Clinical trials: Brain Activity
Parkinson Disease
Effects of an Independent Walking Program With Walking Poles in People With Parkinson Disease
Study Purpose: The purpose of the study is to compare changes in activity levels and walking in people with Parkinson disease after an 8-week independent walking program with or without using walking poles.
- Trial name
- ActivatePD (NCT06908135)
- Testing
- Independent walking program using walking poles, Independent walking program without walking poles
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Pacific Northwest University of Health Sciences
Malignant Glioma, Glioblastoma Multiforme
Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma
The purpose of this study is to evaluate the safety and biologically active dose of TM-601 in adult patients with recurrent malignant glioma.
- Conditions
- Malignant Glioma, Glioblastoma Multiforme, GBM, Astrocytoma
- Trial name
- NCT00591058
- Testing
- TM-601
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- TransMolecular
Cerebellar Ataxia
Exercise Training Program for Cerebellar Ataxia
The purpose of this study is to determine whether a person's ability to adapt (i.e. short term motor learning) predicts their ability to benefit from physical therapy exercises.
- Trial name
- NCT01307176
- Testing
- Home exercise program
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Major Depressive Disorders
N-Acetyl Cysteine Supplementation in Therapy Refractory Major Depressive Disorders
The aim of this study is to evaluate the efficacy of N-acetylcysteine (NAC) add-on to antidepressant medication in treating patients who do not relieve during standard antidepressant treatment for 6 weeks at least.
- Trial name
- NCT02972398
- Testing
- N-acetylcysteine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tianjin Anding Hospital
Alzheimer Disease, Dementia
Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)
The purpose of this study was to determine whether a low dose an opiate pain medication is effective for the treatment of discomfort in patients with advanced dementia.
- Conditions
- Alzheimer Disease, Dementia, Dementia, Vascular, Pain
- Trial name
- LDOT (NCT00385684)
- Testing
- hydrocodone/APAP
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Physical Inactivity
Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease
This is a four-week pilot randomized controlled trial of a behavioral intervention in older adults at risk for Alzheimer's disease. Older participants are a subgroup from the PREVENT-AD longitudinal cohort.
- Trial name
- HABS (NCT06038643)
- Testing
- Motivational behavioural intervention and daily activities monitoring, Active Control
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Lung Diseases
Non-invasive Neustimulation and Respiratory Rehabilitation
Introduction: Respiratory diseases are associated with high rate of morbidity and mortality in Brazil. Cardiopulmonary rehabilitation through respiratory muscle training, aerobic training and strengthening of upper and lower…
- Trial name
- NCT05886647
- Testing
- Active non-invasive stimulation and inspiratory muscle training
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Suellen Andrade
Stroke, Mild Cognitive Impairment
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real…
- Conditions
- Stroke, Mild Cognitive Impairment, Vestibular Diseases, Long Covid19
- Trial name
- TeleRehab DSS (NCT06534164)
- Testing
- Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system, OTAGO Home exercise program
- Where
- 5 sites in Germany, Greece and 3 more
- Volunteers
- 460 people
- Sponsor
- University College, London
Alzheimer Disease, Physical Activity
Is Tau Protein Linked to Mobility Function?
This project will provide new data to address an important question linking Alzheimer's disease neuropathology to physical disability.
- Trial name
- SYNERGY (NCT03430648)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Wake Forest University Health Sciences
Stroke
Impact of Training on Gait and Strength in Stroke Survivors
Background: A discrepancy between strength gain and gait changes following various training programs aimed at improving gait function after stroke has been noted.
- Trial name
- NCT01818349
- Testing
- isokinetic lower-limb training, isokinetic upper-limb training
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Montréal
Stroke
Effects of Group Leisure Activities and Musical Training on Hospital Stroke Rehabilitation.
The goal of this clinical trial is to learn whether adding group leisure activities and musical training can help people recover better after a stroke during their hospital rehabilitation.
- Trial name
- RehArt (NCT07541560)
- Testing
- Standard Intensive Stroke Rehabilitation Program, Music-supported Therapy, Enriched Intervention
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassa
Chronic Cough
Effect of Gefapixant on Cough-related Brain Activity in Patients With Chronic Cough
Recently, a new drug called Gefapixant passed phase III clinical trials for cough suppression in patients with chronic cough. The goal of this clinical trial is to investigate the effect of acute and prolonged administration of…
- Trial name
- NCT05813223
- Testing
- Gefapixant
- Where
- Australia
- Volunteers
- 31 people
- Sponsor
- Stuart Mazzone
Dementia
Fasudil fOr redUcing elopemeNt and Spatial Disorientation
Fasudil, a Rho kinase inhibitor, is believed to reduce wandering behaviors of elopement and getting lost by improving spatial memory and navigation through improvements in hippocampal blood flow. Fasudil is non-sedating.
- Trial name
- FOUND (NCT04793659)
- Testing
- Oral Fasudil 90 mg/day, Oral Fasudil 180 mg/day
- Where
- 11 sites in United States, Australia
- Volunteers
- 24 people
- Sponsor
- Woolsey Pharmaceuticals
Dementia, Mild Cognitive Impairment (MCI)
Dementia and Mild Cognitive Impairment: Assessment of Cognitive Functioning, Functional Autonomy, and Neuropsychiatric Symptoms.
Dementia, in its various forms, is characterized by a generalized cognitive decline that can significantly compromise personal autonomy and quality of life.
- Trial name
- RE-MIDA (NCT07287410)
- Testing
- none - observational study
- Where
- Italy
- Volunteers
- 151 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Stroke
Life Balance and Bimanual Activities After Stroke
The Flemish version of the Life Balance Inventory (LBI), measuring central constructs of life balance, will be validated in a stroke population.
- Trial name
- NCT02650960
- Where
- 3 sites in Belgium
- Volunteers
- 92 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epilepsy
Evaluation of Direct Effects of Electric Fields on Brain
Transcranial current stimulation (tCS), a safe, tolerable technique employing weak currents (~ 1 mA) applied to the scalp, has been shown to be a promising technique in alleviating seizures in focal epilepsy patients.
- Trial name
- GALVANI PS-2 (NCT05250713)
- Testing
- Transcranial stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Movement Disorder, Tourette Syndrome
Investigation of Neurofeedback With Real-Time fMRI in Healthy Volunteers and Patients With Hyperkinetic Movement Disorders
Background: Many people can learn to use feedback about brain activity to modify that activity, but is it not known if people with Tourette syndrome can modify their brain activity.
- Conditions
- Movement Disorder, Tourette Syndrome, Healthy Volunteer
- Trial name
- NCT00885040
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ischemic Stroke, Physical Activity
Physical Activity Immediately After Acute Cerebral Ischemia
Stroke is the leading cause of adult disability in Europe and United States and the second leading cause of death worldwide and affects more than 10,000 Danes each year.
- Trial name
- NCT01560520
- Testing
- Physical activity
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Hillerod Hospital, Denmark
Healthy, Age of Probands 18 - 55 Years
Changes in Brain Activity During Mirror Therapy and Virtual Reality Therapy
The purpose of this study is to compare electroencephalographic activity in upper limb rehabilitation with mirror therapy and virtual reality rehabilitation.
- Trial name
- NCT05219682
- Testing
- electroencephalographic measurement
- Where
- Czechia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Advanced Parkinson's Disease
Clinical Study for Adaptive Deep Brain Stimulation (aDBS)Controlled by Intracerebral Activity in Parkinson's Disease
Despite its therapeutic effectiveness in Parkinson's disease (PD) the current deep brain stimulation (DBS) strategy could achieve an even better clinical result by adapting to patient's condition.
- Trial name
- ADBS (NCT02154724)
- Testing
- aDBS, DBS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico