Clinical trials: Breast-Conserving Surgery
Breast Cancer
Late Toxicity in Breast Cancer Patients Treated With Breast-conserving Surgical Procedures and Radiotherapy Using the Simultaneous Integrated Boost Technique
In summary, breast conserving therapy (BCT) is an effective, save and widely used treatment technique for early breast cancer. Radiotherapy has shown to give better local control and survival benefit and is an integrated part of…
- Trial name
- FUSIB (NCT02505906)
- Testing
- Simultaneous Integrated Boost Technique
- Where
- Netherlands
- Volunteers
- 5,043 people
- Sponsor
- University Medical Center Groningen
Breast Neoplasm
Randomized Study of Elective Regional Lymph Node Irradiation in N1 Breast Cancer
This study evaluates the impact of elective regional lymph node irradiation on N1 breast cancer patients receiving post-lumpectomy radiotherapy and anthracycline plus taxane (AT)-based chemotherapy.
- Trial name
- NCT03269981
- Testing
- Whole breast irradiation, Whole breast and nodal irradiation
- Where
- South Korea
- Volunteers
- 827 people
- Sponsor
- Samsung Medical Center
Breast Cancer
Hypofractionated Vs Conventional Fractionated Radiotherapy After Breast Conserving Surgery
The study was designed to investigate whether hypofractionated radiotherapy(HF-RT) is noninferior to conventionally fractionated radiotherapy (CF-RT) in terms of tumor loco-regional control for patients after breast conserving…
- Trial name
- NCT04025164
- Testing
- Hypofractionated Radiotherapy, Conventional fractionated Radiotherapy
- Where
- 5 sites in China
- Volunteers
- 4,052 people
- Sponsor
- Fudan University
Pain Score, Pain Postoperative
Pain Sensitivity Questionnaire Applied in Preoperative Period in Lumpectomy
Objective: The Pain Sensitivity Questionnaire (PSQ) is a clinically valuable tool that has been shown to correlate with various experimental pain sensitivity assessments in healthy individuals and patients with chronic pain.
- Trial name
- Lumpectomy (NCT06928064)
- Testing
- Prediction of Postoperative Pain Severity Using Pain Sensitivity Questionnaire Applied in Preoperative Period in Patients Undergoing Breast-Conserving Surgery (Lumpectomy).
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Breast Cancer, Cancer of Breast
Shave Margins in Breast Conservation Therapy
The investigators propose a randomized controlled superiority trial of standard breast-conserving surgery (BCS) versus BCS with cavity shave margins (CSM).
- Conditions
- Breast Cancer, Cancer of Breast, Cancer of the Breast
- Trial name
- SMART (NCT02462200)
- Testing
- Breast-conserving surgery (BCS), Cavity shave margins (CSM), BREAST-Q Questionnaire
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
Breast-Conserving Surgery and Radiation Therapy in Patients With Multiple Ipsilateral Breast Cancer
RATIONALE: Breast-conserving surgery is a less invasive type of surgery for breast cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x rays to kill tumor cells.
- Trial name
- NCT01556243
- Testing
- therapeutic conventional surgery, whole breast irradiation
- Where
- 350 sites in United States
- Volunteers
- 270 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Neoplasms, Heart Injuries
Prospective Assessment of Radiation-induced Heart Injury in Left-sided Breast Cancer
This study is to prospectively investigate the cardiac dose-sparing effect and clinical benefit of deep inspiration breath-hold (DIBH) technique.
- Conditions
- Breast Neoplasms, Heart Injuries, Radiation Toxicity
- Trial name
- NCT03461588
- Testing
- free-breathing, deep inspiratory breath-holding
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Shu lian Wang
Breast Cancer Female
Validation of Prone Crawl Radiotherapy for Whole-breast Irradiation After Breast Conserving Surgery
The aim of this study is to validate the obtained results of setup precision, comfort and setup time. The possibility of using breath hold for heart sparing in combination with prone crawl position will be tested.
- Trial name
- NCT05179161
- Testing
- Prone crawl positioning
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Breast Cancer Invasive
A Phase II Clinical Trial of Artificial Intelligence-assisted One-stop Radiotherapy for Breast Cancer After Breast-conserving Surgery
Background: Breast cancer became the most prevalent cancer globally in 2020, and post-surgery radiotherapy is crucial for most patients. Traditional radiotherapy is complex and time-consuming, affecting patient experience.
- Trial name
- BC-AIO (NCT06686459)
- Testing
- ALL-in-one radiotherapy, IMRT
- Where
- China
- Volunteers
- 860 people
- Sponsor
- Sun Yat-sen University
Breast Cancer
Retrospective Evaluation of Ultrasound-assisted Tumor Surgery in Breast-conserving Therapy
The aim of this study is to evaluate whether standardizing intraoperative ultrasound (IOUS) with the "Tübingen Ultrasound Ruler" reduces R1 resection rates in breast-conserving surgery.
- Trial name
- MAC004 (NCT07519668)
- Where
- Germany
- Volunteers
- 273 people
- Sponsor
- University Hospital Tuebingen
Breast Neoplasm, Cosmetic Outcome
Aspects of Breast-conserving Surgery
Prospective study of cosmetic outcome and quality of life for women undergoing breast cancer surgery using patient a reported outcome measure (BREAST-Q) and a computer program validated to assess cosmetic outcomes after breast…
- Conditions
- Breast Neoplasm, Cosmetic Outcome, Quality of Life
- Trial name
- NCT04227613
- Where
- Sweden
- Volunteers
- 351 people
- Sponsor
- Lund University
Ductal Carcinoma In Situ, DCIS
Omission of Adjuvant Radiotherapy in Low- and Intermediate-Risk Ductal Carcinoma In Situ After Breast-Conserving Surgery
This is a prospective, multicenter, randomized, open-label, phase III non-inferiority trial designed to evaluate whether omission of postoperative radiotherapy is clinically acceptable in patients with low- and intermediate-risk…
- Trial name
- NCT07762885
- Testing
- Adjuvant Radiotherapy, tamoxifen
- Where
- China
- Volunteers
- 636 people
- Sponsor
- Fudan University
Carcinoma Breast
Ten Years Results of a Score System to Address Adjuvant Therapies After Breast Conserving Surgery for Ductal Carcinoma in Situ of the Breast
By this non-randomized prospective study, it's evaluated the outcome of patients underwent BCS for DCIS at whom an established score system to address adjuvant therapies have been prospectively applied, according to the wideness…
- Trial name
- DCIS (NCT03002766)
- Testing
- Breast conservative surgery
- Where
- Italy
- Volunteers
- 224 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer and Rehabilitation
The Effect of Manual Lymph Drainage in the Treatment of Breast Edema
Breast conserving surgery (BCS) is widely used in the treatment of breast cancer. Breast edema can be seen frequently after BCS and radiotherapy applications.
- Trial name
- NCT05240235
- Testing
- Education, compression and exercise therapy, Education, compression and exercise therapy manual lymph drainage
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Acibadem University
Breast Cancer
APBI: 27Gy in 5 Fractions for Early Breast Cancer
This study will test the safety of partial breast RT using 27Gy in 5 daily fractions which is expected to be equally tolerated as standard whole breast irradiation (WBI) based on radiobiologic modeling of the fibrosis response of…
- Trial name
- ACCEL (NCT02681107)
- Testing
- APBI 27Gy in 5 fractions
- Where
- Canada
- Volunteers
- 274 people
- Sponsor
- AHS Cancer Control Alberta
Breast Cancer
Percutaneous Removal and Margin Ablation for Breast Cancer
We hypothesize that radiofrequency ablation after single-insertion image guided vacuum assisted biopsy (IVEB) can be used to achieve negative margins in small unicentric breast cancers (≤1.5 cm).
- Trial name
- NCT00574301
- Testing
- Percutaneous Removal and Margin Ablation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Breast Cancer, Sentinel Lymph Node
Prospective Feasibility Study Applying the ACOSOG Z0011 Criteria to Chinese Patients
In patients undergoing breast-conserving surgery and having positive sentinel lymph nodes (SLNs), the ACOSOG Z0011 trial showed equivalent overall survival(OS) and disease-free survival(DFS) outcomes for patients receiving SLN…
- Conditions
- Breast Cancer, Sentinel Lymph Node, Local Recurrence of Malignant Tumor of Breast
- Trial name
- NCT03606616
- Testing
- no further ALND arm
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Peking University People's Hospital
Breast Cancer
Observation of the Effect of Preoperative Use of Dexmedetomidine Hydrochloride Nasal Spray on Optimizing Awake Sedation During Breast-Conserving Surgery for Breast Cancer and Postoperative Awake Status
This clinical trial aims to evaluate the efficacy and safety of Dexmedetomidine Hydrochloride Nasal Spray for conscious sedation and anxiety relief during breast-conserving surgery.
- Trial name
- NCT07350928
- Testing
- Induction of anesthesia with dexmedetomidine nasal spray prior to surgery
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Breast Cancer
Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer?
All patients undergoing breast cancer surgery are left with scars which can significantly affect their physical and psychological well being.
- Trial name
- NCT00175344
- Testing
- Scar massage.
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of British Columbia
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Manual Lymphatic Drainage Breast Massage in Breast Cancer Patients After Breast Conserving Surgery
This phase II trial evaluates manual lymphatic drainage breast massage for reducing treatment-related side effects in women undergoing radiation therapy after breast conserving surgery for breast cancer that has not spread to…
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Localized Breast Carcinoma
- Trial name
- NCT06297265
- Testing
- Lymphedema Management, Questionnaire Administration, Adjuvant breast radiation therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern California