Clinical trials: Brain Stimulation
Essential Tremor
Electroclinical Correlates in Essential Tremor
Essential tremor (ET) is a neurological disorder that affects nearly 0.9% of the world's population. High-frequency Deep Brain Stimulation (DBS) of the ventral-intermediate nuclei of the thalamus (VIM) has been proven as an…
- Trial name
- ECOLOVIM (NCT05671848)
- Testing
- Recordings of thalamic activity
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Impulsivity, Decision Making
Combined Anodal Transcranial Direct Current Stimulation (tDCS) and Cognitive Training and Decision-making
This study aims to (i) assess the effects of combined tDCS and cognitive training on decision-making on a trained task (Iowa Gambling Task; IGT); and (ii) test generalization to a closely related cognitive domain, namely motor…
- Trial name
- tDCS-CTDM (NCT03886025)
- Testing
- Anodal transcranial Direct Current Stimulation (tDCS), Cognitive training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. Najat Khalifa
Stroke, Chronic Stroke Patient
Task-oriented Training With Electrical Stimulation Glove on Hand Function and Dexterity in Chronic Stroke Patients
Stroke often causes long-lasting weakness and difficulty using the hands, which limits independence in daily life. Many patients find it hard to perform everyday tasks such as dressing, eating, or writing.
- Trial name
- NCT07160114
- Testing
- Electrical Stimulation Glove with Task-Oriented Training, Task-Oriented Training Only
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Lahore
Nervous System Diseases, Stroke
Safety and Long-term Effectiveness of High Frequency Repetitive Transcranial Magnetic Stimulation of Stroke (RAICup)
The aim of the study is to determine if 2-week repetitive transcranial magnetic stimulation at the subacute phase of stroke (between day 7 and day 14) improves significantly arm motility at 3 months with remaining effect at one…
- Conditions
- Nervous System Diseases, Stroke, Cerebrovascular Disorders, Brain Infarction
- Trial name
- RAICup (NCT01059149)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke
Peripheral Stimulation Neural Response
Few patients recover full hand dexterity after an acquired brain injury such as stroke. Repetitive somatosensory electrical stimulation (SES) is a promising method to promote recovery of hand function.
- Trial name
- NCT03176550
- Testing
- Transcutaneous electrical nerve stimulation
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
Cerebellar Ataxia
A Study on Cerebello-Spinal tPCS in Ataxia
Neurodegenerative ataxia represents a group of disabling diseases. No effective treatment is currently available for them. Currently, studies are going on the effectiveness of noninvasive neurostimulation in neurodegenerative…
- Trial name
- NCT04054726
- Testing
- Active Transcranial pulsed current stimulation (tPCS)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Western University, Canada
Parkinson Disease, Gait Disorders, Neurologic
Spinal Cord Stimulation for Gait Disorders in Parkinson's Disease
Our project is based on the fundamental hypothesis that epidural spinal cord stimulation (SCS) improves Freezing of gait (FOG) in patients with Parkinson's disease.
- Trial name
- SCM-PARK (NCT04682678)
- Testing
- Implantation of electrodes for Spinal cord stimulation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Grenoble
Stroke
tDCS and Lower Limb Performance in Stroke
Lower limb rehabilitation is especially important, as the simple act of regaining the ability to walk has subsequent effects on the ability to engage in activities of daily living .So, this study will contribute in describing the…
- Trial name
- NCT06463795
- Testing
- tDCS
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Riphah International University
Parkinson Disease
Integration of Auditory, and Deep Brain Stimulation to Enhance Deep Sleep in Parkinson's Disease
The study is an open-label trial to validate the local field potential (LFP) activity in the subthalamic nucleus (STN) for slow-wave detection during acoustic stimulation during nighttime sleep in Parkinson's disease patients…
- Trial name
- NCT05184270
- Testing
- Acoustic stimulation
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Christian Baumann
Alzheimer Disease, Mild Cognitive Impairment
Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation
Presently, few studies have evaluated the clinical impact of rTMS in Alzheimer's disease. Though some studies have demonstrated an improvement, there have been conflicting results, as others do not seem to demonstrate beneficial…
- Trial name
- StimoLaMente (NCT04866979)
- Testing
- Experimental: Continuous TBS (cTBS), Intermittent TBS (iTBS), Cognitive training (CT).
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi di Trento
Autism Spectrum Disorder
Electrical Brain Stimulation and Pharmacological Treatments in Autism Spectrum Disorder
This project aims to comparing the effectiveness of transcranial direct current stimulation with common pharmacological treatments on behavioral problems and cognitive deficits of children with autism spectrum disorder
- Trial name
- NCT05491720
- Testing
- RisperiDONE 1 MG/ML, transcranial direct current stimulation
- Where
- Iran
- Volunteers
- 45 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Transcranial Magnetic Stimulation, Complex Regional Pain Syndrome of Upper Limb (Disorder)
CRPS - Diagnostics, Pathophysiological Mechanisms, and Response to Treatment With Noninvasive Brain Stimulation
This is a sham controlled, randomized, double-blind, navigated repetitive Transcranial Magnetic Stimulation (nrTMS) study for the treatment of complex regional pain syndrome (CRPS types 1 and 2).
- Trial name
- NCT04439669
- Testing
- Active nrTMS and open phase
- Where
- 2 sites in Finland
- Volunteers
- 62 people
- Sponsor
- Helsinki University Central Hospital
Chronic Low Back Pain
Brain and Peripheral Electrical Stimulation in Chronic Low Back Pain: a Factorial Design
The purpose of this study is to evaluate the efficacy of brain and peripheral electrical stimulation on chronic non-specific low back pain patients.
- Trial name
- NCT01896453
- Testing
- Transcranial direct current stimulation (tDCS), Transcutaneous electrical nerve stimulation (TENS)
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- University of Sao Paulo General Hospital
Migraine
Intra-Nasal Mechanical Stimulation (INMEST) as a Potential Preventative Treatment for Migraine
This is a prospective, randomized, open-label, delayed-start clinical investigation evaluating the safety and efficacy of the Walther System, a Class IIa investigational medical device delivering intra-nasal mechanical…
- Trial name
- A-MI-01 (NCT07279623)
- Testing
- INMEST-treatment
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Abilion Medical Systems AB
Autism Spectrum Disorder
Medial Prefrontal Cortex Brain Magnetic Stimulation in Autism
Despite decades of research, no definitive, effective biological treatments exist for core symptoms of Autism Spectrum Disorder (ASD).
- Trial name
- NCT07770451
- Testing
- TMS
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Alzheimer Disease
Transcranial Pulse Stimulation (TPS) for Alzheimer's Disease (AD)
This is a prospective open comprehensive proof-of-principle pilot study.
- Trial name
- NCT04333329
- Testing
- NEUROLITH
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Storz Medical AG
Ischaemic Stroke
The RETRAIN Trial Phase 2
Ischaemic strokes, caused by a disruption in the brain's blood supply, are the second leading cause of death and disability in the United Kingdom.
- Trial name
- RETRAIN 2 (NCT07197996)
- Testing
- Intermittent Pneumatic Compression, geko® T3
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Firstkind Ltd
Stroke
Effects of Device-assisted Practice of ADL on Arm/Hand Recovery in Individuals With Moderate to Severe Stroke
A large number of post-stroke survivors cannot functionally use their paretic upper extremity (UE). This study therefore investigates effects of device-assisted practice of activities of daily living (ADL) in a close-to-normal…
- Trial name
- NCT04077073
- Testing
- ReIn-Hand, Robot
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Northwestern University
Mild Cognitive Impairment (MCI), Mild Alzheimer Disease
iTBS in MCI and Mild AD
This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.
- Trial name
- NCT06670820
- Testing
- Active rTMS
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Defense Medical Center, Taiwan
Parkinson Disease
Effects of Ecological Rythmic-acoustic Stimulation (E-RAS) on Motor Skills in Individuals With Parkinson's Disease
The use of rhythmic auditory stimulation (RAS) has been proven useful in the management of gait disturbances induced by Parkinson's disease (PD).
- Trial name
- NCT03228888
- Testing
- Administration of rhytmic acoustic stimuli for gait training
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Cagliari