Clinical trials: Brain Aging
Stroke, Ischemic, Stroke Syndrome
CUHK Brain Health Longitudinal Study
The goal of this study is to develop a large longitudinal cohort of individuals diagnosed with or at high risk for brain diseases (both neurological and psychiatric in nature), in order to identify risk factors that contribute to…
- Conditions
- Stroke, Ischemic, Stroke Syndrome, Stroke, Stroke, Acute
- Trial name
- BHS (NCT03592563)
- Testing
- Neuro-QoL questionnaire
- Where
- 2 sites in Hong Kong
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cognition Disorders, Brain Pathology
A Precision Rehabilitation Approach to Counteract Age-Related Cognitive Declines
This study examines the behavioral, molecular, and structural biomarkers of brain health that will allow for the stratification of individuals according to their "cognitive signature" and function.
- Conditions
- Cognition Disorders, Brain Pathology, Physical Disability, Physical Activity
- Trial name
- CogEx (NCT03696082)
- Testing
- Aerobic Activity, Resistance Training, Yoga
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Aging, Mild Cognitive Impairment
Modulating Cortical Dynamics of Dual-task Standing in MCI
The investigators have designed a brain stimulation study to understand its effect on an individual's standing, walking, and thinking abilities in older adults with and without mild cognitive impairments (MCI).
- Trial name
- NCT05680701
- Testing
- real tACS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Aging Well
ACAR Brain Health Intervention Study
The main objective of this study is to assess the effectiveness of four Total Brain Health educational programs, TBH Brain Workout (1.0 and 2.0) and TBH Memory (1.0 and 2.0), in older adults residing in independent living…
- Trial name
- NCT04208880
- Testing
- TBH Brain Workout 1.0, Brain Health Book Club, TBH Brain Workout 2.0
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Alzheimer's Disease, Down Syndrome
Multicenter Vitamin E Trial in Aging Persons With Down Syndrome
The purpose of this study is to determine the safety and effectiveness of 2,000 international units of Vitamin E (alpha tocopherol)on cognitive function of aging persons with Down syndrome.
- Trial name
- NCT01594346
- Testing
- Alpha-Tocopherol, Sugar Pill
- Volunteers
- 349 people
- Sponsor
- New York State Institute for Basic Research
Parkinson Disease, Aging
Role of Sleep on Motor Learning in Parkinson's Disease and Healthy Older Adults
People with Parkinson's disease (pwPD) often present difficulty consolidating newly learned skills into long-term memory. Sleep facilitates motor memory consolidation in healthy adults, especially in combination with targeted…
- Trial name
- TARGET-SLEEP (NCT04144283)
- Testing
- NAP, WAKE
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Cognitive Decline, Alzheimer Disease
Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study
We will conduct a Tau PET scan in cognitively normal older adults, enrolled in the Aging Brain Cohort Dedicated to Diversity Study (ABCD2-Tau) study at the University of Pennsylvania's Penn Memory Center/Alzheimer's Disease Core…
- Trial name
- ABCD2-TAU (NCT05393388)
- Testing
- [18F]AV-1451
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Multiple Sclerosis
BrainAgeMS - a Comparative Study of Brain Aging in Healthy and Patients With Multiple Sclerosis
The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
- Trial name
- BrainAgeMS (NCT06221631)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy Aging, Cognitive Function 1, Social
Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Exercise
Dementia is one of the leading causes of disability worldwide. Underlying biological mechanisms are crucial in preclinical stages of Alzheimer's disease (AD).
- Conditions
- Healthy Aging, Cognitive Function 1, Social, Cerebrovascular Circulation, Blood Flow
- Trial name
- flADex (NCT06584656)
- Testing
- Aerobic exercise condition, Resistance exercise condition
- Where
- 2 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Sleep, Cognition
Evaluating the Effects of tDCS on Sleep and Cognition in Healthy Older Adults
The goal of this interventional study is to learn if transcranial direct current stimulation (tDCS), a gentle, cost-effective and non-invasive brain stimulation technique can improve sleep brain activity during an afternoon nap.
- Conditions
- Sleep, Cognition, Healthy Aging
- Trial name
- NCT06938672
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Stroke, Aging Problems
Innovative Models in the Rehabilitation of the Elderly With Stroke Through Technological Innovation
The final goal of the present study is to propose a new approach and an innovative therapeutic plan in the post-stroke rehabilitation of elderly patients, focused on the use of robotic device, in order to obtain the beneficial…
- Conditions
- Stroke, Aging Problems, Innovative Rehabilitation Treatment Based on Robotics
- Trial name
- NCT04087083
- Testing
- Technological intervention arm, Control arm
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Aging, Healthy, Risk Reduction
The REMINDER Program for Older Adults Supported by Residential and Daycare Facilities
Dementia and mild cognitive impairment (MCI) deeply impact individuals' well-being and are expected to increase due to population aging, with global cases projected to rise to 152.8 million by 2050.
- Conditions
- Aging, Healthy, Risk Reduction, Old Age; Dementia
- Trial name
- REMINDER (NCT06733181)
- Testing
- REMINDER intervention
- Where
- Portugal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Sleep Disturbance, Aging
Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality
Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive…
- Conditions
- Sleep Disturbance, Aging, Cognitive Decline, Brain Disease
- Trial name
- HK-ASAP (NCT06170073)
- Where
- Hong Kong
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Insomnia, Sleep Disturbance
Exploration of Relationships Between Sleep, Gut Health and Cognition
Our study aims to build on emerging evidence showing relationships between gut health, sleep and brain functions. To achieve this, our study aims to test the feasibility of using non-pharmacological interventions: a…
- Trial name
- NCT05315986
- Testing
- Saffr'Inside; 30mg, Enhanced Sleep Education
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Obstructive Sleep Apnea (SAOS), Aging
Evaluation of the Impact of Sleep Apnea on Cerebral Volumetry According to Age
Sleep apnea is a common disease in the general population and more particularly in elderly subjects in whom prevalence can reach 30 % after 70 years old.
- Trial name
- VOILAGE (NCT02358811)
- Testing
- Magnetic resonance imaging (MRI), Cognitive assessment
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aging
Fatty Acid Modulation of Brain Function in Older Adults
In this crossover study, the investigtors will administer two experimental diets in a random order for one week, and each experimental diet will be preceded by a one-week, low fat control diet for a total four-week study period.
- Trial name
- NCT06192407
- Testing
- High Oleic Acid Diet, High Palmitic Acid Diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Healthy
REMINDer - A Digital Environmental Enrichment Intervention
The primary goal of this pilot study is to assess the feasibility and effectiveness for improving overall mental and physical well-being of a multimodal intervention program in older adults carried out in a digital telehealth…
- Trial name
- REMINDer (NCT06530277)
- Testing
- REMINDer (A digital environmental enrichment intervention)
- Where
- Germany
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Alzheimer's Disease
Memory Imaging of Normal Aging
The purpose of this study is to develop imaging techniques that can distinguish functional brain changes in people at high risk for dementia years prior to onset of clinical memory problems from those with normal changes of aging.
- Trial name
- NCT00315575
- Testing
- BOLD and Perfusion brain MRI
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Dementia, Alzheimer Disease
The Cognition and Flow Study
About the research There are currently 850,000 people living with dementia in the United Kingdom. It is now understand that Alzheimer's disease (AzD) can result from damaged blood vessels in the brain.
- Conditions
- Dementia, Alzheimer Disease, Mild Cognitive Impairment, Aging
- Trial name
- NCT03656107
- Testing
- Cognitive Training
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Aging, Falling
Effects of Aquatic Intervention on Fall Risk, Hazard Perception, Calendar Planning and Brain Activity During Elderly
Normal aging is associated with balance, mobility and executive functions decline that increase fall risk and influence Activity of Daily Living (ADL) and Instrumental ADL (IADL) functions such as safe road-crossing, planning and…
- Conditions
- Aging, Falling, Pedestrian Accidents, Physical Activity
- Trial name
- NCT03510377
- Testing
- Aquatic physical intervention, On-land physical intervention, Non physical intervention
- Where
- Israel
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University