Clinical trials: Bone Aging
Vitamin D Deficiency
How Much Vitamin D is Required to be Protective Against Deficiency During the Winter Months?
Vitamin D is essential to bone health. In Canada, it is obtained by sunlight exposure of the skin (between April and October) or by a few foods such as fatty fish, eggs or fortified milk and margarine.
- Trial name
- NCT01437696
- Testing
- Vitamin D
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- McGill University
Post Menopausal Osteoporosis
Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal Osteoporosis
Post-menopausal osteoporosis and the resulting fractures are an important cause of disability and loss of independence. They also increase the risk of morbidity and mortality.
- Trial name
- NUTRANACRE (NCT05571514)
- Testing
- Mother-of-pearl, Calcium Carbonate
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aging, Physical Fitness
Myogenic and Osteogenic Responses to eXercise and Ibuprofen
The purpose of this study is to determine if the use of ibuprofen blocks the benefits of exercise to build bone and muscle mass.
- Trial name
- MOXI (NCT00462722)
- Testing
- Ibuprofen, musculoskeletal-loading exercise
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Volunteers
Dose-Response of Gonadal Steroids and Bone Turnover in Older Men
The purpose of this study is to determine the levels of testosterone and/or estradiol at which changes in bone turnover, body composition, strength, sexual function etc. begin to occur in older men.
- Trial name
- NCT00114114
- Testing
- Testosterone, Goserelin acetate
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Vertebral Fracture, Osteoporotic Fractures
CCEF in the Treatment of Acute VFFs: Randomized Controlled Trial
in recent years the search for therapeutic protocols that could enhance the VFFs healing, thus reducing bed rest-related complications and improving the quality of life of osteoporotic patients.
- Trial name
- NCT05803681
- Testing
- Capacitive Coupled Electric Fields (CCEF), Calssic clinical protocol
- Volunteers
- 70 people
- Sponsor
- University of Bari Aldo Moro
Healthy Volunteers
Effects of DHEA and Exercise in the Elderly
DHEA or dehydroepiandrosterone is a naturally occurring hormone secreted by tghe adrenal galnds. The secretion of HDEA declines with aging. DHEA is considered a food supplement and it is not regulated by the FDA.
- Trial name
- NCT00205686
- Testing
- DHEA, exercise
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Elderly Volunteers
Effects of Vitamin B3 Derivative Nicotinamide Riboside (NR) in Bone, Skeletal Muscle and Metabolic Functions in Aging
Researchers are trying to determine if the vitamin B3 derivative Nicotinamide Riboside (NR) has any effects in bone, skeletal muscle, and metabolic functions and structure in aging.
- Trial name
- NCT03818802
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes, Hypertension
Evaluation of Exercise Benefits to Promote Health Aging Among Chronically Ill Geriatrics in a Community
The aim of this study is to evaluate the effect of hydraulic resistance circuit training for elderly people with chronic illness.
- Conditions
- Diabetes, Hypertension, Osteoporosis, Osteoarthritis
- Trial name
- NCT01754415
- Testing
- hydraulic resistance circuit training
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
End Stage Renal Failure on Dialysis, Vascular Calcification
Theranova Dialyzer and Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD)
The project will be structured in 3 main parts: 1. Effect of sera of ESRD patients on HD using Theranova dialyzer on high-Pi induced vascular calcification in an in vitro model of rat VSMCs. 2.
- Conditions
- End Stage Renal Failure on Dialysis, Vascular Calcification, Oxidative Stress
- Trial name
- NCT03169400
- Testing
- Theranova dialyzer
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Milan
Deficiency Growth Hormone
Assessment of the Acute Effect of IP
It is a nutraceutical system, consisting of oral tablet and an oral spray called Alpha GPC, which helps your body naturally restore the HGH levels.
- Trial name
- NCT03658187
- Testing
- IP
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Evaluating the Clinical Efficacy of Applying Ultraviolet Photofunctionalization (UV phF) to Standard Titanium Implants Immediately Before Surgery, Monitoring Early Implant Stability and Osseointegration During the Critical Initial Healing Phase
Clinical Assessment of UV Photofunctionalization on Stability and Osseointegration of Early Loaded Implants
The goal of this clinical trial is to learn if UV light treatment (photo functionalization) works to help dental implants heal faster and become stable enough for early use in adults missing teeth in the lower back jaw.
- Conditions
- Evaluating the Clinical Efficacy of Applying Ultraviolet Photofunctionalization (UV phF) to Standard Titanium Implants Immediately Before Surgery, Monitoring Early Implant Stability and Osseointegration During the Critical Initial Healing Phase, Determining the Feasibility and Success Rate of an Accelerated "Early Loading" Protocol, Assessing the Survival Rate of the Implants, Along With the Peri-implant Soft Tissue Response and Marginal Bone Preservation
- Trial name
- UV (NCT07868744)
- Testing
- UV-photofunctionalized titanium dental implants
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Aging
Effects of Resistance Training Programes At Different Intensities on Musculoskeletal, Metabolic, Lipid, Immunological, Inflammatory, Well-being and Functional Parameters in Older Adults.
The aging of the global population is recognized by the World Health Organization (WHO) as a major issue due to the disabilities and comorbidities related to this process, with women being the gender most affected.
- Trial name
- NCT06618469
- Testing
- Elastic band-based resistance training program at high intensity (HI), Elastic band-based resistance training program at moderate-high intensity (MHI-bands), Elastic band-based resistance training program at moderate intensity (MI)
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- University of Valencia
Hypophosphatemia, Rickets
The Impact of Phosphate Metabolism on Healthy Aging
Determine the association between duration and dose of chronic conventional therapy with Pi and renal (nephrocalcinosis/nephrolithiasis), vascular (endothelial function), and cardiovascular function (echo- cardiography) in…
- Conditions
- Hypophosphatemia, Rickets, Hypercalciuria, XLH
- Trial name
- NCT03771105
- Testing
- phosphate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Aging, Frailty
Testosterone Effects on Bone and Frailty
The purpose of this study is to assess the effects of testosterone replacement on bone density, muscle strength, physical performance, quality of life and prostate symptoms in men selected for low bone mineral density or fracture…
- Conditions
- Aging, Frailty, Osteoporosis
- Trial name
- NCT00182871
- Testing
- testosterone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Aging (NIA)
Sarcopenia
The Effects of Long Term Cyclic Testosterone Administration on Muscle Function and Bone in Older Men
The general hypothesis is that administration of testosterone to healthy, older men for 52 weeks (1 year) following a cycle of 4 weeks of testosterone administration and 4 weeks without testosterone (i.e., monthly cycled regimen)…
- Trial name
- NCT01417364
- Testing
- Testosterone enanthate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cardiovascular Diseases, Non-communicable Disease
Effects of Primary Prevention in Elderly People-The Healthy Aging Initiative
The number of elderly will increase rapidly in Europe in the next 30 years, which affects the country's economic and social development, welfare, health care, and also the individuals.
- Trial name
- HAI (NCT03312439)
- Testing
- Given advice
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Aging, Osteoporosis
Determinants of Vitamin K Metabolism
The purpose of this study is to learn how the body responds to different amounts of vitamin K in the diet in order to understand the roles that vitamin K may have in the body.
- Trial name
- NCT00336232
- Testing
- Vitamin K
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Tufts University
Hip Fractures, Aging
Patient Pathway Pharmacist - Optimal Drug-related Care
Medication errors represent the most common cause of patient injury and one of the most frequently reported health related deviation in Norway.
- Conditions
- Hip Fractures, Aging, Patient Fall
- Trial name
- NCT03695081
- Testing
- Patient Pathway Pharmacist intervention
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Sykehuset i Vestfold HF
Hip Fractures, Exercise
Entertainement and Training After a Hip Fracture
Older persons are at riskt for falls and fractures. After hip surgery they are normally treated with physical or occupational therapy.
- Conditions
- Hip Fractures, Exercise, Aging
- Trial name
- ENTERAIN-HF (NCT03515395)
- Testing
- Instruction to a computer game and motivation to use it
- Where
- Switzerland
- Sponsor
- Geriatrische Klinik St. Gallen
Malnutrition, Intellectual Frailty of Aging
Omics4Aging: Stratification of Frailty Population
The overall objective of the study is to stratify a frailty population based on nutrients profiling (amino acids, vitamins, minerals, fatty acids) and metabolic profiling (low molecular weight metabolites in urine and plasma) at…
- Conditions
- Malnutrition, Intellectual Frailty of Aging, Bone Fragility
- Trial name
- ProAge (NCT02572063)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Société des Produits Nestlé (SPN)