Clinical trials: Brain Stimulation
Mental Disorders, Delirium
Non-Invasive Brain Stimulation and Delirium
The purpose of this study is to examine whether non-invasive brain stimulation can be used to improve cognitive deficits in patients with delirium.
- Trial name
- NCT03518996
- Testing
- rTMS/iTBS/tACS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gen Shinozaki
Epilepsy
Transcranial Magnetic Stimulation to Treat Epilepsy
This study will use transcranial magnetic stimulation, or TMS (described below), to treat epilepsy in certain patients whose seizures persist despite optimum medical treatment.
- Trial name
- NCT00048490
- Testing
- transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
CP (Cerebral Palsy)
rTMS Treatment of Spasticity in Children With Cerebral Palsy/ Hemiplegia Due to ABI - a RCT
This RCT aims to investigate the effect of repetitive transcranial magnatic stimulation (rTMS) in treating children with hemiplegoc cerebral palsy.
- Trial name
- NCT06128746
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Alzheimer Disease
Application of TMS Coupled With VR for Slowing the Rate of Cognitive Decline in Patients With Alzheimer's Disease
This is a randomized sham control study to evaluate how repetitive Transcranial Magnetic Stimulation (rTMS), interactive cognitive training, or the combination of rTMS and cognitive training reduce the cognitive decline of…
- Trial name
- TMS_AD (NCT04440891)
- Testing
- TMS stimulation with X-Torp task, TMS-Stimulation with MindMotion Go
- Where
- United States
- Sponsor
- Ali Rezai
Dementia
A Culturally Appropriate Multimodal Non-pharmacological Intervention for Chinese People With Mild-to-Moderate Dementia
This is a mixed-methods research that includes a single-blind three-arms randomized control trials and a focus group study. The quantitative study aims to investigate the additional clinical benefits of the Six Arts intervention…
- Trial name
- NCT03937297
- Testing
- Six Arts, Cognitive Stimulation Therapy (CST), Usual Care
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- The University of Hong Kong
Stroke
A Novel Multimodal Approach to Promote Motor Recovery and Plasticity After Stroke
Upper extremity (UE) paresis or weakness is one of the most frequent impairments after stroke. Despite intense rehabilitation, motor and functional recovery of patients with severe hand impairments is poor.
- Trial name
- NCT07887880
- Testing
- tRNS (Transcranial Random Noise Stimulation), FES (Functional Electrical Stimulation)-assisted task-specific practice
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Utah
Hemiplegic Cerebral Palsy
Weight Bearing Exercises With NMES on Balance and Functional Abilities In Children With Hemiplegia
This study will be conducted to investigate the combining effect of weight-bearing exercises program with neuromuscular electrical stimulation on balance and functional abilities in children with hemiplegic cerebral palsy.
- Trial name
- NCT07069946
- Testing
- traditional physical therapy and weight-bearing exercise, neuromuscular electrical stimulation , traditional physical therapy and weight-bearing exercise
- Volunteers
- 30 people
- Sponsor
- Cairo University
Stroke, Acute
Robot Assisted Virtual Rehabilitation for the Hand Post Stroke (RAVR)
This study investigates the effects of intensive, high dosage task and impairment based training of the hemiparetic hand, using haptic robots integrated with complex gaming and virtual reality simulations.
- Trial name
- RAVR (NCT03569059)
- Testing
- Early Robotic/VR Therapy (EVR), Dose-Matched Usual Physical Therapy Care, Delayed Robotic/VR Therapy (DVR)
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- New Jersey Institute of Technology
Parkinson Disease
6 Month Follow up Study on the Changes of Postural Stability in Parkinsonian Patients in Response to High Frequency TMS.
Postural instability is one of the cardinal signs in Parkinson's disease (PD). It represents one of the most disabling symptoms in the advanced stages of the disease. It is associated with frequent falls and loss of independence.
- Trial name
- NCT05198076
- Testing
- High Frequency Repetitive Transcranial Magnetic Stimulation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Major Depressive Disorder, Suicide
Accelerated iTBS for Depression and Suicidality
The overall objective of this current study is to evaluate the feasibility, safety, and tolerability of "high dose" aiTBS in psychiatric inpatient and outpatients with treatment-refractory unipolar, non-psychotic major depressive…
- Trial name
- RAPID (NCT04441008)
- Testing
- Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT)
- Volunteers
- 50 people
- Sponsor
- University of Iowa
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation Surgery for Movement Disorders
Background: Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT01581580
- Testing
- Medtronic Activa Tremor Control System, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Healthy
Transcranial Magnetic Stimulation in Parkinson's Disease
This study will use transcranial magnetic stimulation (TMS) to explore how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease.
- Trial name
- NCT00023062
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Schizophrenia, Schizoaffective Disorder
Add-on HD Hf-tRNS Over Bilateral DLPFC for Treating Patients With Schizophrenia
The study aimed to investigate the effects of high-definition transcranial random noise stimulation over bilateral prefrontal cortex on psychopathological symptoms, other clinical outcomes, autonomic functioning ,and brain…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Symptoms, Neurocognitive Dysfunction
- Trial name
- NCT04038788
- Testing
- HD hf-tRNS
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Depressive Symptoms, Epilepsy, Temporal Lobe
Effects of tDCS on Depressive Symptoms of Participants With Temporal Lobe Epilepsy
This project was developed to analyze the clinical, biochemical and functional impact of tDCS on depressive symptoms in participants with temporal lobe epilepsy, intending to collaborate directly in the development of new…
- Trial name
- NCT03871842
- Testing
- active tDCS
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acquired Brain Injury
Effects of Combined Spinal Direct Current Stimulation on Upper Limb Recovery in Acquired Brain Injury
This study will compare different polarities of transcutaneous spinal direct current stimulation combined with robotic-assisted arm training (RAT) in adults with acquired brain injury (ABI).
- Trial name
- NCT03100370
- Testing
- tsDCS-Anodal Stimulation, tsDCS-Cathodal Stimulation, Robotic-assisted training of arm and hand functions
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center, Houston
Deep Brain Stimulation, Drug Resistant Epilepsy
Evaluating Modulation Effects of Temporal Interference Using SEEG
This single-center prospective study aims to investigate the electrophysiological mechanisms of temporal interference (TI) in humans by analyzing clinical, imaging, and electrophysiological data from patients aged 14-60 with…
- Trial name
- NCT06663969
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Obsessive Compulsive Disorder
China Refractory Obsessive-Compulsive Disorder Deep Brain Stimulation Study
Refractory obsessive-compulsive disorder (OCD) is a disabling condition. Deep brain stimulation (DBS) of the nucleus accumbens is the most tested therapeutic avenue for refractory OCD.
- Trial name
- CRODS (NCT02398318)
- Testing
- Bilateral Nucleus Accumbens DBS (Suzhou Sceneray)
- Where
- 3 sites in China
- Sponsor
- Ruijin Hospital
FTLD, FTD
Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration
The aim of the study is to evaluate the safety, feasibility, clinical and biological efficacy, and predictors of efficacy of an intervention consisting of repetitive transcranial magnetic stimulation (rTMS) in patients with…
- Conditions
- FTLD, FTD, bvFTD, PPA
- Trial name
- FTLD_rTMS (NCT07316413)
- Testing
- Theta burst stimulation
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Università degli Studi di Brescia
Alzheimer Disease
ADvance DBS-f in Patients With Mild Probable Alzheimer's Disease
The primary objective of this feasibility study is to evaluate the safety of DBS-f in patients with mild Alzheimer's disease by assessing all device and/or therapy related adverse events.
- Trial name
- ADvance (NCT01608061)
- Testing
- DBS-f on, DBS-f off
- Where
- 7 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- Functional Neuromodulation Ltd
Stroke
Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients
The purpose of this study is to identify and establish how the area of the brain that controls motor function (motor cortex) of the non-affected hemisphere after stroke might serve as a new target for therapeutic interventions to…
- Trial name
- NCT02544503
- Testing
- Single-pulse Transcranial Magnetic Stimulation (TMS), Paired-pulse Transcranial Magnetic Stimulation (ppTMS), Low-frequency Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University