Clinical trials: Bowel Diseases, Inflammatory
Colitis, Ulcerative
A Study to Evaluate the Safety, Tolerability, PK and Preliminary Efficacy of HX15001 Combined With Etrasimod in Moderate-severe Ulcerative Colitis
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of HX15001 injection combined with Etrasimod tablets in participants with moderately to severely active ulcerative…
- Trial name
- NCT07768254
- Testing
- Biological: HX15001
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Helixon Biotechnology (Suzhou) Co., Ltd
Crohn's Disease
Small Bowel Mucosal Healing Induced by Adalimumab in Crohn's Disease Patients as Assessed by Capsule Endoscopy
The study hypothesis is that adalimumab induces mucosal healing in the small bowel and that mucosal healing correlates with disease activity.
- Trial name
- NCT01144156
- Testing
- Treatment with Adalimumab
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rabin Medical Center
Inflammatory Bowel Diseases
Study to Evaluate the Epidemiology and the Characteristics "Omics" in Patients Recently Diagnosed of Inflammatory Bowel Disease in Spain
This is a prospective, observational, multicenter, population-based incidence cohort study which will enroll cases of inflammatory bowel disease IBD (Crohn´s disease CD, ulcerative colitis UC, or indeterminate colitis) diagnosed…
- Trial name
- IBDomics (NCT03689257)
- Where
- 16 sites in Spain
- Volunteers
- 376 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Rectal Cancer, Ulcerative Colitis
Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
The primary purpose of this prospective, randomized multicenter center study is to evaluate and compare the outcomes of colorectal, coloanal and ileoanal anastomoses reinforced with a bioabsorbable staple line reinforcement…
- Conditions
- Rectal Cancer, Ulcerative Colitis, Familial Adenomatous Polyposis, Diverticulitis
- Trial name
- NCT00663819
- Testing
- GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement, Staple line without reinforcement
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- W.L.Gore & Associates
Cancer
Wormwood in Chronic Progressive Disorders With Reduced Appetite
Wormwood is approved herbal medicine for the treatment of reduced appetite in Germany (Registration No.: 1339.99.99). Reduced appetite is observed in many chronic health disorders such as old age, immune disorders and cancer.
- Trial name
- NCT01126931
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Freiburg
Colitis, Ulcerative, Inflammatory Bowel Diseases
Casein Glycomacropeptide in Active Distal Ulcerative Colitis (Pilot Study)
Casein glycomacropeptide (CGMP) has anti-inflammatory properties in experimental rodent colitis and using human in vitro inflammation models. Its use as a food ingredient has proven safe and with no influence on dietary intake.
- Trial name
- NCT01534312
- Testing
- CGMP protein, Maximal oral 5ASA
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
Colitis, Ulcerative
A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission.
- Trial name
- NCT05076175
- Testing
- Ozanimod
- Where
- 91 sites in United States, Australia and 11 more
- Volunteers
- 120 people
- Sponsor
- Bristol-Myers Squibb
Psoriatic Arthritis, Ankylosing Spondylitis
Presence of IBD Specific Antibodies (ASCA, ALCA, ACCA, AMCA) in the Sera of Patients With Spondyloarthropathy
A relationship between IBD and spondyloarthropathy is well recognized. ASCA ( anti saccharomyces cerevisiae antibodies)are considered to be a serological marker for Crohn's disease and have been studied in patients with…
- Conditions
- Psoriatic Arthritis, Ankylosing Spondylitis, Undifferentiated Spondyloarthropathy
- Trial name
- NCT00517101
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Ulcerative Colitis
Study for Safety and Tolerability of TOP1288 Administered Orally in Healthy Subjects
This study evaluates the safety and tolerability of TOP1288 oral single ascending and multiple doses in healthy subjects.
- Trial name
- NCT03071081
- Testing
- TOP1288
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Topivert Pharma Ltd
Crohn Disease
Magnetic Resonance Imaging of Motility in Crohn's 2
Crohn's disease (CD) is becoming more common. One of the main features of this disease is weight loss and malnutrition with symptoms such as tummy aches and bloating.
- Trial name
- MIC2 (NCT03052465)
- Testing
- Test soup meal feeding intervention
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Nottingham
Inflammatory Bowel Disease
Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry
The purpose of the Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry is to study the contemporary natural history of children <16 years of age newly diagnosed with inflammatory bowel disease.
- Trial name
- NCT00833170
- Where
- 28 sites in United States, Canada
- Volunteers
- 1,600 people
- Sponsor
- Connecticut Children's Medical Center
Ulcerative Colitis
Hydrogen Sulfide Detoxification and Butyrate Metabolism in Ulcerative Colitis
The purpose of this study is to evaluate the relation between sulphide detoxification and butyrate metabolism at the level of gene expression and enzyme activity in ulcerative colitis patients and healthy controls.
- Trial name
- NCT01282905
- Where
- Belgium
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Irritable Colon, Colorectal Cancer
Colon Investigation - Factors Determining Choice of Procedure
Registration of patients referred for colon investigation by barium enema, CT colonography and colonoscopy in two hospitals and one radiology centre in Telemark, Norway, for a period of minimum six months.
- Conditions
- Irritable Colon, Colorectal Cancer, Inflammatory Bowel Disease
- Trial name
- NCT00423345
- Where
- 3 sites in Norway
- Volunteers
- 750 people
- Sponsor
- Sykehuset Telemark
Major Depressive Disorder, Inflammatory Bowel Diseases
Trial of Mirtazapine for Depression in IBD
This study will test whether it is feasible to conduct a clinical trial of mirtazapine (an antidepressant tablet) in patients who have both depression and inflammatory bowel disease (IBD).
- Trial name
- MDIBD (NCT06309472)
- Testing
- Mirtazapine
- Where
- 4 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College London
Inflammatory Bowel Disease, Perianal Fistula
Perianal Fistula (PAF) Validation and Burden of Illness Study
The purpose of this study is to gain a better understanding of the disease burden and unmet need of perianal fistulas within Crohn's disease (CD) in Ontario.
- Conditions
- Inflammatory Bowel Disease, Perianal Fistula, Crohns Disease
- Trial name
- NCT03981939
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 3,032 people
- Sponsor
- Takeda
Adolescent, Child
Comparison of Partial and Exclusive Enteral Nutrition in the Treatment of Active Childhood-onset Crohn's Disease
The primary objective of this study is to determine the efficacy of a novel enteral nutrition (EN) protocol (delivering 75% of patient's caloric needs through EN) for induction of remission in patients with active childhood-onset…
- Conditions
- Adolescent, Child, Diet, Crohn Disease
- Trial name
- NCT03176875
- Testing
- ALICALM (75% of daily caloric requirements), ALICALM (100% of daily caloric requirements)
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Behcet's Syndrome, Intestinal Type
Pathogenesis of Intestinal Behcet's Syndrome
There is a direct interaction between food, intestinal flora and the intestinal barrier composed of intestinal epithelial cells and mucosal immunity, whose composition and functional alterations are theorized to be closely…
- Trial name
- NCT06026020
- Testing
- Biological samples collection
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Crohn Disease
Ultrasound Evaluation of Crohn's Disease
The purpose of this study is to assess the effectiveness of a new ultrasound technology for evaluating Crohn's disease.
- Trial name
- NCT03235180
- Testing
- Sulfur Hexafluoride, Ultrasound Elastography, Ultrasound Vascularity
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Crohn Disease, Nutrition Assessment
Comparison of Quality of Life During a Flare of Crohn's Disease Treated With Prednisolone or aCDED With PEN in Adult Patients
Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is on the rise globally. Although medical treatments have advanced, CD still leads to significant health issues due to disease progression and medication side…
- Conditions
- Crohn Disease, Nutrition Assessment, Diet Therapy
- Trial name
- CONSISTENT (NCT06953791)
- Testing
- aCDED + Modulen, Prednisolone
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- University Hospital Tuebingen
Inflammatory Bowel Diseases, Stress
SMART Program Impact on Quality of Life in Inflammatory Bowel Diseases
This research study is being done to look at the impact of a Stress Management and Resilience Training (SMART) Program on the quality of life and healthcare utilization of patients with inflammatory bowel disease.
- Trial name
- NCT06002074
- Testing
- Stress Management and Resilience Training Program
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
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