Clinical trials: Brain Stimulation
Opioid-use Disorder
Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder
The primary aims of this study are to identify impaired cognitive control in opioid use disorder (OUD) and subsequently to examine the effects of transcranial magnetic stimulation (TMS) on reward processing, as measured by the…
- Trial name
- NCT04432493
- Testing
- Active repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Dyslexia, Dyslexia, Developmental
Impact of Non-invasive Brain Stimulation on Learning Novel Spoken Words
The purpose of the proposed study is to use transcranial magnetic stimulation (TMS) to evaluate a neurobiological model of spoken word learning in older youth.
- Conditions
- Dyslexia, Dyslexia, Developmental, Learning; Developmental Disorder, Reading
- Trial name
- NCT06387615
- Testing
- Active cTBS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Acoustic Stimulation, Parkinson Disease
Rhythmic Auditory Stimulation on Neural Activity During Finger-tapping in PD Patients
Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life.
- Conditions
- Acoustic Stimulation, Parkinson Disease, Electroencephalography
- Trial name
- NCT05839821
- Testing
- noF-noRAS, F-noRAS, noF-100RAS
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression
Brain Glucose Metabolism During Transcranial Direct Current Stimulation
With this study we will be able to dose-dependently measure real-time glucose metabolism changes after non-invasively stimulating superficial parts of the dlPFC, a commonly used target in therapeutic tDCS applications.
- Trial name
- NCT02999607
- Testing
- transcranial direct current stimulation
- Where
- Austria
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Transcranial Direct Current Stimulation (tDCS), Ageing
Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults
The goal of this randomised controlled trial is to investigate the effects of a 2-week high-frequency transcranial pulsed current stimulation (tPCS) on cognitive outcomes in older and healthy adults.
- Conditions
- Transcranial Direct Current Stimulation (tDCS), Ageing, Executive Functioning, Transcranial Electric Stimulation
- Trial name
- NCT06991764
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Basic Physiology, Brain Stimulation
Transcranial Direct Current Stimulation (tDCS) in the Primary Motor Cortex in Healthy Individuals
The main aim of this study is to assess the short-term effects of active-tDCS (a-tDCS) on the M1 regarding sensorimotor variables such as discriminative sensation, pressure pain threshold and electromyographic activity compared…
- Trial name
- NCT04148547
- Testing
- Sooma transcranial direct current stimulation device
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Mild Cognitive Impairment, Healthy Aging
Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition
Impaired working memory (WM) plays a crucial role in normal aging, in mild cognitive impairment (MCI) and cognitive decline associated with dementia, such as Alzheimer's disease (AD).
- Trial name
- NiBS-iCog (NCT04986787)
- Testing
- tACS, TMS, TIS
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Parkinson Disease
Neural Control of Breathing in Parkinson's Disease
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder.
- Trial name
- NEURON-PD (NCT06074614)
- Testing
- Hypercapnic ventilatory response, Respiratory related evoked potential, Transcranial magnetic stimulation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson Disease
The Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Anxiety in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients with anxiety.
- Trial name
- NCT05950347
- Testing
- Active Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Autism Spectrum Disorder, Intellectual Disability
TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders
The main purpose is to study brain plasticity (the changes that occur in the brain through experience) in individuals with autism spectrum disorder (ASD).
- Trial name
- NCT02836405
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Parkinson Disease
Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus…
- Trial name
- NCT06234995
- Testing
- Levodopa, Clinical DBS Setting, DBS Setting Maximizing Prefrontal Activation
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Parkinson's Disease, Healthy Controls Group - Age and Sex-matched
Innovative Biomarkers in de Novo Parkinson's Disease
This study aims at identifying potential new and innovative biomarkers in de novo Parkinson's disease patients. New finding will help phenotyping patients since the diagnosis of the disease and potentially also in the preclinical…
- Trial name
- INNOBIOPARK (NCT03940677)
- Testing
- Brain MRI, TMS-EEG, Behavioral and cognitive battery
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Stroke
Premotor Cortex: A New Target for Stroke Motor Rehabilitation
The goal of the study is to determine the effect of repetitive transcranial magnetic stimulation (rTMS) over the premotor cortex on training-related improvements in motor performance and associated neural plasticity.
- Trial name
- NCT02565199
- Testing
- rTMS Over Contralateral Hemisphere of Premotor Cortex, rTMS Over Ipsilateral Hemisphere of Premotor Cortex, Control 1: rTMS Timed 400 ms After Movement-related EMG
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Emory University
Major Depressive Disorder
Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy
This study will attempt to use magnetic resonance imaging (MRI) to take a picture of the brain to learn about changes that occur in the brain during Transcranial Magnetic Stimulation (TMS) in people receiving this treatment for…
- Trial name
- INSCAPE (NCT06043401)
- Testing
- Neuroimaging with Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy Adult Participants, Healthy Participants
Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep
This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep…
- Trial name
- CAP-TI (NCT07498270)
- Testing
- Magnetic Resonance Imaging (MRI), Broad thalamic stimulation (TI-TES), Anterior thalamic stimulation (TI-TES)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Cognitive Dysfunction
Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation
This study will test the preliminary efficacy of transcranial direct current stimulation (tDCS) to improve fatigue and cognition in women with a history of breast cancer and persistent fatigue.
- Conditions
- Breast Cancer, Cognitive Dysfunction, Fatigue
- Trial name
- NCT03143894
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Traumatic Brain Injury, Post Concussion Syndrome
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain.
- Trial name
- NCT07044596
- Testing
- Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aphasia, Stroke
Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia
The purpose of this study is to assess changes in language abilities of participants with chronic, post-stroke aphasia following an 8-week therapy period combined with brain stimulation.
- Trial name
- NCT04142866
- Testing
- Anodal transcranial direct current stimulation, Speech-Language Therapy (SLT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- City University of New York
Stroke, Able Bodied
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons.
- Trial name
- NCT07401186
- Testing
- Bipolar Neural Stimulation Electrode
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Peter C. Gerszten, MD
Older Adults (50-90 Years)
Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects.
- Trial name
- NCT01840839
- Testing
- brain stimulation
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany