Clinical trials: Breast Cancer Diagnosis
Breast Neoplasms
Targeting the Hippo Transducer TAZ in Breast Cancer With Statins
This pre-surgical, window-of-opportunity study is designed to investigate whether atorvastatin reduces the proliferation marker Ki-67 via modulation of the Hippo transducer TAZ.
- Trial name
- TRINACRIA (NCT02416427)
- Testing
- Atorvastatin
- Volunteers
- 78 people
- Sponsor
- Regina Elena Cancer Institute
Breast Carcinoma, Cancer Survivor
Support Group Program in Improving Quality of Life in Underserved Urban Latina Breast Cancer Survivors
This randomized clinical trial studies a support group program in improving quality of life in underserved urban Latina breast cancer survivors.
- Trial name
- NCT02521961
- Testing
- Informational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Fred Hutchinson Cancer Center
Breast Neoplasms
Phase 2 Study of Adjuvant Radiotherapy in Breast Cancer Using a Once a Week Hypofractionated Regimen
The implementation of a weekly hypofractionated radiation could be an advantageous alternative. The convenience of less treatment days could cause a greater adherence, decrease of costs and increase the offer of radiotherapy to…
- Trial name
- NCT01965483
- Testing
- once-weekly breast irradiation
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Instituto do Cancer do Ceara
Leptomeningeal Metastasis of HER2-positive Breast Cancer
Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Trastuzumab in Breast Cancer With Leptomeningeal Metastasis
Evaluate the efficacy and safety of Intrathecal Administration of Thiotepa in Combination with Trastuzumab via the Ommaya Reservoir in Breast Cancer with Leptomeningeal Metastasis
- Trial name
- NCT07263425
- Testing
- Intrathecal Administration of Thiotepa in Combination with Trastuzumab via the Ommaya Reservoir
- Where
- China
- Volunteers
- 26 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Breast Cancer
Skeletal Events of Hormonal Treatment and Radiotherapy in Patient With Breast Cacer
study of lymphedema and skeletal events in breast cacer patient receiving adjuvant hormonal therapy and radiothearpy
- Trial name
- NCT04792840
- Testing
- Femara Pill
- Volunteers
- 100 people
- Sponsor
- Assiut University
Fallopian Tube, Primary Peritoneal Cancer
Study of ABT-767 in Subjects With Breast Cancer 1 and Breast Cancer 2 (BRCA 1 and BRCA 2) Mutations and Solid Tumors or High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This is a Phase 1, dose escalation trial evaluating the tolerability, pharmacokinetics, and pharmacodynamics of ABT-767 in subjects with advanced Breast Cancer 1 or 2 gene (BRCA1 or BRCA2)-mutated solid tumors and high grade…
- Conditions
- Fallopian Tube, Primary Peritoneal Cancer, Solid Tumors (e.g. Breast, Ovarian, Prostate, or Pancreatic) and Ovarian
- Trial name
- NCT01339650
- Testing
- ABT-767
- Where
- 3 sites in Netherlands
- Volunteers
- 93 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Early Breast Cancer, Ductal Breast Carcinoma In Situ
Hypofractionated Radiotherapy With Concomitant Tumor Bed Boost for Breast Cancer
Hypofractionated breast radiotherapy with concomitant tumor bed boost for early breast cancer or ductal breast carcinoma in situ after partial mastectomy
- Trial name
- HFCBB (NCT06984250)
- Testing
- Hypofractionated Radiation Therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 315 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer, Perimenopause
AMH Dynamic Changes to Predict Ovarian Reserve in Perimenopausal Breast Cancer
This study is a prospective observational cohort study aimed at developing a clinical model based on dynamic changes in anti-Müllerian hormone (AMH) to predict ovarian reserve in perimenopausal women with hormone…
- Conditions
- Breast Cancer, Perimenopause, Ovarian Reserve
- Trial name
- NCT07497191
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Breast Cancer
Exercise Interventions for Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
The BENEFIT-Study is a randomized controlled 3-arm intervention trial investigating the currently discussed hypothesis that exercise concomitant to chemotherapy (CTx) may have a beneficial effect on cancer prognosis by boosting…
- Trial name
- BENEFIT (NCT02999074)
- Testing
- Resistance exercise, Aerobic exercise, Usual care during neoadjuvant chemotherapy/Exercise after surgery
- Where
- Germany
- Volunteers
- 183 people
- Sponsor
- German Cancer Research Center
Breast Cancer
Combined Estrogen Blockade of the Breast With Exemestane and Raloxifene in Postmenopausal Women With a History of Breast Cancer Who Have No Clinical Evidence of Disease
The purpose of this research study is to learn about the effects of two drugs when they are given together. The names of the drugs are raloxifene and exemestane. Raloxifene is a drug that is related to estrogen.
- Trial name
- NCT00200174
- Testing
- Raloxifene followed by combination therapy, Exemestane followed by combination therapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
A Randomized Cluster Trial to Evaluate a Mobile Mammography Unit in Breast Cancer Screening in France (Mammobile)
Organized breast cancer screening (OBCS) has been implemented nationwide since 2004 inFrance, but the participation rate remains low (51%) and inequities in participation were reported.
- Trial name
- Mammobile (NCT05164874)
- Testing
- Mobile Mammography Unit
- Where
- France
- Volunteers
- 91,982 people, healthy volunteers welcome
- Sponsor
- Université de Caen Normandie
Breast Cancer
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer
The purpose of this trial is to inform the future clinical development of the two investigational agents in ER+ breast cancer, LEE011 (CDK4/6 inhibitor) and BYL719 (PI3K-alpha inhibitor).
- Trial name
- NCT01872260
- Testing
- LEE011, Letrozole, BYL719
- Where
- 25 sites in United States, Australia and 6 more
- Volunteers
- 259 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer
Factors Influencing Decision-Making About the Use of Chemoprevention in Women at Increased Risk for Breast Cancer
RATIONALE: Learning about how patients make decisions about using chemoprevention may help doctors plan treatment in which more patients are willing to choose chemoprevention to reduce their breast cancer risk.
- Trial name
- NCT01399359
- Testing
- Counseling session, Questionnaire 1, Questionnaire 2
- Where
- United States
- Volunteers
- 1,023 people
- Sponsor
- NSABP Foundation Inc
Estrogen Receptor-positive Breast Cancer, Fulvestrant
The Value of 18F-FES-PET/CT in Predicting Fulvestrant Efficacy in Breast Cancer
This study is focused on the value of 18F-FES-PET in predicting the Fulvestrant efficacy in hormone receptor-positive breast cancer. The imaging agent involved in this study is 16α-[18F]-fluoro-17β-estradiol (18F-FES).
- Trial name
- PET (NCT03768479)
- Testing
- 18F-FES-PET
- Where
- China
- Volunteers
- 68 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Neuro-Oncology, MRI Imaging
Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer
The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI).
- Conditions
- Neuro-Oncology, MRI Imaging, Tumor Immune Microenvironment
- Trial name
- NCT07185646
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Xiangya Hospital of Central South University
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Video-Conferenced Stress Management and Relaxation Training (VSMART) For Alabama Breast Cancer Survivors
In a sample of Alabama breast cancer survivors, the proposed study tests the feasibility and acceptability of a stress management program that has been shown to improve health and wellbeing in a general population of patients…
- Trial name
- VSMART (NCT06924788)
- Testing
- Video-Conferenced Stress Management and Relaxation Training (VSMART)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Head and Neck Cancer, Breast Cancer
Evaluation of Improved Onboard Patient Imaging
The primary objective of radiation therapy is to deliver a therapeutic dose of radiation precisely to the target while minimizing exposure to healthy surrounding tissues.
- Conditions
- Head and Neck Cancer, Breast Cancer, Upper Gastrointestinal Cancer, Lung Cancer
- Trial name
- NCT06187103
- Testing
- HyperSight Imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Varian, a Siemens Healthineers Company
Breast Neoplasms
MRI and Early Decision-making in Chemotherapy for Breast Cancer
Firstly, the investigators aim to show that breast tumour blood flow, measured as part of a standard MRI examination, decreases at the earliest stage of neoadjuvant chemotherapy in those patients who go on to respond to…
- Trial name
- CHERNAC (NCT02449824)
- Testing
- magnetic resonance imaging
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Leeds
Breast Cancer Prevention
Breast Cancer Prevention Education
We will develop and evaluate a community-based approach for disseminating comparative effective reviews (CERs) about breast cancer prevention to African American women.
- Trial name
- NCT01299623
- Testing
- Comparison of evidential versus non-evidential education on women's breast cancer prevention behaviors
- Where
- United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Metastatic Breast Cancer
1303GCC: Trastuzmab & Pertuzumab With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over.
This is a phase II study that combines Trastuzumab with Pertuzumab to see how it works in women age greater than 60 who have been diagnosed with HER2/neu overexpressed locally advanced and/or metastatic breast carcinoma.
- Trial name
- NCT02000596
- Testing
- Trastuzumab plus Pertuzumab, Hormonal Therapy with Anastrozole and Fulvestrant, Chemotherapy with Eribulin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Maryland, Baltimore
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