Clinical trials: Bone Substitutes
Alveolar Ridge Preservation
Novel Porous Bioceramic Material as a Bone Substitute
The aim of this study is to demonstrate that new synthetic bone graft bioceramic composites (Adaptos®-Si and Adaptos®, Biomendex Oy) are able to support the preservation of the alveolar ridge and to promote bone regeneration…
- Trial name
- NCT04719624
- Testing
- Adaptos®-Si [0.5-1 mm] (bone grafting surgery), Adaptos®-Si [1-2 mm] (bone grafting surgery), Geistlich Bio-Oss (bone grafting surgery)
- Where
- Finland
- Volunteers
- 76 people
- Sponsor
- Orton Orthopaedic Hospital
Bone Marrow Edema, Knee Pain Chronic
Subchondroplasty® Knee RCT
This is a multi-center, prospective, single-blinded, two-arm study, randomized to include approximately 134 subjects treated with Subchondroplasty (SCP) + Arthroscopy and 67 subjects with arthroscopy alone.
- Conditions
- Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee
- Trial name
- PRESERVE Knee (NCT03112200)
- Testing
- Subchondroplasty with Arthroscopy, Arthroscopy Alone
- Where
- 13 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Zimmer Biomet
Tooth Loss, Partial-edentulism
Retrospective Evaluation of a Novel Biomimetic Synthetic Bone Substitute (Creos® Syntogain)
Guided bone regeneration (GBR) is a commonly performed technique, using autogenous grafts, allografts, xenografts, or synthetic bone grafts (SBG).
- Conditions
- Tooth Loss, Partial-edentulism, Tooth Fracture, Edentulous Alveolar Ridge
- Trial name
- NCT06473545
- Where
- 2 sites in Spain
- Volunteers
- 173 people
- Sponsor
- International dentistry Research Group
Alveolar Bone Loss, Denture Complete Immediate
Interest of Bone Substitute Material in Immediate Complete Denture
More than 2 million French people suffer from the widespread disability of edentulism, with large consequences on function, nutrition, aesthetics and well-being. Complete denture is a common therapeutic strategy.
- Conditions
- Alveolar Bone Loss, Denture Complete Immediate, Bone Substitute, Replacement Material
- Trial name
- PANORAMIX (NCT02120053)
- Testing
- Conventional protocol, Bone substitute material group
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bone Regeneration, Bone Transplantation
Horizontal Ridge Augmentation With or Without Autogenous Block Grafts
To evaluate dimensional bone alterations following horizontal ridge augmentation using guided bone regeneration (GBR) with or without autogenous block graft (ABG) for the rehabilitation of atrophic jaws with dental implants.
- Conditions
- Bone Regeneration, Bone Transplantation, Bone Substitutes, Cone-beam Computed Tomography
- Trial name
- NCT03432702
- Testing
- Horizontal ridge augmentation
- Where
- Peru
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad Científica del Sur
Atrophy, Jaw, Edentulous, Partially
Comparative Results of Six Biomaterials Used in Two-stage Maxillary Sinus
Objectives: The aim of the study was to compare histological and histomorphometric results of six bone substitute materials used as graft in two-stage maxillary sinus augmentation model, after 6-month-healing.
- Conditions
- Atrophy, Jaw, Edentulous, Partially, Sinus Floor Augmentation, Bone Substitutes
- Trial name
- NCT03496688
- Testing
- Sinus floor augmentation
- Volunteers
- 6 people
- Sponsor
- University of Roma La Sapienza
Osteomyelitis, Infections
Surgical Treatment of Osteoarticular Infections Using Bioactive Bone Substitute
This prospective research project aims to evaluate the effectiveness and clinical outcomes of utilizing antibiotic-impregnated bioactive bone substitute (PerOssal®) in the surgical management of osteoarticular infections.
- Conditions
- Osteomyelitis, Infections, Fracture, Antibiotics
- Trial name
- NCT06402292
- Testing
- OSTEOMYELITIS SURGICAL TREATMENT WITH LOCAL ANTIBIOTICS AND PEROSSAL
- Volunteers
- 25 people
- Sponsor
- Federal University of São Paulo
Knee Osteoarthritis
Prospective Evaluation of Subchondroplasty in Advanced Knee Osteoarthritis.
The goal of this observational study is to evaluate the technique of subchondroplasty in patients with advanced knee osteoarthritis.
- Trial name
- NCT06027697
- Testing
- AccuFill® Porous Bone Substitute Material (BSM)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Clinique Paris-Bercy
Periodontitis (Stage 3), Minimally Invasive Surgical Procedures
Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial
This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with…
- Conditions
- Periodontitis (Stage 3), Minimally Invasive Surgical Procedures, Bone Substitutes
- Trial name
- NCT07671963
- Testing
- GTO® with NIPSA surgical approach, GenOs® + NIPSA
- Where
- 2 sites in Italy, Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Peri-Implantitis
10 Year Follow-up on Reconstructive Bone Procedures for Peri-implantitis
The purpose of this 10 year observational follow-up study was to evaluate the long-term outcomes of reconstructive surgical treatment of peri-implantitis.
- Trial name
- periimpl10y (NCT07678892)
- Testing
- Treatment with a bone graft and a membrane, Treatment with a bone graft
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Kristianstad University
Bone Substitutes, Calcium Phosphates
Biphasic Calcium Phosphate vs. Hydroxyapatite in Sinus Floor Elevation
Twenty patients scheduled for lateral-window sinus floor Elevation (SFE) are randomized into two groups: use of SYMBIOS® Biphasic Bone Graft Material (Group 1) or of Algipore® Bone Substitution Material (Group 2).
- Conditions
- Bone Substitutes, Calcium Phosphates, Hydroxyapatite, Rhodophyta
- Trial name
- NCT04331314
- Testing
- Use of Symbios Bone Graft Material, Algipore Bone Substitution Material
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Surgically Created Bone Defects or Bone Defects/Voids Resulting From Traumatic Injury
OSsIRIS Study - A Post-market Clinical Follow-up Investigation.
This is a prospective, observational, non-randomized, multicenter, international post-market clinical follow-up investigation aiming to confirm the performance and safety of the bone substitute b.Bone after implantation in…
- Trial name
- OSsIRIS (NCT06156904)
- Testing
- Bone grafting for the treatment of surgically created bone defects or bone defects/voids resulting from traumatic injury to promote healing in the pelvis, upper and lower extremities.
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 135 people
- Sponsor
- GreenBone Ortho S.p.A.
Alveolar Bone Loss
Effectiveness of Alveolar Bone Preservation in Alveoli With Infectious Process
Alveolar ridge preservation (ARP) is a surgical technique that aims to minimize the degree of dimensional changes following extraction.
- Trial name
- NCT06661863
- Testing
- alveolar ridge preservation with bioactive glass, alveolar ridge preservation with autologous bone
- Where
- Ecuador
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Hormone Deficiency, Aging
Three Month Treatment of Growth Hormone Releasing Hormone (GHRH) in the Elderly
The purpose of the study is to evaluate the effect of a naturally occurring hormone, called Growth Hormone Releasing Hormone (GHRH) on the muscle, bone, and fat tissues of the body.
- Trial name
- NCT01410799
- Testing
- Growth Hormone Releasing Hormone (GHRH )
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Bone Marrow Edema
Study for the Treatment of the Bone Marrow Edema:Core Decompression VS Bone Marrow Concentrate (BMC) VS Bone Substitute
Randomized, controlled, three-arm, double-blind study : control group, treated with core decompression technique VS subchondral plasty by injecting i-FactorTM VS injections of autologous BMC.
- Trial name
- BME-TARGET (NCT03112122)
- Testing
- autologous bone marrow concentrate, bone substitute i-FactorTM, core decompression
- Where
- Italy
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Periodontal Disease
EMD and/or Bone Substitute for the Treatment of Class II Furcations
To clinically evaluate the treatment of mandibular class II furcation defects with enamel matrix derivative (EMD) and/or a bone substitute graft make of beta tricalcium phosphate/hydroxyapatite (βTCP/HA).
- Trial name
- NCT02474498
- Testing
- EMD, βTCP/HA, Flap access surgery
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- University of Campinas, Brazil
Periodontitis, Dental Caries
Using Combination of Synthetic Bone Substitutes During Extractions
The study was designed to assess the effectiveness of conservation ridge preservation (horizontal and vertical dimension) after tooth extraction with and without combination of bone substitutes based on synthetic (calcium sulfate…
- Conditions
- Periodontitis, Dental Caries, Alveolar Bone Losses
- Trial name
- NCT01503593
- Testing
- Calcium Phosphate, Calcium Sulphate
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Chronic Periodontitis
Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects
The present clinical trial included 20 patients (11 females and 9 males, aged 36 to 56 years) suffering from moderate or advanced chronic periodontitis.
- Trial name
- NCT04643288
- Testing
- open flap debridement, n-HA bone graft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Weam Ahmed Elbattawy
Periodontitis
Clinical and Biochemical Assessment of Ozonated Olive Oil Mixed Bone Substitute in Treating Intra Bony Periodontal Defect
The goal of this study is to investigate the effect of ozonated olive oil in treating intra bony defect by means of clinical and radiographic parameters, and gingival cervicular fluid BMP2 level.
- Trial name
- NCT05655923
- Testing
- ozonized olive oil, xenograft bone substitute
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bone Substitutes, Tooth Extraction Status Nos
Adjunctive Use of Polynucleotide and Hyaluronic Acid-based Gel in Alveolar Preservation After Tooth Extraction
Alveolar ridge resorption after tooth extraction is a physiological process that continues throughout the patient's life due to the loss of the periodontal ligament and lack of mechanical stimulation.
- Trial name
- NCT06633211
- Testing
- Alveolar ridge preservation using DBBM + Regenfast + collagen matrix, Alveolar ridge preservation using DBBM + collagen matrix
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Adrià Jorba García