Clinical trials: Bone Regeneration
Patients with Posterior Maxillary Atrophy and Need for Sinus Lift Surgery to Allow Implant Placement
Efficacy of L-PRF Against Deproteinized Bovine Mineralized Bone (DBBM)
Objective: The main objective of this study is to evaluate whether the use of L-PRF combined with deproteinized bovine mineralized bone (DBBM; BioOss, Geistlich Pharma®) reduces healing time, through histomorphometric analysis…
- Trial name
- NCT06686836
- Testing
- Sinus lift augmentation with bone substitute (Bio-Oss), Open sinus lift surgery lift using Platelet- and leukocyte-rich fibrin (L-PRF) mixed with a bone substitute (Bio-Oss®(Geistlich AG, Wolhusen, Switzerland)) - L-PRF Block
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Bone Deformity
The Influence of 3D Surgical Template on the Contour of Bone Augmentation, in Patient With Labial Alveolar Ridge Defect and Simultaneous Implantation
Evaluate the impact of using 3D surgical template with guided bone regeneration technique on the contour of bone augmentation in patients with horizontal labial ridge defect and simultaneous implantation.
- Trial name
- NCT06312384
- Testing
- 3D Surgical Template on the Contour of Bone Augmentation, in Patient With Labial Alveolar Ridge Defect and Simultaneous Implantation, conventional guided bone regeneration,in Patient With Labial Alveolar Ridge Defect and Simultaneous Implantation
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Tooth Loss, Partial-edentulism
Retrospective Evaluation of a Novel Biomimetic Synthetic Bone Substitute (Creos® Syntogain)
Guided bone regeneration (GBR) is a commonly performed technique, using autogenous grafts, allografts, xenografts, or synthetic bone grafts (SBG).
- Conditions
- Tooth Loss, Partial-edentulism, Tooth Fracture, Edentulous Alveolar Ridge
- Trial name
- NCT06473545
- Where
- 2 sites in Spain
- Volunteers
- 173 people
- Sponsor
- International dentistry Research Group
Jaw Cysts, Curettage
Low-Intensity Pulsed Ultrasound as an Adjunctive Therapy for Bone Regeneration Following Jaw Cyst Enucleation
This study tested whether low-intensity pulsed ultrasound (LIPUS) could help patients recover better after surgery to remove jaw cysts. A total of 29 patients with 33 jaw cysts were included.
- Trial name
- LIPUS (NCT07210983)
- Testing
- Low-Intensity Pulsed Ultrasound
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Sadam Elayah
Periodontitis
Regeneration of Human Intrabony Defects With rhFGF-2/HA
BACKGROUND: Periodontal disease is an infection that results in progressive loss of dental support, which may lead to tooth loss..
- Trial name
- NCT02337166
- Testing
- a gel containing 4mg/ml rhFGF-2 in sodium hyaluronate, Periodontal flap surgery
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Asherman Syndrome
Pre-clinical Endometrial Tissular Renovation Study
The endometrium is a tissue with high capacity of renewal ("self-renewal"). This process is regulated by stem cells. Recent studies have shown that bone marrow-derived stem cells (BMDSCs) contribute to tissues and organs…
- Trial name
- PreENTIRE (NCT03665649)
- Testing
- CD133+ cells isolation
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Periodontal Regeneration, Minimally Invasive Surgical Technique
Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects
The goal of this clinical trial is to evaluate the efficacy of using L-PRF (leukocyte and platelet rich fibrin clot) as an autologous filling material in conjunction with the EPP (entire papilla preservation) technique for the…
- Conditions
- Periodontal Regeneration, Minimally Invasive Surgical Technique, Platelet Rich Fibrin, Microsurgery
- Trial name
- NCT06694168
- Testing
- Periodontal Regeneration, clinical and radiographic results, modified minimal invasive surgery, REGEND001 Autologous Therapy Product
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
Bone Substitutes, Bone Defect
Pre-market Study to Evaluate Safety and Performance of GreenBone Implant (Long Bone Study)
Multi-center, international, prospective, open-label, single-arm, first-in-human clinical investigation. The Patients enrolled in this clinical investigation will undergo a scheduled surgery for the treatment of long bone defects…
- Trial name
- NCT03884790
- Testing
- surgical repair of long bone defects
- Where
- 8 sites in Bosnia and Herzegovina, Israel and 4 more
- Volunteers
- 16 people
- Sponsor
- GreenBone Ortho S.p.A.
Patients Undergoing Oral Implant Therapy
The Effect of Systemic Antibiotics on Post-surgical Complications and Patient-centered Outcomes in Patients Undergoing Implant Surgery With Guided Bone Regeneration and Simultaneous Sinus Floor Elevation
The primary aim of the trial is to evaluate the effect of systemic antibiotic administration compared to placebo in patients undergoing oral implant therapy with simultaneous lateral sinus floor elevation and guided bone…
- Trial name
- NCT04552080
- Testing
- Amoxicillin
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Healthy Volunteers Only
Efficacy of Buccal Pad of Fat, Advanced Platelet Rich Fibrin, Fibrin Glue and Oxidized Cellulose Plug in Management of Oro-Antral Communication, Comparative Clinical Study
Evaluation of the efficacy of different treatment protocols in the management of Oro-Antral Communications.
- Trial name
- OAC (NCT06220877)
- Testing
- Buccal Pad of Fat, A-PRF, fibrin glue
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- October 6 University
Chronic Periodontitis
Evaluation of SilOss® in Periodontal Surgery
Siloss® (Azurebio, Madrid, Spain) is a synthetic and inorganic bone graft material and is composed of a dicalcium phosphate anhydrous (monetite), hydroxyapatite (HA), and amorphous silica and trace amounts of zinc.
- Trial name
- NCT02639572
- Testing
- Siloss® bone graft, Hydroxyapatitie Bone graft
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Coronary Artery Disease
Bone Marrow Transfer to Enhance ST-Elevation Infarct Regeneration
After successful percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction, 60 patients were randomly assigned to either a control group (n=30) that received optimum postinfarction medical…
- Trial name
- NCT00224536
- Testing
- Intracoronary bone marrow cell transfer
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Bone Graft; Complications, Infection or Inflammation, Ridge Deficency
To Compare Different Soft Tissue Grafts at the Time of Lateral Ridge Augmentation Procedure.
This study will compare two commonly used soft tissue grafting techniques (connective tissue graft, CTG vs Acellular Dermal Matrix, ADM) to augment the soft tissue at the time of lateral ridge augmentation procedure.
- Conditions
- Bone Graft; Complications, Infection or Inflammation, Ridge Deficency, Dental Implant
- Trial name
- NCT03774888
- Testing
- Connective tissue graft at time of bone graft, Acellular Demal Matrix at time of bone graft, No soft tissue grafting at time of bone graft
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Alveolar Bone Loss
Histological Outcome of the Use of Different Biomaterials for Fresh Socket Regeneration. A Split-mouth Design
Purpose: The aim of this study was to analyze the quality of bone regeneration in fresh sockets using four different materials and at different times points.
- Trial name
- NCT05183386
- Testing
- dental socket regeneration
- Volunteers
- 30 people
- Sponsor
- University of Salamanca
Fibrin/Therapeutic Use, Blood Platelets
Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery
The purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin.
- Conditions
- Fibrin/Therapeutic Use, Blood Platelets, Molar, Third, Bone Regeneration
- Trial name
- NCT02890680
- Testing
- Platelet-rich fibrin, Control group
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Tooth Extraction Site Healing, Alveolar Ridge Preservation
Biomaterials Exposed to Oral Environment: Which One is the Appropriate Option?
After tooth extraction, bone loss can compromise future dental implant treatment. Dentists often use biomaterials to preserve bone, but in many cases these materials are left exposed to the oral environment, where saliva and…
- Trial name
- NCT07589751
- Testing
- Alveolar Ridge Reconstruction
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Obesity and Type 2 Diabetes
Stem Cell Isolation From Femoral Heads Post Total Hip Arthroplasty
Femoral heads will be collected at University Hospital (London, ON, Canada) from individuals with type-2 diabetes, obesity, and no T2D/no obesity controls.
- Trial name
- NCT06775600
- Testing
- Hip Replacement
- Volunteers
- 30 people
- Sponsor
- David Hess
Intrabony Periodontal Defect
Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study
The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.
- Trial name
- NCT06426524
- Testing
- IGF-1 Gel, Hydroxyapatite
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dr R Viswa Chandra
Bone Augmentation, Bone Grafts
Filling Bone Defects/Voids With Autologous BonoFill-II for Maxillofacial Bone Regeneration
The purpose of this clinical study is to evaluate the safety and the efficacy of BonoFill-II as a bone filler containing the patient's own (autologous) adipose (fat) tissue-derived cells in reconstructing bone in two clinical…
- Trial name
- NCT02842619
- Testing
- BonoFill-II
- Where
- Israel
- Volunteers
- 27 people
- Sponsor
- BonusBio Group Ltd
Posterior Mandible With Deficient Ridge Height
Vertical Ridge Augmentation With Autogenous Onlay Blocks Combined With Guided Bone Regeneration Versus Autogenous Bone Graft With Titanium Mesh in Posterior Mandible
Atrophic ridge augmentation utilizing guided bone regeneration (GBR) has become a major treatment option to provide optimal bone support for osseointegrated dental implants.
- Trial name
- NCT03680118
- Testing
- autogenous rings with GBR and autogenous graft with ti-mesh
- Volunteers
- 24 people
- Sponsor
- Cairo University