Clinical trials: Bone Markers
Bone Remodeling, Energy Metabolism
Retrospective Monocentric Evaluation of Biomarkers Associated With Bone, Muscle and Energy Metabolism
Bone is a metabolically active tissue undergoing continuous remodeling through the coordinated actions of osteoclasts (resorption), osteoblasts (formation), and osteocytes (regulation).
- Trial name
- OVAD (NCT07454252)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Coronary Disease
Platelet Activation Markers in Pediatric Cardiac Surgery
In this study the focus will be on correlating the levels of platelet activation markers (proteins that are released when blood cells are activated)to the duration of cardiopulmonary bypass, temperature during cardiopulmonary…
- Trial name
- NCT00450151
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Weill Medical College of Cornell University
Peritoneal Dialysis Patients
The Effects of Isoflavones on Cardiovascular and Bone Metabolism Markers in Peritoneal Dialysis Patients
The aim of this double-blind randomized clinical trial is to determine the effects of isoflavones on cardiovascular disease risk factors, bone metabolism markers, serum concentrations of fructoseamine and advanced glycated end…
- Trial name
- NCT03773029
- Testing
- soy isoflavone
- Where
- Iran
- Volunteers
- 47 people
- Sponsor
- National Nutrition and Food Technology Institute
Myelodysplastic Syndromes
Safety of Lenalidomide and Markers for Disease Progression in Patients With International Prognostic Scoring System (IPSS) Low- or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) With Isolated del5q
The purpose of this study is to determine the safety of lenalidomide and markers for disease progression in the treatment of IPSS low- or intermediate-1 risk MDS with isolated del5q.
- Trial name
- MDS-LE-MON-5 (NCT01081431)
- Testing
- Lenalidomide
- Where
- 12 sites in Germany
- Volunteers
- 91 people
- Sponsor
- Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH
Diabetes Mellitus, Type 2, Bone Fragile
Bone Turnover in Type 2 Diabetes and Non-diabetes Controls (DiaMarv)
Type 2 diabetes (T2D) is related to an increased risk of major fractures which does written in English. The summary is used not only increase society health care costs, but also increase the morbidity and in the recruitment of…
- Trial name
- DiaMarv (NCT05585697)
- Testing
- None - crossectional
- Where
- Denmark
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hormone Sensitive Resected Primary Breast Cancer in Postmenopausal Women
A Study to Evaluate the Effect of Letrozole and Tamoxifen on Bone and Lipids in Postmenopausal Women With Breast Cancer
Estrogen is known to be a regulator of bone and lipid metabolism. Letrozole is a potent inhibitor of estrogen synthesis. This study evaluated the effects of letrozole and tamoxifen on bone and lipid metabolism in postmenopausal…
- Trial name
- NCT00171704
- Testing
- Letrozole, Tamoxifen
- Where
- 13 sites in Denmark, United Kingdom
- Volunteers
- 263 people
- Sponsor
- Novartis Pharmaceuticals
Pulmonary Disease, Chronic Obstructive, Osteoporosis
Chronic Obstructive Pulmonary Disease (COPD) and Osteoporosis
The main objective is to study important factors in the patho-physiology of osteoporosis in patients with COPD. Therefore, the investigators will study biological markers in plasma and urine and correlate them to markers of bone…
- Trial name
- NCT01067248
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Multiple Myeloma
Study of 4 Bone Turnover Markers in Patients With Multiple Myeloma Treated With Intravenous Bisphosphonate in Routine Care
The aim of this study is looking at the Kinetics of bone turnover markers (C-terminal telopeptides of type I collagene (CTX), amino-terminal telopeptide of type 1 collagen (NTX), Dickkopf-1 (DKK-1) and Sclerostin (SOST)) in serum…
- Trial name
- AMBROBiMM (NCT04111809)
- Testing
- Blood and urine collection
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Unspecified Disorder of Bone Density and Structure
Mg Induced Changes From Day 0 to Day 28 on Serum and Urine Bone Metabolic Parameters in 70 y Old Females (no 50).
Calcium and vitamin D substitution has for a long time been used to improve osteoporosis.The main storage place for magnesium is in the bone.
- Trial name
- parathormon (NCT02549521)
- Testing
- Oral magnesium substitution
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Osteoporosis
Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density
This study will compare the effects of Zoledronic acid and Raloxifene in reducing bone turnover markers in postmenopausal women with low bone mineral density over 6 months.
- Trial name
- NCT00431444
- Testing
- Raloxifene, Zoledronic acid
- Where
- 17 sites in United States
- Volunteers
- 110 people
- Sponsor
- Novartis
Osteoporosis, Diabetes Mellitus
A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers
Diabetes mellitus is a common disease with much impact on human's health and is related to osteoporosis. But the mechanism remains unclear.
- Trial name
- NCT02429232
- Testing
- Pioglitazone, Linagliptin
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Growth Hormone Deficiency
Adult Growth Hormone Deficiency and Cardiovascular Risk
This protocol will assess the cardiovascular risk associated with growth hormone deficiency in adults. We will use multiple modalities to assess risk for heart attacks or strokes including blood work, ultrasound, MRI and…
- Trial name
- NCT00720902
- Testing
- Blood draws, growth hormone releasing hormone (GHRH) & arginine, Carotid ultrasound
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Osteoporosis
The Change of Bone Markers After Low Dose Alendronate in Postmenopausal Women With Bone Loss
High bone turnover with the bone resorption exceeding bone formation is a major mechanism of postmenopausal osteoporosis. Therefore, inhibition of bone resorption is a rational approach for the prevention.
- Trial name
- NCT00460057
- Testing
- Alendronate
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Eulji University Hospital
Prostate Cancer, Breast Cancer
Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer
Bisphosphonates have been used extensively in the treatment and the prevention of skeletal complications associated with bone metastases in patients with breast cancer and prostate cancer.
- Conditions
- Prostate Cancer, Breast Cancer, Bone Metastasis
- Trial name
- NCT00334139
- Testing
- Zoledronic Acid
- Where
- Germany
- Volunteers
- 411 people
- Sponsor
- Novartis Pharmaceuticals
Image Changes of Lumbar Fusion, Bone Turnover Markers
The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion
Many patients who have lumbar degenerative disease suffer from osteoporosis or reduced bone mass or low bone mineral density. Among patients with lumbar degenerative disease, some need fusion surgery.
- Conditions
- Image Changes of Lumbar Fusion, Bone Turnover Markers, Bone Mineral Density
- Trial name
- NCT01310465
- Testing
- zoledronic acid, sodium chloride
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fudan University
Hip Fractures, Osteoporosis
Zoledronate Early to Hip Fracture Patients - Safe and Effective?
To prevent hip fracture patients for having another fracture, secondary fracture preventing medication should be given as soon as possible.
- Trial name
- ZEBRA (NCT05025293)
- Testing
- Zoledronic Acid 5Mg/Bag 100Ml Inj, sodium chloride
- Where
- Norway
- Volunteers
- 228 people
- Sponsor
- Lene Bergendal Solberg
Growth Hormone Deficiency
Adipose Tissue and Circulating Markers of Inflammation in GH Deficiency and Changes With GH Therapy
In order to examine the effect of GH on adipose tissue inflammation, this study will examine adipose tissue and serum inflammation in patients with GH deficiency before and after GH therapy.
- Trial name
- NCT03225755
- Testing
- Growth hormone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Primary Aldosteronism
The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is a disorder of the adrenal gland causing an autonomous overproduction of mineralocorticoids, leading to arterial hypertension. Although rare, it is the most frequent cause of secondary hypertension.
- Trial name
- NCT02216721
- Where
- Malaysia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
Osteosarcoma, Ewing's Sarcoma Family of Tumors
Markers of Anthracycline-Related Cardiac Muscle Injury
Anthracycline antibiotics are included in the chemotherapy regimens of approximately 82% of patients with bone cancer and 44% of those with soft tissue sarcoma diagnosed in childhood or adolescence.
- Conditions
- Osteosarcoma, Ewing's Sarcoma Family of Tumors, Rhabdomyosarcoma, Non-rhabdomyosarcoma Soft Tissue Sarcomas
- Trial name
- NCT01112800
- Sponsor
- St. Jude Children's Research Hospital
Jaw, Edentulous
Release of Osteogenic Markers in Immediately and Non-loaded Dental Implants
The aim of this study was to compare the release of the osteoprotegerin (OPG), transforming growth factors (TGF-α), osteocalcin (OCN), osteopontin (OPN), and parathyroid hormone (PTH) during osseointegration of dental implants…
- Trial name
- NCT01909999
- Testing
- Osteogenic markers Evaluation, Clinical parameters evaluation, Implant instalation
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Renato Correa Viana Casarin