortness Of Breath) Panel on patient management, outcome, and cost.
- Conditions
- Acute Myocardial Infarction, Heart Failure, Pulmonary Embolism
- Trial name
- NCT00206830
- Testing
- Triage Profiler S.O.B. Panel
- Where
- 5 sites in United States
- Volunteers
- 306 people
- Sponsor
- Abbott RDx Cardiometabolic
COPD Exacerbation, CHF
Evaluation of the Multidimensional Dyspnea Profile (MDP)
Aim of this multicenter prospective cohort study is the evaluation of the multidimensional qualities of dyspnea in a number of diseases using the Multidimensional Dyspnea Profile (Banzett et al, ERJ 2015).
- Conditions
- COPD Exacerbation, CHF, OSA, COPD
- Trial name
- NCT04090671
- Testing
- Multidimensional Dyspnea Profile
- Where
- 4 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Alpha 1-antitrypsin Deficiency (AATD)
Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction
Brief Summary: This study aims to find out if a genetic condition called Alpha-1 Antitrypsin Deficiency (AATD) is more common in people who have shortness of breath and signs of airway obstruction on their breathing tests.
- Trial name
- AATD-SAO (NCT07152834)
- Testing
- Blood Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 734 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Cystic Fibrosis
HFN Versus NIV in Cystic Fibrosis. The HIFEN Study
Many patients with cystic fibrosis (CF) require hospitalization and/or Intensive Care Unit (ICU) admission because of acute exacerbation of chronic respiratory failure or for any acute deterioration of clinical status.
- Trial name
- NCT02262871
- Testing
- High flow nasal oxygen cannula, Noninvasive ventilation
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
COVID-19 Pandemic, Dyspnea; Cardiac
Covid-19 Infection and Long-term Cardiovascular Symptoms
From the registry of professor Kojuri clinic , those with Covid-19 infection were selected and was contacted and asked about the cardiovascular symptoms, 1 year after the covid infection
- Conditions
- COVID-19 Pandemic, Dyspnea; Cardiac, Chest Syndrome, Functional Cardiac Disorder
- Trial name
- NCT05715879
- Testing
- covid infection, admission to hispital
- Where
- Iran
- Volunteers
- 879 people
- Sponsor
- Shiraz University of Medical Sciences
Diaphragmatic Dysfunction
Comparative Ultrasonic Study of Post Operative Diaphragmatic Dysfunction in Abdominal and Head and Neck Surgery
Diaphragmatic dysfunction (DD) is one of the main risk factors for post operative respiratory distress syndrome. Ultrasonography is a diagnosis tool for DD but few studies have been published.
- Trial name
- Under the Dome (NCT01737775)
- Testing
- Diaphragmatic amplitude measurement
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Pleural Effusion, Dyspnea
Thoracentesis: Symptoms and Prediction of the Need for Therapeutic Thoracentesis
Recurrent fluid surrounding the lungs is associated with poor quality of life, the main symptom being dyspnea. These patients are in need of recurrent removal of the fluid using drainage.
- Conditions
- Pleural Effusion, Dyspnea, Patient Reported Outcomes, Diaphragm Movement
- Trial name
- NCT04236934
- Testing
- Assesment of diaphragm shape and diaphragm movement (by M-mode and the AREA-method) by ultrasound before and after thoracentesis
- Where
- 2 sites in Denmark
- Volunteers
- 107 people
- Sponsor
- Naestved Hospital