Clinical trials: Blood Stream Infections
Catheter-related Infections
CATCH - Catheter Infections in Children
Most children admitted to paediatric intensive care units (PICU) need to have medicines given to them into their veins using a narrow tube, so they do not need repeated injections. This tube is called a central venous catheter.
- Trial name
- NCT01029717
- Testing
- Standard polyurethane Central Venous Catheter, Antibiotic impregnated polyurethane CVC (minocycline and rifampicin), Heparin bonded polyurethane CVC
- Where
- United Kingdom
- Volunteers
- 1,859 people
- Sponsor
- Institute of Child Health
Catheter-related Bloodstream Infection
SQ53 Disinfectant Wipes for Prevention of CRBSI
SQ53 is a novel antimicrobial, sporicidal solution that is based on a platform of quaternary ammonium chloride compounds. It has been tested against a wide range of bacteria, viruses, spores and fungal pathogens.
- Trial name
- NCT04822467
- Testing
- SQ53 Wipe, Ethanol Wipe
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- The Cleveland Clinic
Bloodstream Infection, Gram-Negative Infections
The Impact of Fast Antimicrobial Sensitivity Testing Tools on Stewardship Antibiotic and Clinical Outcome (ACT-FAST)
The ACT-FAST study aims to compare commercially available Rapid Antimicrobial Susceptibility Testing (R-AST) tools with the current standard of care for patients with Bloodstream Infections (BSI).
- Conditions
- Bloodstream Infection, Gram-Negative Infections, Gram-Positive Infections, Bacteremia Sepsis
- Trial name
- ACT-FAST (NCT07491419)
- Testing
- Diagnostic Test: Rapid Antimicrobial Susceptibility Testing (R-AST) guided Stewardship, Standard of Care (SOC)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Clinico Humanitas
Upper Extremity Deep Vein Thrombosis
Major Complications Related to PICC and Midline Insertion
Most important peripherally inserted central catheter (PICC) and Midline complications are thrombosis and catheter related blood stream infections.
- Trial name
- PICC/MIDLINE (NCT02489721)
- Testing
- PICC and Midline
- Where
- Italy
- Volunteers
- 547 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Catheter-Related Infections
Peripheral Venous Catheter Related Blood Stream Infections
The aim of this work is to: 1. Study the impact of PIVC skin colonization on catheter tip colonization and the development of CRBSI 2.
- Trial name
- NCT05139628
- Testing
- microbiological identification of samples (skin and blood samples)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ventilator Acquired Pneumonia, Catheter Related Blood Stream Infections
Ontario ICU Clinical Best Practices Demonstration Project
The pragmatic issue at hand how to get physicians and nurses to use best practices… and how to measure consequences of their implementation.
- Conditions
- Ventilator Acquired Pneumonia, Catheter Related Blood Stream Infections, Pressure Ulcer Prophylaxis, DVT Prophylaxis
- Trial name
- NCT00332982
- Testing
- Focused knowledge translation strategies
- Where
- Canada
- Sponsor
- Sunnybrook Health Sciences Centre
End Stage Renal Disease
Analysis of CRBSI Rates in Patients With a NexSite™ HD (Hemodialysis) Catheter
A U.S. multi-centre post approval registry to analyse the CRBSI rate in patients with the NexSite HD Catheter for long term vascular access for hemodialysis.
- Trial name
- NCT02453646
- Testing
- NexSite HD Patients
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Marvao Medical
Salmonella Infections, Infection of Bloodstream
Reservoir of Invasive Salmonellosis in Children, DRC
Bloodstream infections caused by non-typhoid Salmonella (NTS) are a major killing disease in Sub-Saharan Africa. Despite the high case fatality rate, the main reservoir -human, zoonotic or environmental- for invasive NTS rests…
- Trial name
- NCT03073707
- Testing
- Sample collection
- Where
- Democratic Republic of the Congo
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Blood-stream Infections, Salmonella Infection Non-Typhoid
Treating Non-typhoidal Salmonella Bloodstream Infections in Children Under Five in DR Congo: a Cohort Study
With this study the researchers aim to provide observational data on the treatment efficacy of currently used antibiotic treatment regimens for NTS BSI in hospital-admitted children.
- Trial name
- TreNTS (NCT04850677)
- Testing
- Observational Cohort
- Where
- Democratic Republic of the Congo
- Volunteers
- 1,884 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Nosocomial Infections
Multi-center Observational Study to Evaluate Epidemiology and Resistance Patterns of Common ICU-Infections (MOSER)
Most literature on ICU infections and the resistant patterns comes from the western literature. This data may not truly reflect the incidence, epidemiology and resistance patterns in developing countries such as India.
- Trial name
- MOSER (NCT01346735)
- Testing
- No intervention
- Where
- India
- Volunteers
- 381 people
- Sponsor
- Indian Society of Critical Care Medicine
Hemodialysis
Prophylactic Antibiotic Treatment in Hemodialysis
The purpose of this study is to assess the efficacy of prophylactic antibiotic treatment on blood stream infections and severe culture negative infections, in patients on newly started hemodialysis(HD), with a central venous…
- Trial name
- PANTHEM (NCT05248620)
- Where
- 7 sites in Denmark
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
Bacteremia, Sepsis
Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care
Eurobact II will investigate the mortality and morbidity of hospital-acquired blood stream infections in patients treated in intensive care units (ICU).
- Conditions
- Bacteremia, Sepsis, Hospital Acquired Condition, Resistance Bacterial
- Trial name
- EurobactII (NCT03937245)
- Where
- 2 sites in Australia, France
- Volunteers
- 3,058 people
- Sponsor
- Outcome Rea
Hemodialysis Catheter Blood Stream Infection, Central Line Infection
Randomised Controlled Trial of Needle Free Access Devices in Preventing Hemodialysis Blood Stream Infection
This study will be a randomised controlled trial examining whether a new type of needle free access device(TEGO) is associated with less episodes of infection of dialysis lines, when compared to the current gold standard.
- Conditions
- Hemodialysis Catheter Blood Stream Infection, Central Line Infection, Dialysis Line Thrombosis
- Trial name
- TEGO (NCT01082770)
- Testing
- TEGO, Standard
- Where
- Ireland
- Volunteers
- 106 people
- Sponsor
- Beaumont Hospital
Catheter-related Bloodstream Infection (CRBSI) Nos
Clinical Trial Comparing Catheter Lock Solutions TaurolockTMHep 100 and Heparin 100 IE/ml.
The purpose of the investigation is to compare two catheter lock solutions (TaurolockTMHep100 and Heparin 100 IE/ml), on the occurence of catheter related blood stream infection, in patients with intestinal failure and a central…
- Trial name
- NCT01948245
- Testing
- TaurolockTMHep100, Heparin 100 IE/ml
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Palle Bekker Jeppesen
Infection, Heart; Surgery, Heart, Functional Disturbance as Result
Device for Bacteremia Prevention in Post Cardiac Surgical Intensive Care Unit Patients
Intravenous catheters are often placed in large (central) veins in critically ill patients to provide special medications or frequent blood sampling.
- Conditions
- Infection, Heart; Surgery, Heart, Functional Disturbance as Result, Bacteremia
- Trial name
- CHG-Lock™ (NCT03309137)
- Testing
- Chlorhexidine flush
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Alison Fox-Robichaud
Infection
Study of Omiganan 1% Gel in Preventing Catheter Infections/Colonization in Patients With Central Venous Catheters
The purpose of this study is to determine whether treatment with topical omiganan is more effective than treatment with topical povidone-iodine in preventing local catheter site infections and catheter colonization in patients…
- Trial name
- NCT00231153
- Testing
- Omiganan 1% gel, Povidone-Iodine 10%
- Where
- 57 sites in United States, France and 2 more
- Volunteers
- 1,859 people
- Sponsor
- Cadence Pharmaceuticals
Central Line-associated Bloodstream Infection (CLABSI)
Determining the Prevalence of Primary and Secondary Central Line Associated Blood Stream Infection (CLABSI) at the Tertiary Care Hospital
Review key history and clinical examination findings of cases with CLABSI. Microbiological diagnosis and Culture sensitivity tests by automated Bact Alert and Vitek2c systems for CLABSI.
- Trial name
- Microbiology (NCT06458231)
- Testing
- Blood Catheters
- Where
- 2 sites in Egypt
- Volunteers
- 600 people
- Sponsor
- Port Said University