Clinical trials: Brain Damage
Acute Brain Injury, Cognitive Dysfunction
Cognitive Function and Health-related Quality of Life After Neuro-intensive Care
The study will provide information on cognitive impairment and Health related quality of life in patients surviving 12 months after acute brain injury, generate a hypothesis of useful variables to predict cognitive impairment or…
- Conditions
- Acute Brain Injury, Cognitive Dysfunction, Delirium, Sepsis
- Trial name
- COGNI (NCT04881097)
- Testing
- no intervention
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Severe Traumatic Brain Injury With High Cerebral Pressure
Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury
Severe traumatic brain injury with increased intracranial pressure can lead to decreased cerebral blood flow. Low cerebral blood flow is responsible for secondary lesions, leading to bad prognosis.
- Trial name
- DEBITC (NCT02019810)
- Testing
- Norepinephrine, Dobutamine and norepinephrine
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy
Treatment of Bevacizumab Followed by Steroid in RN
Treatment of bevacizumab followed by steroid may have a better effect on patients with radiation-induced brain injury.This randomized trial aims to investigate whether treatment of bevacizumab followed by steroid may alleviate…
- Conditions
- Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy, Brain Injuries
- Trial name
- NCT04553510
- Testing
- Bevacizumab and steroid
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Traumatic Brain Injury, Post-concussive Syndrome
Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.
The purpose of this study is to determine whether sildenafil (Viagra®) is effective in improving cerebral blood flow and cerebrovascular reactivity inpatients who have persistent symptoms at least 6 months after a traumatic brain…
- Trial name
- NCT01762475
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Cerebral Palsy, Cerebral Palsy, Spastic
Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy
Cerebral palsy (CP), particularly the spastic diplegic subtype, is characterized by motor impairments such as spasticity and mobility limitations.
- Trial name
- HABIT-ILE (NCT07253857)
- Testing
- GROUP -A , Hand and Arm Bimanual Intensive Therapy Including Lower Extremity, GROUP-B , Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Post-traumatic Stress Disorder, Traumatic Brain Injury
Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop
In this proposal, the investigators extend their previous SPiRE feasibility and preliminary effectiveness study to examine STEP-Home efficacy in a RCT design.
- Conditions
- Post-traumatic Stress Disorder, Traumatic Brain Injury, Substance Related Disorders, Depression
- Trial name
- STEP-Home (NCT03868930)
- Testing
- STEP-Home, PCGT
- Where
- 2 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Injuries, Craniocerebral Trauma
Assessment of Head Injury in the Emergency Department Using BrainScope® Ahead® Technology
The objectives of the study are to document device performance with respect to the primary and secondary endpoints.
- Trial name
- B-AHEAD II (NCT01556711)
- Where
- 11 sites in United States
- Volunteers
- 816 people
- Sponsor
- BrainScope Company, Inc.
Speech and Language Disorder, Cerebral Palsy
Effect of mCIMT Casting on Speech-language Outcomes in Children With Hemiparesis
Modified constraint-induced movement therapy (mCIMT) has been successfully used with children who have hemiplegia (weakness or paralysis on one side of the body.) mCIMT uses a removable cast during treatment and home exercise…
- Conditions
- Speech and Language Disorder, Cerebral Palsy, Hemiplegia, Hemiparesis
- Trial name
- NCT04259814
- Testing
- Speech-language therapy (SLT), Modified constraint-induced movement therapy (mCIMT)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Shirley Ryan AbilityLab
Postcomatose Unawareness State, Minimally Conscious State
Eye Tracking Technology in the Diagnosis of Neurological Patients
Demonstrating that diagnostics of the state of consciousness and cognitive functions of patients with consciousness disorders performed using C-Eye X (based on eye-tracking technology) allows a more objective assessment of state…
- Conditions
- Postcomatose Unawareness State, Minimally Conscious State, Vegetative State, Disorder of Consciousness
- Trial name
- NCT05536921
- Where
- 5 sites in Poland
- Volunteers
- 90 people
- Sponsor
- AssisTech Sp. z o.o.
Brain Injuries, Acute, Respiration, Artificial
Brain Recovery With Automated VEntilation
Thus far, the closed-loop ventilation mode INTELLiVENT-ASV has been extensively tested in various groups of critically ill patients, and has been shown to be effective and safe in various groups of ventilated patients, including…
- Conditions
- Brain Injuries, Acute, Respiration, Artificial, Automation
- Trial name
- BRAVE (NCT06367816)
- Testing
- INTELLiVENT, Conventional ventilation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Genova
Traumatic Brain Injury
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Phase 2 Option 1
This study is being conducted to validate early and ultra-early blood-based and novel imaging biomarkers of Diffuse Axonal Injury (DAI), Microvascular Injury (MVI), and neuroinflammation that may serve as predictive and…
- Trial name
- NCT04602806
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Cerebral Palsy, Covid19
The Effect of Pandemic on Children With Cerebral Palsy
Cerebral Palsy (CP), is the most common cause of physical disability that begins in childhood and lasts throughout life, affecting 1 in 500 newborns, with an estimated prevalence of 17 million worldwide.
- Trial name
- NCT04970927
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Sevda Adar
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Metabolomic Profiling of Patients With Traumatic Brain Injury
Traumatic Brain Injury (TBI) is a significant cause of mortality and morbidity worldwide. However, the literature on determining its severity and predicting prognosis is insufficient.
- Trial name
- NCT07292766
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Traumatic Brain Injury
Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation
The purpose of this study is to examine the feasibility and preliminary efficacy of using transcutaneous auricular vagus nerve stimulation (tVNS) to enhance cognitive recovery in patients with mild-moderate traumatic brain injury…
- Trial name
- NCT06589362
- Testing
- Transcutaneous auricular vagus active nerve stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shirley Ryan AbilityLab
Cerebral Palsy, Hemiplegic Cerebral Palsy
tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy
The goal of this study is to test the efficacy of transcranial direct current stimulation combined with bimanual training on hand function in children with unilateral spastic cerebral palsy (USCP).
- Conditions
- Cerebral Palsy, Hemiplegic Cerebral Palsy, Spastic Hemiplegic Cerebral Palsy, Spastic Hemiparesis
- Trial name
- NCT03402854
- Testing
- active transcranial direct current stimulation, bimanual training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Burke Medical Research Institute
Quadriplegic Cerebral Palsy, Cerebral Palsy (CP)
Intensive Bimanual Therapy Versus Conventional Physical Therapy in Quadriplegic Cerebral Palsy
Quadriplegic cerebral palsy (CP) is a severe neurological condition affecting motor control in all four limbs, often resulting in profound functional limitations in daily activities.
- Trial name
- NCT07134894
- Testing
- Intensive Bimanual Therapy plus Conventional Physical Therapy, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Lahore
Cerebral Palsy
Acute Effects of a Passive Stretching Session on the Mechanical Properties of Medial Gastrocnemius Muscle in Children With Cerebral Palsy
Children with cerebral palsy present early in the childhood altered muscular properties, as soon as structural or stiffness. In the gastrocnemius muscle, altered muscular properties are characterized by short muscle belly length…
- Trial name
- NCT03714269
- Testing
- measurement evaluated with an isokinetic dynamometer, measurement evaluated with an 2D ultrasound, assessment of the level of discomfort
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
TBI, Brain Injury
Assessment of Dystussia in Traumatic Brain Injury
The purpose of this research study is to evaluate coughing in people who have had a brain injury. It is hypothesized that individuals who have sustained a brain injury will demonstrate differences in cough waveform and…
- Trial name
- NCT02240329
- Testing
- Neuropsychological Testing and Measures of TBI severity, Respiratory measures, Capsaicin cough sensitivity testing
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Florida
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Concussion Mild
Yoga and Female Concussion
Most research on the impact of mild Traumatic Brain Injury/Concussions have been deficit-based and focused on the impairments induced by the injury. Research shows that trauma doesn't always have negative effects.
- Trial name
- NCT07170488
- Testing
- Yoga, Yoga for wait list control
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Pittsburgh