Clinical trials: Blood Transfusion Complication
Tranexamic Acid, Blood Loss, Surgical
Do Anesthesiologists Follow Guidelines on Perioperative Use of Tranexamic Acid?
Tranexamic acid has been used to reduce bleeding and transfusion for years. Randomized studies showed its efficacity in orthopedic surgery, trauma and post-partum hemorrhage.
- Conditions
- Tranexamic Acid, Blood Loss, Surgical, Blood Transfusion
- Trial name
- Periop_TXA (NCT05783648)
- Testing
- Use of tranexamic acid
- Where
- Belgium
- Volunteers
- 1,726 people
- Sponsor
- Erasme University Hospital
Liver Transplant; Complications, Bleeding
Viscoelastic Tests-Guided Therapy In Liver Transplantation
BACKGROUND: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation.
- Conditions
- Liver Transplant; Complications, Bleeding, Hemostatic Disorder
- Trial name
- VETLT (NCT03756948)
- Testing
- Usual Care, Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates
- Volunteers
- 237 people
- Sponsor
- Hospital Israelita Albert Einstein
Arthritis of the Hip, Transfusion Related Complications
Preoperative Versus Postoperative Start With Thromboprophylaxis in THA (Total Hip Arthroplasty)
The purpose of this study is to determine if there are differences in clinical events, i.e bleeding with associated morbidity, if thromboprophylaxis with LMWH (Low Molecular Weight Heparin) is initiated before or after surgery.
- Conditions
- Arthritis of the Hip, Transfusion Related Complications, Infection, Wound Discharge
- Trial name
- NCT01714297
- Testing
- dalteparin 5000 IU s.c.
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vestre Viken Hospital Trust
Surgical Blood Loss
Assessment of Hematologic Parameters Before and After Bimaxillary Orthognathic Surgery
The purpose of the present study was to compare some hematologic parameters and operation time in patients who underwent esthetic bimaxillary surgery under hypotensive anesthesia.
- Trial name
- NCT02364765
- Testing
- Remifentanil
- Where
- Brazil
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
General Surgery, Blood Loss, Surgical
Intraoperative Estimated Blood Loss, Blood Transfusion, and Postoperative Clinical Outcomes in Patients Undergoing Non Cardiac Surgery, Siriraj Hospital
After review literature, Siriraj hospital has not unanimous protocol to guide proper preoperative anemia and blood transfusion. This retrospective study will review non-cardiac surgery cases and collect data such as demographic…
- Trial name
- NCT05430659
- Testing
- observational study
- Where
- Thailand
- Volunteers
- 1,268 people
- Sponsor
- Siriraj Hospital
Coronary Artery Disease, Valvular Heart Disease
Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery
This is a single-center, double-blind, randomized controlled trial (RCT) comparing two groups of application of topical dose of tranexamic acid (TxA) versus placebo in patients undergoing coronary artery bypass graft (CABG), off…
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Surgical Blood Loss
- Trial name
- NCT05708690
- Testing
- Tranexamic Acid 100 MG/ML, normal saline
- Where
- Indonesia
- Volunteers
- 132 people
- Sponsor
- Universitas Indonesia
Bleeding, Transfusion Related Complication
Use of Transexamic Acid in Hip Replacement
Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, no to date, no study has been large enough to determine definitively whether the drug is safe…
- Trial name
- NCT02587845
- Testing
- Tranexamic Acid (IV), Tranexamic Acid (Topical)
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Orthopedics, Postoperative Complications
Old Blood and Postoperative Complications
The investigators sought to examine the effects of 'old' red blood cells on mortality and morbidity of patients who undergoing revision hip replacement arthroplasty.
- Conditions
- Orthopedics, Postoperative Complications, Red Blood Cells
- Trial name
- NCT02575820
- Testing
- Old red blood cells transfusion, New red blood cells transfusion
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Anemia
Well Being of Obstetric Patients on Minimal Blood Transfusions
Postpartum haemorrhage (PPH) is one of the top five causes of maternal mortality in developed and developing countries. The most important treatment of PPH is red blood cell (RBC) transfusion.
- Trial name
- WOMB (NCT00335023)
- Testing
- Red blood cell transfusion
- Where
- Netherlands
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sanquin Research & Blood Bank Divisions
Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage
Patient Blood Management for Massive Obstetric Hemorrhage
Obstetric Hemorrhage continues to be the first cause of maternal morbidity and mortality around the world especially in middle to low income countriesThe blood components are high value resources; however, its use has been shown…
- Conditions
- Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage, Fibrinogen; Deficiency, Acquired, Massive Hemorrhage
- Trial name
- NCT03784794
- Testing
- Thromboelastometry, Standard Coagulation Test, Fibrinogen Concentrate Human
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Angel Augusto Perez Calatayud
Disorder Related to Renal Transplantation, Transfusion Reaction
Old Red Blood Cell In Renal Transplantation
Kidney transplantation is the treatment of choice for ESRD. However, the life expectancy of kidney transplant patients is lower than that of the general population.
- Trial name
- ORBIT (NCT02841111)
- Volunteers
- 12,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Anemia, Blood Loss, Surgical
An Observational Study of Blood Management Techniques in Oncology Surgical Treatment
The purpose of this study is to observe the methods used to manage blood loss in surgical procedures to remove tumors from patients with cancer and to determine if there is a relationship with the need for blood transfusions.
- Conditions
- Anemia, Blood Loss, Surgical, Neoplasms
- Trial name
- NCT00264095
- Testing
- Oncological surgery
- Where
- 11 sites in Netherlands
- Volunteers
- 488 people
- Sponsor
- Janssen-Cilag B.V.
Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition, Pre-Term, Pre-Eclampsia
- Trial name
- ChiTwiMC (NCT06414655)
- Where
- 11 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anastomotic Leak, Colorectal Neoplasms
Enhanced Recovery and Patient Blood Management in Colorectal Surgery
To prospectively study the effect of adherence to ERAS and PBM programs on early outcomes after colorectal surgery
- Conditions
- Anastomotic Leak, Colorectal Neoplasms, Blood Transfusion Complication, Colorectal Disorders
- Trial name
- iCral4 (NCT05227014)
- Testing
- Colorectal resection
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Ospedale Sandro Pertini, Roma
Thalassemia, Sickle Cell Anemia
Blood Transfusions in Thalassemia Patients, Complications and Adverse Effects
Patients suffering from Thalassemia or another hemoglobinopathies required regular blood transfusions. The complications and adverse effects of blood transfusions can be classified as immediate and late.
- Trial name
- NCT00971880
- Testing
- Clinical medical record summary
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- HaEmek Medical Center, Israel
Transfusion Reaction
ABTEST© Card Clinical Perfomance Study
The study confirms the performance equivalence of the in vitro Diagnostic reagent ABTEST card used with the new reformulated WS solution
- Trial name
- NCT05140395
- Testing
- ABTEST card
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Diagast
Ovarian Cancer, Perioperative Blood Loss
Comparison of Single-Dose Tranexamic Acid Vs. Placebo in Ovarian Cancer Surgery
This study evaluated the effectiveness of a single dose of tranexamic acid compared to a placebo in reducing blood loss and the need for blood transfusions in women undergoing surgery for ovarian cancer.
- Conditions
- Ovarian Cancer, Perioperative Blood Loss, Blood Transfusion Events
- Trial name
- NCT06879353
- Testing
- Tranexamic Acid (TXA)
- Where
- Pakistan
- Volunteers
- 372 people
- Sponsor
- Sheikh Zayed Medical College
s100b, Hypoxia-Ischemia, Brain
Cord Blood S100B Protein Levels in Neonates Following Intrauterine Transfusions for HDFN-Associated Fetal Anemia
levated levels of S100B protein are a well-established marker of central nervous system (CNS) damage. Fetal anemia resulting from hemolytic disease of the fetus and newborn (HDFN) often necessitates intrauterine transfusions…
- Conditions
- s100b, Hypoxia-Ischemia, Brain, Hemolytic Disease of the Fetus and Newborn, Fetal Anemia
- Trial name
- NCT06984445
- Testing
- Cord blood S100B protein level prior to IUT, Umbilical cord blood gas analysis prior to IUT, Fetal blood count evaluation prior to IUT
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Transfusions, Cystectomy
Robot-assisted Cystectomies With Regard to Blood Loss, Pain and Transfusions.
What influence does robot-assisted surgical treatment in the sense of a radical cystectomy and possibly bladder reconstruction have on blood loss, pain and transfusion requirements? We intend to conduct a corresponding…
- Conditions
- Transfusions, Cystectomy, Blood Loss Requiring Transfusion, Anaemia
- Trial name
- NCT07008261
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Goethe University
Trauma, Blood Transfusion Complication
UltraMTP in Adult Trauma Patients Undergoing Surgery Within 24 Hours: Effects on Mortality and Clinical Outcomes
The purpose of this study is to determine the effects of ultraMTP (>/=30 units pRBC within 24 hours) in trauma patients on mortality and secondary outcomes.
- Conditions
- Trauma, Blood Transfusion Complication, Death
- Trial name
- NCT04866953
- Testing
- Blood transfusion
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Southern California