Clinical trials: Brain Injuries, Acute, open to volunteers
Cardiac Arrest (CA), Brain Injuries, Acute
The Relationship Between Brain Injury Biomarkers in Cerebrospinal Fluid and Blood of Patients After Cardiac Arrest and Prognosis
This study is a single-center, prospective, observational study. After successful cardiopulmonary resuscitation for patients with cardiac arrest, they will be transferred to the emergency intensive care unit for further…
- Trial name
- NCT06624488
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tang Ziren
Cognitive Dysfunction, Acquired Brain Injury
Fareon Open Label Device Clinical Trial
The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis…
- Conditions
- Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- NCT07600320
- Testing
- Fareon device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Neurologic Decompensation, Acute, Traumatic Brain Injury
Ventilatory Parameters in Acute Neurological Injury
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP)…
- Conditions
- Neurologic Decompensation, Acute, Traumatic Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT06192342
- Where
- Argentina
- Volunteers
- 19 people
- Sponsor
- Ramos Mejía Hospital
Acute Pain, Pediatric ALL
VR-PAT and fNIRS to Identify CNS Biomarkers of Pain
This study aims to use functional near-infrared spectroscopy (fNIRS) to identify and quantify pain biomarkers during burn dressing changes and pain relief induced by virtual reality (VR).
- Conditions
- Acute Pain, Pediatric ALL, Procedural Pain, Burns
- Trial name
- NCT06303687
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Nationwide Children's Hospital
Traumatic Brain Injury, Severe Traumatic Brain Injury
Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial
The LIMIT-TBI trial is a multicenter, international, randomized, phase II clinical trial designed to evaluate the feasibility and safety of targeting a neutral fluid balance compared to standard care in critically ill adult…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Acute Brain Injury, Neurocritical Care
- Trial name
- LIMIT-TBI (NCT07625995)
- Testing
- Neutral Fluid Balance Strategy
- Where
- 3 sites in Belgium, Italy
- Volunteers
- 88 people
- Sponsor
- Erasme University Hospital
Osteoarthritis, Osteosarcoma
Clinical Orthopaedic Data Bank (Acute and Chronic)
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF)…
- Conditions
- Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy
- Trial name
- NCT00411060
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Florida
Brain Injuries, Acute, Brain Trauma
BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago).
- Conditions
- Brain Injuries, Acute, Brain Trauma, Penetrating Head Injury, Traumatic Brain Injury
- Trial name
- BRIDGE-US (NCT07636213)
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Chicago
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Stroke, Stroke, Acute
PRecisiOn Medicine In StrokE: Evolution of Plasma Brain-Derived Tau in Acute Stroke
The investigators recently identified Brain-derived tau (BD-tau) as a sensitive blood-based biomarker for brain injury in acute ischemic stroke: in patients with acute ischemic stroke, plasma BD-tau was associated with…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Cerebrovascular Disorders
- Trial name
- PROMISE-BD-100 (NCT06121336)
- Testing
- Plasma levels of BD-tau
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Acute Brain Injury
Physical Mobilisation to Acquired Brain Injury Patients in Intensive Care Units: a Prospective Cohort Study
The objective of this study is to quantify the amount of physical mobilisation provided to patients with moderate to severe acquired brain injury in Scandinavian neuro-ICs, and the association between intensity and duration of…
- Trial name
- FOOBScan2 (NCT07548580)
- Where
- 2 sites in Denmark
- Volunteers
- 198 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Brain Injury, Traumatic Brain Injury
Connectivity and Neural Signatures of Consciousness in Unresponsive States
The CONSCIUS study is a prospective, interventional study including patients with acute brain injury and impaired consciousness implanted with intracranial electrodes.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Consciousness Disorders, Seizures
- Trial name
- CONSCIUS (NCT06426615)
- Testing
- Intracranial electrodes
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
D000784, D020521
CARbon Dioxide Flooding to Reduce Postoperative Neurological Injury Following Surgery for Acute Type A Aortic Dissection
Aortic dissection is a life-threatening condition and a consequence of a tear of the innermost of the three aortic layers- the intima.
- Trial name
- CARTA (NCT04962646)
- Testing
- Carbon dioxide flooding
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Neurogenic Dysphagia, Traumatic Brain Injury
Register Study: Implementation of Pharyngeal Electrostimulation Therapy for the Treatment of Acute Neurogenic Dysphagia
Neurogenic dysphagia occurs with disruption of neurological systems or processes involved in the execution of coordinated and safe swallowing.
- Conditions
- Neurogenic Dysphagia, Traumatic Brain Injury, Stroke, Dysphagia
- Trial name
- R:IphEst (NCT05190718)
- Testing
- Pharyngeal electrostimulation
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Karl Landsteiner University of Health Sciences
All-cause Mortality, Quality of Life
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when…
- Conditions
- All-cause Mortality, Quality of Life, Disability, Intellectual, Neurological Disorder
- Trial name
- PREVENT-NEURO (NCT06819592)
- Testing
- Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- Where
- 29 sites in Australia, Canada and 1 more
- Volunteers
- 3,300 people
- Sponsor
- The George Institute
Critical Illness, Brain Injuries
Therapeutic Drug Monitoring of Beta-lactams and Renal Hyperclearance in Patients Admitted to Intensive Care for Acute Brain Injury
Augmented Renal Clearance (ARC), defined as a supraphysiological increase in renal function, is frequently observed in critically ill patients, particularly those with acute brain injury.
- Trial name
- BETALACT-ARC (NCT06999161)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Brain Injury Traumatic Mild, Brain Injuries
Screening Emotions in Adolescents at the Hospital for mTBI
The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing…
- Conditions
- Brain Injury Traumatic Mild, Brain Injuries, Brain Injuries, Acute, Head Injury With Intracranial Hemorrhage
- Trial name
- SEARCH-mTBI (NCT06370520)
- Testing
- Validated Questionnaires, Questionnaires, Clinician / Medical Record Variables
- Where
- 6 sites in United States
- Volunteers
- 2,592 people
- Sponsor
- University of California, Davis
Traumatic Brain Injury
TBI- Efficacy of Steroids in Acute Vasogenic Edema
The goal of this observational study is to learn about the impact of dexamethasone treatment in traumatic brain injury patients with vasogenic edema in the second week after the trauma, administered in centers where this…
- Trial name
- TBI-SAVE (NCT07358312)
- Volunteers
- 280 people
- Sponsor
- Meditech Foundation
Acute Ischemic Stroke, Contrast-induced Nephropathy
Serum Electrolytes and Contrast-Induced Nephropathy in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment
This study aims to evaluate the relationship between serum electrolyte levels and the development of contrast-induced acute kidney injury (CI-AKI) in patients with acute ischemic stroke undergoing endovascular therapy (EVT).
- Conditions
- Acute Ischemic Stroke, Contrast-induced Nephropathy, Acute Kidney Injury
- Trial name
- NCT07546448
- Testing
- No intervention (observational cohort study)
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Large Vessel Occlusion, Acute Ischemic Stroke
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large…
- Trial name
- NUVISTA2 (NCT07404852)
- Testing
- transcutaneous auricular vagal nerve stimulation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Washington University School of Medicine