Clinical trials: Breast Tumors
Breast Cancer
Dual Anti-HER2 Therapy (Lapatinib and Trastuzumab) Plus Chemotherapy in HER2-positive MBC
To explore the real world situation of trastuzumab and lapatinib combined chemotherapy in China, and to explore the relationship between progression free survival and treatment.
- Trial name
- NCT04001634
- Where
- China
- Volunteers
- 285 people
- Sponsor
- Fudan University
Irradiation; Adverse Effect, Irradiation Hypothyroidism
Evaluation of Hypothyroidism Incidence After Breast Cancer Supraclavicular Irradiation
Prospective, multicentric, comparative, non randomised, in current care. Primary objective: To evaluate the incidence of hypothyroidism in breast cancer patients treated by radiotherapy including the supra-clavicular area over a…
- Trial name
- EPITHERM (NCT02824016)
- Testing
- biological sample, supraclavicular irradiation
- Where
- 3 sites in France
- Volunteers
- 500 people
- Sponsor
- Institut Jean-Godinot
Breast Cancer, Kidney Neoplasms
Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging
This is a 4-arm, single-center study involving 40 participants. Ten healthy volunteers will be enrolled for system imaging optimization, and thirty (30) patients with previously identified lesions in the breast, liver, or…
- Conditions
- Breast Cancer, Kidney Neoplasms, Liver Neoplasms
- Trial name
- NCT07225114
- Testing
- contrast agent perflutren lipid, Ultrasound Imaging
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
HER2-positive Breast Cancer, Biosimilar
HER2-directed Biosimilar in Breast Cancer: Real World ePRO
This project will engage anti-HER2 directed Trastuzumab biosimilar with a novel quality of ePRO and enable comparison of reliable reference real world patient data, thereby creating a basis for analytic research in order to…
- Conditions
- HER2-positive Breast Cancer, Biosimilar, Patient Reported Outcome
- Trial name
- OGIPRO (NCT05234021)
- Where
- 3 sites in Switzerland
- Volunteers
- 52 people
- Sponsor
- OnkoZentrum Zürich AG
Advanced Cancer, Ovarian Cancer
COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.
This is a Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary clinical activity of COM701 as monotherapy and in combination with nivolumab.
- Conditions
- Advanced Cancer, Ovarian Cancer, Breast Cancer, Lung Cancer
- Trial name
- NCT03667716
- Testing
- COM701, COM701 with Opdivo (Nivolumab).
- Where
- 11 sites in United States
- Volunteers
- 121 people
- Sponsor
- Compugen Ltd
Breast Cancer Female
Investigating the Potential Role of a Novel Quadrate Combination Therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic Acid and Cannabidiol ( Selective Cyp 26 Inhibitor) for Treating Early Breast Cancer.
Investigating the potential role of a novel quadrate combination therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic acid and Cannabidiol ( selective cyp 26 inhibitor) for treating early breast cancer.
- Trial name
- NCT05016349
- Testing
- All trans-retinoic acid, 13-Cis Retinoic Acid plus Tocopherol, Mifepristone
- Volunteers
- 160 people
- Sponsor
- Mahmoud Ramadan mohamed Elkazzaz
Solid Tumor
A Study of BDTX-189, an Orally Available Allosteric ErbB Inhibitor, in Patients With Advanced Solid Tumors.
This was a clinical study with an orally administered drug, BDTX-189 in participants with advanced solid tumors that had select mutations or alterations in human epidermal growth factor receptor 2 (HER2/ErbB2) genes or epidermal…
- Trial name
- MasterKey-01 (NCT04209465)
- Testing
- BDTX-189
- Where
- 38 sites in United States, Denmark and 2 more
- Volunteers
- 91 people
- Sponsor
- Black Diamond Therapeutics, Inc.
Breast Cancer
A Home-based Physical Activity Intervention in Breast Cancer Survivors
The aim of this current study was to investigate the effects of a pragmatic home-based physical activity programme on primarily physical activity levels and secondarily weight maintenance, health-related quality of life (HRQoL)…
- Trial name
- PHAB (NCT02408107)
- Testing
- Physical activity
- Volunteers
- 80 people
- Sponsor
- Dudley Group NHS Foundation Trust
Breast Cancer, Peripheral Neuropathy
Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients
Aim of the work This study aims to evaluate the possible beneficial role of silymarin in attenuating both doxorubicin related cardiac and hepatic toxicities and paclitaxel associated peripheral neuropathy and improving cognitive…
- Conditions
- Breast Cancer, Peripheral Neuropathy, Cardiac Toxicities, Hepatic Toxicity
- Trial name
- NCT05595109
- Testing
- Silymarin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Tanta University
Breast Neoplasm
Preventing Chemotherapy-induced Peripheral Neuropathy Using PRESIONA Exercise Program
The aim of this study is to determinate if therapeutic exercise with blood flow restriction (BFR) during neoadjuvant chemotherapy potentialy neurotoxic could prevent the onset of chemotherapy induced peripheral neuropathy (CIPN)…
- Trial name
- PRESIONA (NCT04652609)
- Testing
- PRESIONA
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidad de Granada
Breast Cancer, Breast Cancer Surgery
Pre-Surgery Positron Emission Mammography in Patients With Newly Diagnosed Breast Cancer
The purpose of the study is to determine the optimal, lowest dose of radioactive tracer required for Positron Emission Mammography (PEM), and the accuracy and reliability of PEM in pre-surgical evaluations for patients with newly…
- Trial name
- NCT01241721
- Testing
- Positron Emission Mammography (PEM)
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Swedish Medical Center
Breast Cancer
Preoperative Accelerated Partial Breast Irradiation in Patients With Locally Recurrent or Second Primary Breast Cancer
This study evaluates the acute toxicity and feasibility of repeat breast conserving therapy with preoperative accelerated partial breast re-irradiation (PAPBI) in female patients aged 51 years or older with ipsilateral recurrent…
- Trial name
- PAPBI-3 (NCT06362616)
- Testing
- Preoperative accelerated partial breast irradiation, Breast conserving surgery, Sentinel node procedure
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
The Diagnosis and Prognosis of Nonpalpable Breast Cancer Detected by the US vs Mammography: a Clinical Noninferiority Trial.
To evaluate and compare the sensitivity, specificity, AUC, pathology results of core needle biopsy and surgical pathology results coincidence rate, tumor staging, and DFS (disease-free survival) of US-detected nonpalpable breast…
- Trial name
- NCT04360616
- Testing
- imaging
- Where
- China
- Volunteers
- 1,277 people
- Sponsor
- The First Affiliated Hospital of the Fourth Military Medical University
Breast Cancer
A Study to Determine Biopsy Rate in Participants With a First Relapse of Breast Cancer
This is a retrospective, and observational cohort study to determine the proportion of breast cancer first relapses, that are biopsied. The duration of the study will be approximately 24 months.
- Trial name
- NCT02761616
- Testing
- eBC treated participants
- Where
- 4 sites in Argentina
- Volunteers
- 76 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer, Chemotherapy
Effects of an Integrative Day-care Clinic Program for Breast Cancer Patients During Chemotherapy
The aim of the study was to evaluate a new integrative day-care clinic concept for breast cancer patients receiving chemotherapy. This is an explorative pilot study. Therefore, all outcomes are analyzed exploratively.
- Conditions
- Breast Cancer, Chemotherapy, Mind-Body-Medicine, Acupuncture
- Trial name
- NCT03868865
- Testing
- Integrative mind-body-medicine group program
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Universität Duisburg-Essen
Breast Cancer
Radiation Therapy in Women With Low Risk Early-Stage Breast Cancer Who Have Undergone Breast Conservation Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.
- Trial name
- IMPORT (NCT00814567)
- Testing
- radiation therapy
- Where
- United Kingdom
- Volunteers
- 2,018 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Breast Cancer, Breast Cyst
Pilot Clinical Study on a Low-power Electromagnetic Wave Breast Imaging Device for Cancer Screening Purposes.
The trialed investigational medical imaging device is a low-power microwave breast imaging system for cancer screening purposes. It is an active device which uses non-ionizing radiation.
- Trial name
- NCT03475992
- Testing
- Low-power microwave breast imaging system
- Where
- Ireland
- Volunteers
- 25 people
- Sponsor
- MVG Industries SAS
Triple Negative Breast Cancer (TNBC)
A Nurse-Led, Coping and Supportive Intervention for Patients With Triple-Negative Breast Cancer
The purpose of this study is to explore the feasibility and acceptability of a nurse-led, coping, and supportive care intervention for patients with triple-negative breast cancer.
- Trial name
- RESTORE (NCT07513311)
- Testing
- RESTORE, Enhanced Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Fulvestrant or Tamoxifen in Treating Postmenopausal Women Who Are Undergoing Surgery for Ductal Carcinoma in Situ of the Breast
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using fulvestrant or tamoxifen may fight breast cancer by blocking the use of estrogen by the tumor cells.
- Trial name
- NCT00126464
- Testing
- fulvestrant, tamoxifen citrate, conventional surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ
Hormone Therapy Or Chemotherapy Before Surgery Based on Gene Expression Analysis in Treating Patients With Breast Cancer
This randomized pilot clinical trial studied whether the Oncotype DX gene expression "Recurrence Score" (RS) would be useful for helping make a decision about which type of pre-operative treatment, hormone therapy or chemotherapy…
- Conditions
- Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ, Stage II Breast Cancer, Stage IIA Breast Cancer
- Trial name
- NCT01293032
- Testing
- Neoadjuvant Therapy, Therapeutic Conventional Surgery, Laboratory Biomarker Analysis
- Where
- 8 sites in United States, Canada
- Volunteers
- 59 people
- Sponsor
- Virginia Commonwealth University
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