Clinical trials: Borrelia Infections
Lyme Disease
Searching for Persistence of Infection in Lyme Disease
Background: Lyme disease is an infection caused by Borrelia burgdorferi, a bacteria that is transmitted to humans by ticks. It can cause many different symptoms including rash, fever, headache, meningitis (infection of the…
- Trial name
- NCT01143558
- Testing
- Lyme Disease Xenodiagnosis
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Borrelia Recurrentis Infection
Study of the Clinical, Microbiological and Epidemiological Characteristics of Recurrent Imported Borreliosis Confirmed by the CNR Borrelia
Recurrent borreliosis (RB) is a bacterial infection transmitted by ticks or lice. These infections occur in both temperate and tropical regions, but are rare in Australia and Antarctica.
- Trial name
- BORRECUR (NCT07335965)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Strasbourg, France
Erythema Migrans
Patient's Pretreatment Expectations About Post-Lyme Symptoms
The investigators will focus on pretreatment expectations of patients with early Lyme disease manifested as erythema migrans with the aim of assessing the association between pretreatment expectations quantified with a…
- Trial name
- NCT03462329
- Testing
- Antibiotics (preferentially oral doxycycline 100 mg bid)
- Where
- Slovenia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Lyme Borreliosis, Nervous System
Study Assessing the Safety, Immunogenicity and Dose Response of VLA15, A New Vaccine Candidate Against Lyme Borreliosis
Observer-blind, partially randomized, multi-center dose escalation Phase I study in healthy adults below 40 years of age. 180 subjects will be enrolled in 6 treatment groups (different doses; different formulation: with/without…
- Trial name
- NCT03010228
- Testing
- VLA15 with Alum, VLA15 without Alum
- Where
- 5 sites in United States, Belgium
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Disease, Erythema Migrans
Erythema Migrans in Elderly
The investigators will focus on elderly patients with early Lyme borreliosis with the aim of assessing clinical course, serological response and treatment outcome of the disease as compared to younger adults.
- Conditions
- Lyme Disease, Erythema Migrans, Elderly Infection
- Trial name
- NCT03371563
- Testing
- Antibiotics, no intervention
- Volunteers
- 1,220 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Chronic Atrophic Acrodermatitis
Laboratory Characteristics in Chronic Atrophic Acrodermatitis
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with chronic atrophic dermatitis to gain better insight into pathogenesis of chronic…
- Trial name
- NCT02147262
- Testing
- doxycycline orally, 100 mg, bid, 14 days, doxycycline orally, 100 mg, bid, 28 days
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Lyme Disease
Direct Diagnosis of Disseminated Lyme Borreliosis.
Lyme borreliosis is a bacterial multisystemic infection transmitted by an Ixodes tick. It affects the skin, the joint and the brain.
- Trial name
- DIALYD (NCT04719962)
- Testing
- Targeted proteomics in skin +/- cerebrospinal or synovial fluid to diagnose disseminated Lyme disease
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
Post-Lyme Disease Syndrome (PLDS)
A Novel Nutraceutical to Combat Post-Lyme Disease Syndrome
This study will determine the effectiveness of a nutraceutical in treating the lingering effects of Lyme Disease after antibiotic treatment.
- Trial name
- PLDS (NCT04141969)
- Testing
- RLP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Optimal Health Research
Lyme Disease
Comparison of IFA and LIAISON® for Diagnosis of Early Disseminated Lyme Borreliosis in Children, Younger Than 18 Years
The aim of this study is to compare two different serological tests, IFA and LIAISON, for detection of Borrelia burgdorferi sensu lato IgM and IgG antibiodies in children with early disseminated Lyme borreliosis.
- Trial name
- NCT03798704
- Testing
- IFA, LIAISON
- Where
- Slovenia
- Volunteers
- 349 people
- Sponsor
- University Medical Centre Ljubljana
Lyme Disease
Clinical Manifestations and Long-Term Outcome in Early Lyme Neuroborreliosis
In this retrospective cohort study of patients with early Lyme neuroborreliosis (LNB), clinical and microbiologic characteristics and long-term outcome of definite vs.
- Trial name
- NCT04653558
- Where
- Slovenia
- Volunteers
- 311 people
- Sponsor
- University Medical Centre Ljubljana
Lyme Disease, Pediatric Infectious Disease
Next Generation Sequencing Detection of Lyme Disease
Next Generation Sequencing is capable of sequencing millions of small strands of DNA from a single blood sample, potentially improving its sensitivity compared to PCR testing, which only detects predetermined larger strands of…
- Conditions
- Lyme Disease, Pediatric Infectious Disease, Erythema Migrans, Lyme Arthritis
- Trial name
- NCT03505879
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Neuroborreliosis, Borrelia Burgdorferi
Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis
Comparison of Doxycycline 200 mg once daily for six weeks versus Doxycycline 200 mg once daily for two weeks + placebo for four weeks.
- Trial name
- NCT02553473
- Testing
- Doxycycline
- Volunteers
- 121 people
- Sponsor
- Sorlandet Hospital HF
Post-Treatment Lyme Disease
Meditation and Kundalini Yoga for Persistent Lyme-related Symptoms - an Online Study
This randomized, controlled study examines whether a daily practice over 8 weeks of Kundalini Yoga or Meditation can help to reduce pain and/or fatigue among patients with symptoms that persist despite prior antibiotic treatment.
- Trial name
- NCT04349605
- Testing
- Meditation, Kundalini Yoga
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Lyme Disease, Borrelia Infection
Persistent Lyme Empiric Antibiotic Study Europe
The purpose of the study is to establish whether prolonged antibiotic treatment of patients diagnosed with proven or presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term…
- Trial name
- PLEASE (NCT01207739)
- Testing
- Doxycycline, Clarithromycin and hydroxychloroquine
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Post-Treatment Lyme Disease
Ceftriaxone Pulse Dose for Post-Treatment Lyme Disease
The goal of this clinical trial is to learn if an FDA approved drug, Ceftriaxone, given intermittently, can treat people between 18 and 75 years old with a history of Lyme disease, who are still experiencing persistent or…
- Trial name
- NCT06611111
- Testing
- Ceftriaxone (Rocephin®), Dextrose 5% (D5W)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- State University of New York - Upstate Medical University
Long Covid, Post-treatment Lyme Disease Syndrome
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: Long Covid (LC) Post-treatment Lyme disease syndrome (PTLDS) Myalgic…
- Conditions
- Long Covid, Post-treatment Lyme Disease Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
- Trial name
- NCT06511050
- Testing
- Lumbrokinase
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lyme Borreliosis
Risk of Exposure and Prevention of Ticks and Tick-borne Diseases Among Foresters in Alsace
Ticks are blood-sucking arthropods that feed on vertebrate hosts. Although wild and domestic animals are the primary source of tick blood meals, humans can be an accidental host.
- Trial name
- PREFORTIC (NCT06492668)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
COVID-19, Lyme Disease
The Burden of Lyme Disease (BOLD) in a Pandemic - Insights From an Online Cross-sectional and Prospective Cohort Survey
A cross-sectional descriptive survey of the BOLD for individuals after having been ill with COVID-19 or have taken the COVID-19 vaccine will be compared with that of individuals who have neither been ill with COVID-19 nor taken…
- Conditions
- COVID-19, Lyme Disease, COVID-19 Vaccine
- Trial name
- NCT05312619
- Testing
- Cross sectional survey
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Dr. Daniel Cameron & Associates
Lyme Disease
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
This study will determine whether patients who have been infected with the Lyme bacteria, Borrelia burgdorferi, and treated with antibiotics still have the bacteria alive inside them and whether it is causing their symptoms.
- Trial name
- NCT00001539
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)