Clinical trials: Bowel Habits, open to volunteers
Colorectal Cancer, Early Onset Colorectal Cancer
Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally. CRC pathogenesis has been associated with several risk factors (family history, germline pathogenic variants…
- Conditions
- Colorectal Cancer, Early Onset Colorectal Cancer, Diet Habit, Risk Reduction
- Trial name
- DEMETRA (NCT05732623)
- Testing
- Semi Quantitative Food Frequency Questionnaire (SQFFQ)
- Where
- 8 sites in United States, Finland and 4 more
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Constipation by Outlet Obstruction
Defecation Patterns in Constipated Patients
Chronic constipation (CC) is a common condition that affects up to 25% of the population in North America. It poses a major burden on the healthcare cost.
- Trial name
- NCT04903470
- Testing
- Bisacodyl, Atropin
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The California Medical Innovations Institute, Inc.
Low Anterior Resection Syndrome (LARS)
Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer Surgery
This study aims to evaluate the optimal timing of trans-anal irrigation (TAI) for participants with low anterior resection syndrome (LARS) who have undergone surgery for rectal cancer.
- Trial name
- EARLY-TAI (NCT07696689)
- Testing
- Water-based transanal irrigation system
- Volunteers
- 250 people
- Sponsor
- Simona Ascanelli
Rectal Cancer
The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function
This study aims to propose a novel, easy-to-operate intervention strategy that effectively improves defecation function after stoma reversal and to assess its impact on the gut microbiota.The efficacy and safety of antegrade…
- Trial name
- NCT07369830
- Testing
- Clostridium butyricum (live) Tablets(Meiya)
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Huashan Hospital
Gut Microbiome, Neurocognitive Correlates of Eating Habits
Early Avocado Exposure on Development and the Gut Microbiome in American Hispanic Infants
The goal of this clinical trial is to learn if daily avocado intake can improve growth and brain and gut health in infants. The main questions it aims to answer are: Does daily eating of avocados change which microbes live in the…
- Conditions
- Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infant Growth
- Trial name
- Guac & Grow (NCT06876935)
- Testing
- Daily avocado
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Postoperative Bowel Function, Postoperative Pain
Fentanyl vs. Remifentanil in Laparoscopic Cholecystectomy: Effects on Bowel Function and Pain
Background: Postoperative ileus (POI) is a common complication after abdominal surgery, leading to delayed gastrointestinal recovery, prolonged hospitalization, and increased healthcare costs.
- Trial name
- NCT07182097
- Testing
- Fentanyl 2 µg/kg IV bolus + 1-2 µg/kg/h infusion during anesthesia, Remifentanil 1 µg/kg IV bolus + 0.1-1 µg/kg/min infusion during anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Konya City Hospital
Dyssynergic Defaecation
Efficacy of Cognitive Behavioral Therapy Administered in Patients With Dyssynergic Defecation
The aim of this study is to evaluate the effectiveness of cognitive-behavioral therapy when used in conjunction with lifestyle modifications and pelvic floor rehabilitation.
- Trial name
- NCT07488442
- Testing
- Pelvic floor rehabilitation, Pelvic floor rehabilitation+cognitive behavioral therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ankara Etlik City Hospital
Chronic Ischemic-Hypoxic Enteropathy
Gut Oxygen Therapy for Ischemic-Hypoxic Bowel Disease
This single-center, double-blind, randomized, intra-individual crossover controlled study aims to investigate the efficacy and safety of intestinal oxygen therapy via a deep intestinal catheter as a targeted route for intestinal…
- Trial name
- NCT07621367
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Gut Microbiome, Neurocognitive Correlates of Eating Habits
Tiny Tummies - A Milk Study
This is a 12-month, 2-arm randomized controlled trial (n=150) examining whether toddlers randomized at 12 months of age to 1.5 cup-equivalents/day of cow's milk-based dairy versus oat milk-based dairy, and followed to 24 months…
- Conditions
- Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infants and Young Children, Sleep
- Trial name
- NCT07839156
- Testing
- Daily cow's milk products, Daily Oat Milk Exposure
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Anxiety, Bowel Habits
Test Anxiety on Bowel Health and Constipation in Students
This observational cross-sectional study aims to examine the relationship between test anxiety, bowel health, and constipation in university students.
- Conditions
- Anxiety, Bowel Habits, Constipation
- Trial name
- NCT07654959
- Testing
- Observational assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Dyssenergic Defecation, Straining, Hard Stools, Incomplete Evacuation
Biofeedback for Women With Dyssynergic Defecation (DD)
This research aimed to compare the effect of Biofeedback (BFB) versus Lifestyle management in form of stretching positions and patient's education position of defecation, in addition to rectal massage, and anal dilators among…
- Trial name
- DD (NCT07622732)
- Testing
- Lifestyle management in form of stretching positions and patient's education position of defecation
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Ahram Canadian University
Appendicitis, Appendectomy
Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy, Peritoneal Irrigation During Laparoscopic Appendectomy Does the Grade of Contamination Matter?
Type: prospective observational multicenter trial. Population of interest: adult patients undergoing laparoscopic appendectomy for acute appendicitis.
- Trial name
- RESIDENT1 (NCT05075252)
- Testing
- laparoscopic lavage
- Where
- Italy
- Volunteers
- 1,067 people
- Sponsor
- Niguarda Hospital
Diverticulitis of Sigmoid
Bowel Function/QoL After Elective Sigmoidectomy vs. Conservative Management for Recurrent Uncomplicated Diverticulitis
The decision to perform a surgical intervention or not after recovery from repeated uncomplicated episodes of acute diverticulitis remains controversial and the literature shows different conflicting approaches based on…
- Trial name
- NCT03994978
- Testing
- elective sigmoidectomy
- Where
- Switzerland
- Volunteers
- 252 people
- Sponsor
- University Hospital, Basel, Switzerland
Fecal Incontinence
Autologous Muscle Fiber Fragment Injections
To regenerate functional anal sphincter muscle using muscle fiber fragments that contain muscle precursor cells (MPCs)
- Trial name
- NCT05396456
- Testing
- Muscle Fiber Fragment (MFF) Injections
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Dyssynergic Defecation, Constipation
Management of Dyssynergic Defecation
The purpose of this research is to better understand constipation and improve biofeedback treatments.
- Trial name
- NCT07225803
- Testing
- Biofeedback, Inspiratory muscle training (IMT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Bowel Habits, Gut Microbiomes
Study on Changes in Gut Microbiota, Inflammatory Factors, and Bowel Habits Following Oral Administration of Recombinant B-subunit/Whole Cell Cholera Vaccine in a Community Population
This randomized, placebo-controlled clinical trial aims to investigate the effects of oral cholera vaccine administration on three aspects of gut health in healthy adult community members aged 18 years and older: (1) the…
- Conditions
- Bowel Habits, Gut Microbiomes, Inflamatory Markers
- Trial name
- NCT07873346
- Testing
- Receive recombinant B-subunit/whole-cell cholera vaccine
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial Center for Disease Control and Prevention
Healthy Lifestyle, Home Environment Related Disease
HomeStyles-Adults of Chinese Heritage
Individuals of Chinese heritage are the largest and fastest growing segment of the US Asian population. US Chinese have sociodemographic characteristics and culture that differ substantially from other US Asians, and therefore…
- Conditions
- Healthy Lifestyle, Home Environment Related Disease, Cardiometabolic Disease, Systemic Inflammatory Response
- Trial name
- NCT06136793
- Testing
- HomeStyles-China
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Spinal Cord Injuries, Neurogenic Bowel
Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury
The primary objective of this study is to gather information about the effectiveness of abdominal FES to improve bowel management time (BMT) for people with chronic SCI.
- Trial name
- NCT06345781
- Testing
- Abdominal Functional Electrical Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Craig Hospital
Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD)
Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.
The proposed study is part of a PNRR 2022 project (call "Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems," currently awaiting funding response) and represents the continuation…
- Conditions
- Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- DIETA-MICIREUM (NCT06862843)
- Testing
- Collecting questionnaires and biological samples
- Where
- 4 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
Spinal Cord Injuries, Autonomic Dysreflexia
NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI
This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury.
- Trial name
- NO AD (NCT05635851)
- Testing
- Glyceryl Trinitrate Only Product in Oromucosal Dose Form
- Volunteers
- 26 people
- Sponsor
- Simon Fraser University