Clinical trials: Bone Diseases, Metabolic
Elderly, Metabolic Syndrome
Metabolic Syndrome and Vitamin D Level in Old People
In 2012, a cross-sectional survey sampling 1,966 community-dwelling old people was conducted. Structurized questionnaires were interviewed face-to-face by well-trained staffs.
- Conditions
- Elderly, Metabolic Syndrome, Vitamin D Deficiency, Ostreocalcin
- Trial name
- NCT03344718
- Where
- Taiwan
- Volunteers
- 549 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Cockayne Syndrome, Skin Neoplasms
Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility.
- Conditions
- Cockayne Syndrome, Skin Neoplasms, Xeroderma Pigmentosum, Trichothiodystrophy Syndromes
- Trial name
- NCT00001813
- Where
- United States
- Volunteers
- 709 people
- Sponsor
- National Cancer Institute (NCI)
Osteoporosis
The Relationship Between Vitamin D, Fingernail Thickness and Bone Density
Vitamin D deficiency is common in the elderly and contributes to the increased incidence of falls, hip fracture and depression in this population.
- Trial name
- NCT00006196
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Age-Related Bone Loss, Bone Loss, Age Related
Radio-frequency Identification (RFID) Osteoporosis Pilot Study
This examines in-vivo microwave sensing to measure a radio- frequency signal propagating through the wrist and, based on this information, establish a correlation of measured parameters with the integral bone density.
- Trial name
- NCT03385941
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neva Electromagnetics, LLC
Arthropathy, Neurogenic, Diabetes Complications
Characterization of Local and Systemic Bone Markers in Diabetes Patients With Charcot Osteoarthropathy
The study is designed to investigate biomarkers related to bone turnover in diabetics with charcot foot. This is done by measuring local blood samples in the feet, and systemically in a vene and an artery.
- Conditions
- Arthropathy, Neurogenic, Diabetes Complications, Diabetes Mellitus
- Trial name
- NCT02386579
- Testing
- Blood sample measurements
- Volunteers
- 5 people
- Sponsor
- Bispebjerg Hospital
Bone Loss
CAD-CAM PEEK Framework for All-on-4 Implants
This study was conducted to evaluate the clinical peri-implant soft tissue changes during the first year after occlusal loading and the ridge base relation after 3 years for mandibular computer-aided design and computer-aided…
- Trial name
- NCT06017596
- Testing
- PEEK framework
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Bone Atrophy, Alveolar, Bone Loss
Tunnel Access for Horizontal Alveolar Ridge Augmentation
Minimally invasive procedures with the tunnel technique have been suggested to decrease patient post-operative discomfort and morbidity in oral bone regeneration.
- Conditions
- Bone Atrophy, Alveolar, Bone Loss, Bone Resorption, Alveolar Bone Loss
- Trial name
- NCT06424223
- Testing
- Horizontal Ridge augmentation
- Where
- Italy
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Hypochondroplasia
Open-Label, Long-Term, Extension Study of Infigratinib in Children With Hypochondroplasia
Phase 2, multicenter, OLE study to evaluate the long-term safety, tolerability, and efficacy of infigratinib, an FGFR (fibroblast growth factor receptor) 1-3-selective tyrosine kinase inhibitor, in participants with…
- Trial name
- NCT07393373
- Testing
- Infigratinib
- Where
- 24 sites in United States, Australia and 8 more
- Volunteers
- 135 people
- Sponsor
- QED Therapeutics, a BridgeBio company
Osteogenesis Imperfecta, Rare Bone Disorders
Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis
MOSAIC aims to determine whether oro-dental morphological anomalies, particularly palatal morphology, associated with rare bone and cartilage diseases can be precisely characterized using 3D digital models analysed through…
- Conditions
- Osteogenesis Imperfecta, Rare Bone Disorders, Hypophosphatemia, X-Linked
- Trial name
- MOSAIC (NCT07666269)
- Testing
- intra-oral 3D optical impression
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Osteoporosis
A Phase III Clinical Study of Minodronate Tablets in Postmenopausal Women With Osteoporosis
In the randomized, active-controlled, double-blinded, multicenter study, the efficacy and safety of monthly oral minodronate were examined and compared to that of weekly oral alendronate.
- Trial name
- NCT05305183
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Acromegaly
PegvisOMant and the Immune SystEm (PROMISE)
This is a prospective observational pilot study for the evaluation of immune cells phenotype in acromegalic patients in comparison with a control population and to investigate the impact of disease control and different medical…
- Trial name
- NCT05069324
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- University of Roma La Sapienza
Post-menopausal Osteoporosis
3 yr Efficacy & Safety Study of Zoledronic Acid in Post-menopausal Women With Osteoporosis Treated With Zol Acid for 6 Yrs
This second extension will evaluate the efficacy and long term safety of zoledronic acid in women with post-menopausal osteoporosis
- Trial name
- NCT00718861
- Testing
- Zoledronic acid
- Where
- 57 sites in United States, Argentina and 16 more
- Volunteers
- 190 people
- Sponsor
- Novartis Pharmaceuticals
Osteoporosis
The Added Value of Bone Microstructure Assessment in the Management of Osteoporotic Bone
1. To assess the clinical utility of trabecular bone score (TBS) on fracture risk prediction including the new version (TBS V4) and future TBS versions at the spine and hip. 2.
- Trial name
- ADVANTAGE BONE (NCT06513442)
- Testing
- Trabecular bone score software
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Polycystic Ovary Syndrome
Plasma Levels of GDF-9 and GDF-15 in Patients With Polycystic Ovary Syndrome.
The purpose of this study is to determine the plasma levels of GDF-9 and GDF-15, and their association with bone and cardiovascular parameters in patients with Polycystic Ovary Syndrome.
- Trial name
- NCT01644305
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Ankara Education and Research Hospital
Osteoporosis, Postmenopausal
Mechanisms of Anabolic Osteoporosis Therapy
The aim of this study is to investigate the effect of romosozumab on bone cells during early and late phases of treatment.
- Trial name
- NCT05688969
- Testing
- early versus late biopsy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Postmenopausal Osteoporosis
The Deferasirox-calcium-vitamin D3 Therapy for Postmenopausal Osteoporosis (PMOP)
In 2006, Weinberg proposed a hypothesis that iron accumulation was a risk factor for osteoporosis. Osteoporosis is a common complication in various diseases, such as hemochromatosis, African hemosiderosis, thalassemia, and sickle…
- Trial name
- PMOP (NCT02854722)
- Testing
- Deferasirox and calcium-vitamin D3, Calcium-vitamin D3
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Vitamin D Deficiency
The Effect of Vitamin D Supplements on Vitamin D Status, Cardiometabolic Health and Immune Defense in Danish Children
The main purpose of this study is to investigate whether and in which doses vitamin D intake is needed in order to maintain an adequate vitamin D status in 4-8 year-old Danish children during wintertime.
- Trial name
- ODIN Junior (NCT02145195)
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Morbid Obesity Requiring Bariatric Surgery
Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?
The goal of this observational study is to evaluate whether preoperative fat-free mass predicts post-operative weight loss in patients undergoing Roux-En-Y gastric bypass.
- Trial name
- FLAG (NCT07565051)
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University Hospital, Geneva
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies
This phase II trial studies how well giving fludarabine phosphate, melphalan, and low-dose total-body irradiation (TBI) followed by donor peripheral blood stem cell transplant (PBSCT) works in treating patients with hematologic…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01529827
- Testing
- fludarabine phosphate, melphalan, total-body irradiation
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Roswell Park Cancer Institute
Arthralgia
Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
Many women with breast cancer are treated with a class of drugs called aromatase inhibitors (mainly letrozole or anastrozole), which lowers the amount of estrogen being produced in the body.
- Trial name
- NCT00111241
- Testing
- aromatase inhibitors (letrozole, anastrozole)
- Where
- Australia
- Volunteers
- 115 people
- Sponsor
- Monash University
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