Clinical trials: Bowel Disorders Functional
Irritable Bowel Syndrome (IBS)
Exercise and Vagus Nerve Stimulation in IBS
The aim of the study was to consider the possible role of exercise and vagus nerve on bowel functionality in chronic IBS and to demonstrate that exercise and transcutaneous auricular stimulation of the vagus nerve can reduce…
- Trial name
- NCT06769516
- Testing
- Auricular Vagus Nerve Stimulation (aVNS), Aerobic Exercise Therapy, Low FODMAP Diet Intervention
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Bahçeşehir University
Functional Gastrointestinal Disorders Such as Irritable Bowel Syndrome and Functional Dyspepsia, Irritable Bowel Syndrome
A Pharmacy-based Observational Study to Learn More About Iberogast Advance in the Real-world Setting
This is an observational study in which data from people with functional gastrointestinal disorders who decide on their own or by recommendation of their doctors or pharmacists to take Iberogast Advance are collected and studied.
- Conditions
- Functional Gastrointestinal Disorders Such as Irritable Bowel Syndrome and Functional Dyspepsia, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- NCT05389709
- Testing
- Iberogast (STW5-II, BAY98-7410)
- Where
- Germany
- Volunteers
- 184 people
- Sponsor
- Bayer
Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders
The Healthy Endoscopy Study
Researchers at Seattle Children's Research Institute want to find ways to understand gastrointestinal disease such as Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS) and Graft-Versus-Host-Disease (GVHD).
- Trial name
- NCT04369963
- Testing
- Esophagogastroduodenoscopy and Colonoscopy with Biopsies
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Functional Pancreatic Neuroendocrine Tumor, Malignant Somatostatinoma
Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor
This phase I trial studies the side effects and best dose of veliparib when given together with capecitabine and temozolomide in treating patients with neuroendocrine tumor that has spread to other places in the body and usually…
- Conditions
- Functional Pancreatic Neuroendocrine Tumor, Malignant Somatostatinoma, Merkel Cell Carcinoma, Metastatic Adrenal Gland Pheochromocytoma
- Trial name
- NCT02831179
- Testing
- Capecitabine, Temozolomide, Veliparib
- Sponsor
- Vanderbilt-Ingram Cancer Center
Abdominal Pain, Abdominal Discomfort
Pilot Study Studying Physiological Effects of Probiotic Pills in Patients With Abdominal Pain/Discomfort and Bloating
We are conducting a study to learn if probiotics, which are live bacteria found in food like yogurt and cheese, will improve symptoms of abdominal pain.
- Conditions
- Abdominal Pain, Abdominal Discomfort, Bloating, Functional Bowel Disorders
- Trial name
- NCT01064661
- Testing
- Single probiotic arm of L-NCFM alone, Blend probiotic arm of L-NCFM and B-LBi07
- Volunteers
- 22 people
- Sponsor
- University of North Carolina, Chapel Hill
Irritable Bowel Syndrome, Food Allergy
Endomicroscopic Evaluation of Food-induced Gastrointestinal Mucosal Alteration
The overarching goal of this study is to establish a first ever registry in the U.S. to collect outcomes data to evaluate changes in the gastrointestinal (GI) mucosa following direct food application utilizing Confocal Laser…
- Trial name
- NCT06792838
- Testing
- Confocal Laser Endomicroscopy
- Volunteers
- 200 people
- Sponsor
- Cook Children's Health Care System
Rectocele
STARR Trans-anal Resection Versus Vaginal Rectocele Repair Using Elevate: Effects on Defecatory Function
The primary objective of this study is to compare the function results between two methods for surgically repairing rectoceles: vaginal versus endo-anal surgery.
- Trial name
- RectoVerso (NCT01257659)
- Testing
- STARR rectocele repair, Elevate mesh rectocele repair
- Where
- 6 sites in France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Irritable Bowel Syndrome, Digestive System Diseases
Efficacy of a Multi-strain Probiotic in the Treatment of Irritable Bowel Syndrome
The Canadian College of Naturopathic Medicine is conducting a research study on Irritable Bowel Syndrome (IBS), a common condition in North America.
- Conditions
- Irritable Bowel Syndrome, Digestive System Diseases, Colonic Diseases, Functional, Colitis, Mucous
- Trial name
- IBS (NCT01887834)
- Testing
- Kyodophilus multi-strain probiotic capsules
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Rectal Cancer, Low Anterior Resection Syndrome
The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal Cancer
This randomized controlled trial aims to evaluate the effects of combining Kegel exercise with a single biofeedback session on bowel function, emotional distress, and quality of life in patients who have undergone low anterior…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, LARS - Low Anterior Resection Syndrome
- Trial name
- BFT in LARS (NCT07253298)
- Testing
- Kegel Exercise with Biofeedback, Kegel Exercise Only
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
Irritable Bowel Syndrome With Constipation (IBS-C)
Phase III Study to Evaluate the Efficacy and Safety of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrome
The objective of this study is to evaluate the efficacy and safety of ASP0456 in patients with constipation predominant irritable bowel syndrome (IBS-C).
- Trial name
- NCT02316899
- Testing
- linaclotide
- Where
- 61 sites in Japan
- Volunteers
- 500 people
- Sponsor
- Astellas Pharma Inc
Colorectal Cancer (MSI-H), Anxiety
Impact of Anxiety-Sleep Symptom Cluster on Immune Function and Quality of Life in Colorectal Cancer
This prospective observational study investigates the impact of the anxiety-sleep disturbance symptom cluster on cellular immune function and quality of life in colorectal cancer (CRC) patients undergoing chemotherapy.
- Trial name
- NCT07234682
- Testing
- standard-of-care chemotherapy
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Hebei Provincial Hospital of Traditional Chinese Medicine
Kolon Kanseri
Erector Spinae Plane Block in Laparoscopic Colorectal Cancer Surgery
Our study will compare patients who underwent laparoscopic surgery for colorectal cancer with and without Erector Spinae Plane Block in terms of renal blood flow and renal function tests.
- Trial name
- NCT07297433
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kayseri City Hospital
Irritable Bowel Syndrome
Evaluation of Patient Education in Irritable Bowel Syndrome
About 10% of the population in western countries suffer from abdominal pain and change of bowel habits - known as the irritable bowel syndrome.
- Trial name
- NCT00305968
- Testing
- patient education
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Colorectal Cancer, PDAC - Pancreatic Ductal Adenocarcinoma
Exploratory Clinical Evaluation of Personalized Functional Profiling in GI Tumors: Predicting Drug Response in CRC and PDAC
The ColoPan study evaluates the scientific validity, reproducibility, and predictive performance of the Personalised Functional Profiling (PFP) platform in colorectal cancer and pancreatic ductal adenocarcinoma patients.
- Trial name
- COLOPan (NCT07500259)
- Testing
- Personalized Functional Profiling
- Where
- Luxembourg
- Volunteers
- 188 people
- Sponsor
- Luxembourg Institute of Health
Food Intolerance Syndromes, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Combined Lactulose H2-breath Test With Abdominal Imaging
Hydrogen (H₂) breath tests serve several purposes. (i) detect malabsorption of carbohydrates such as lactose and fructose, (ii) measurement of oro-caecal transit time (iii) associate hydrogen production with the onset of…
- Conditions
- Food Intolerance Syndromes, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Breath Tests
- Trial name
- NCT07145580
- Where
- Switzerland
- Volunteers
- 510 people
- Sponsor
- Klinik Arlesheim
Irritable Bowel Syndrome (IBS)
Effect of HMOs as Nutritional Support for Normal Bowel Movements in IBS Patients
This is an open labeled, one-armed real-world study in IBS-patients. All participants will receive active treatment for 12 weeks.
- Trial name
- GRIPS (NCT03550742)
- Testing
- Fuco-N-Tetraose
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Glycom, Inc.
Irritable Bowel Syndrome
Prevalence of Intestinal Parasitic Infections in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is common medical disorder and represent a group of diseases of the gastrointestinal tract that is characterized by chronic abdominal pain , bloating , passage of mucus or straining with bowel…
- Trial name
- NCT05830370
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Functional Dyspepsia, Diabetic Gastroparesis
Assessment of Gastro-Intestinal Function to a Mixed Meal by Non-invasive Imaging
Dyspeptic symptoms, such as pain after eating, bloating and nausea all have major impact on quality of life and health care costs. When no structural cause is identified, patients are diagnosed with functional dyspepsia.
- Trial name
- NCT01919021
- Testing
- Magnetic Resonance Imaging MRI, Gamma Scintigraphy, Assessment of Gastric motor and sensory function
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Irritable Bowel Syndrome
Traditional Dietary Advice Versus a Low FODMAP Diet Intake in IBS Patients
The purpose of this study is to to assess if the new diet with a low-FODMAP(Fermented Oligo-, Di-, Monosaccharides And Polyols) -content yields a milder symptom picture in IBS patients compared to traditionally dietary advice in…
- Trial name
- KRIBS (NCT02107625)
- Testing
- Diet A i.e. Low FODMAP diet, Diet B, i.e. Traditional IBS diet
- Volunteers
- 75 people
- Sponsor
- Göteborg University
Spina Bifida, Neurogenic Bowel
Bowel Continence Across the Lifespan in People With Spina Bifida
The goal of this observational study is to learn how different enema programs affect bowel control in children and adults with spina bifida.
- Conditions
- Spina Bifida, Neurogenic Bowel, Bowel Incontinence
- Trial name
- BCALS (NCT07390318)
- Testing
- Retrograde Enema, Antegrade Enema
- Where
- 24 sites in United States
- Volunteers
- 943 people
- Sponsor
- David Chu