Clinical trials: Bone Regeneration
Patients with Posterior Maxillary Atrophy and Need for Sinus Lift Surgery to Allow Implant Placement
Efficacy of L-PRF Against Deproteinized Bovine Mineralized Bone (DBBM)
Objective: The main objective of this study is to evaluate whether the use of L-PRF combined with deproteinized bovine mineralized bone (DBBM; BioOss, Geistlich Pharma®) reduces healing time, through histomorphometric analysis…
- Trial name
- NCT06686836
- Testing
- Sinus lift augmentation with bone substitute (Bio-Oss), Open sinus lift surgery lift using Platelet- and leukocyte-rich fibrin (L-PRF) mixed with a bone substitute (Bio-Oss®(Geistlich AG, Wolhusen, Switzerland)) - L-PRF Block
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Maxillary Diseases
Photobiomodulation Effects on Pain, Edema, Paresthesia and Bone Regeneration After Maxillar Surgical Disjunction
The objective of the present study will be to evaluate the efficacy of photobiomodulation (PBM) with LED in pain control, facial edema, paresthesia, bone repair and quality of life arising after maxillar surgical disjunction…
- Trial name
- NCT03814525
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Dental Implants, Tooth Extraction
Bovine-derived Xenograft With or Without L-PRF for Alveolar Ridge Preservation After Tooth Extraction: a Randomized Controlled Trial
The study is prospective randomized clinical trial that aims to evaluate the adjunctive use of L-PRF in promoting the desired vascularization and bone fill in small and large defects following tooth extraction and report on the…
- Conditions
- Dental Implants, Tooth Extraction, Bone Regeneration
- Trial name
- NCT06172114
- Testing
- Alveolar ridge preservation using sticky bone
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences
Periodontal Diseases
Immediate Post-Operative Anesthesia With Either Lidocaine or Bupivacaine
Immediate post-suturing administration of either one of two dental anesthetic solutions or a placebo prior to dismissal.
- Trial name
- NCT06293807
- Testing
- Xylocaine 2 % with 1:100,000 epinephrine, Bupivicaine 0.5% with 1:200,000 epinephrine
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Ridge Deficiency
Comparison of Dehydrated Human Amnion-Chorion and Type 1 Bovine Collagen Membranes for Guided Bone Regeneration
The objective of this randomized clinical study was to evaluate the use of dehydrated human amnion-chorion membrane as an exposed barrier for guided bone regeneration (GBR) after tooth extraction and to determine whether…
- Trial name
- GBR (NCT03290638)
- Testing
- Guided Bone Regeneration (GBR)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Samer Faraj
Furcation Defects, Periodontitis
Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis
Purpose: The proposed study will evaluate and compare the clinical response of using bioresorbable collagen membrane alone or defect debridement with erbium Laser irradiation in conjunction with bioresorbable collagen membrane in…
- Conditions
- Furcation Defects, Periodontitis, Alveolar Bone Loss Beyond Furcation
- Trial name
- NCT01522131
- Testing
- bioresorbable membrane alonewill be used for regeneration of the periodontium(control)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Guided Bone Regeneration
Evaluation of Horizontal Bone Gain in the Lower Posterior Partially Edentulous Patient Comparing the Stabilization of Membranes With and Without Tacs
To address the gap of knowledge in comparing between the bone augmentation outcomes with or without tacks for membrane stabilization
- Trial name
- NCT06257225
- Testing
- Guided Bone regeneration
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth Extraction
Combination Therapy Effect of Laser on Wound Healing and Bone Regeneration of Dental Sockets
The goal of this clinical trial is to learn if the laser works to improve wound healing and bone regeneration after tooth extraction.
- Trial name
- NCT06552936
- Testing
- Diode Laser 980 nm.
- Where
- 2 sites in Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Sharif Medical Research Center
Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy
Evaluating The Use of CGF Made Gel in Mandibular Extraction Sites of Lower Impacted 3rd Molars.
The goal of this clinical trial is to learn if Concentrated Growth Factor (CGF) Gel help improve bone healing and reduce pain after the surgical removal of impacted lower third molars.
- Conditions
- Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy, Postoperative Pain Management in Oral Surgery, Concentrated Growth Factor for Extraction Socket Healing
- Trial name
- CGF (NCT07520097)
- Testing
- Concentrated Growth Factor (CGF) Gel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bone Loss, Alveolar
Tenting Screws in Combination With Platelet Concentrate for Vertical Alveolar Ridge Augmentation
Alveolar bone resorption often occurs after tooth extraction. At present, guided bone regeneration technique is widely used in clinic since it leads to less trauma and less complications.
- Trial name
- NCT04835532
- Testing
- guided bone gereration
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bone Regeneration, Tissue Engineering
In Vivo Investigation of 6 Membranes Including Their Physical, Chemical and Biological Properties.
A wide range of resorbable and non-resorbable membranes have been investigated over the last decades. Barrier membranes protect bone defects from ingrowth of soft tissue cells, provide mechanical stability of the defect area and…
- Trial name
- NCT05443776
- Testing
- Biomaterial implantation
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Ridge Preservation, Bone Regeneration
Socket Preservation Procedure Studying Soft and Hard Tissue Outcomes
Two different surgical protocols for socket preservation were compared. Soft and hard tissue outcomes were measured clinically and radiographically at baseline and six months post operatively.
- Trial name
- NCT03497403
- Testing
- Socket preservation control, Socket preservation experimental
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Harvard School of Dental Medicine
Alveolar Bone Loss, Alveolar Ridge Abnormality
Repeated Injection of I PRF and Autogenous Bone Graft for Alveolar Ridge Augmentation
The current st udy's objective was to validate the repeated effect of i PRF with autogenous bone on the of gingival thickness , width a n d volumetric bone changes durig maxillary alveolar augmentation using cone beam computer…
- Trial name
- I-PRF (NCT06711250)
- Testing
- khoury technique, khoury technique with i-PRF injections
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Guided Bone Regeneration
Assessment of Guided Bone Regeneration in Atrophic Anterior Maxilla
Guided bone regeneration (GBR) is a surgical technique that uses barrier membranes to promote osteoblast cells proliferation and exclude other cells such as epithelium and connective tissue cells.
- Trial name
- NCT03840681
- Testing
- Augmentation
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Horizontal Deficiecy in Maxillary Arches
Horizontal Maxillary Ridge Augmentation With Sticky Bone Versus Collagen Membrane GBR
Guided bone regeneration (GBR) using bone graft and barrier membrane is a well-established technique for augmentation of atrophic alveolar ridges.
- Trial name
- NCT03697616
- Testing
- Ridge augmentation with sticky bone and GBR
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Implants
Peri-implant Soft Tissue Changes at Small Buccal Dehiscences
This study was designed to assess peri-implant soft tissue health, volume and marginal stability at implants sites which presented small buccal bone dehiscences (<3mm evaluated in a vertical direction) at the time of insertion.
- Trial name
- NCT07501715
- Testing
- Connective tissue graft, horizontal guided bone regeneration
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Oral Soft Tissue Conditions
Peri Implant Soft Tissue Healing in Single Implant Restoration Using Two Different Techniques
The aim of the present study was to propose the employment of Bio-Oss® and Bio-Gide® at implant site in order to evaluate if the increased bucco-lingual bone thickness could enhance the stability of peri implant soft tissue, when…
- Trial name
- NCT02513368
- Testing
- augmentation procedure with Bio-Oss® and Bio-Gide®, augmentation procedure with connective tissue graft
- Where
- 2 sites in Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Firenze and Siena, Napoli, Italy
Guided Bone Regeneration, Bone Formation
Semi-rigid Shell Barrier System for Alveolar Bone Augmentation (SSBS for ABA)
This study aims to compare the clinical outcome before and after augmentation in case series of 10 patients. The main question it aims to answer is Whether the semi-rigid shell system facilitates bone regeneration in moderate to…
- Trial name
- SSBS (NCT06295055)
- Testing
- Ridge augmentation with semi-rigid shell barrier system
- Where
- Thailand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Bone Regeneration
Comparative Study of Three Collagen Membranes: 1 Non-cross-linked and 2 Cross-linked
This study is being done to compare how quickly three different types of collagen membranes break down when they are exposed to the mouth.
- Trial name
- NCT06944639
- Testing
- Membrane Jason MB GmbH Non-cross-linked (NCL), Membrane BioMend Extend Glutaraldehyde cross-linked, Membrane OSSIX Agile Ribose cross-linked (RCL)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Andrea Ravida
Periodontal Diseases, Periodontal Bone Loss
3D Printed Customized Bone Graft for Alveolar Regeneration: Longitudinal Cohort Evaluation
This study will evaluate the behavior of the implant-supported restorations (prosthesis) placed into the areas grafted with the 3D printed customized bone (personalized graft produced to fit a specific bone defect), as well as…
- Trial name
- NCT07405918
- Testing
- Clinical evaluation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Guarulhos