Clinical trials: Blood Component Transfusion
Blood Transfusion; Hemoglobinemia, Hypoxia
The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill
Transfusion of red blood cells is an everyday practice in critical care with the primary aim of restoring adequate tissue oxygenation.
- Conditions
- Blood Transfusion; Hemoglobinemia, Hypoxia, Anemia
- Trial name
- NCT03138200
- Testing
- Blood transfusion
- Where
- 2 sites in Hungary
- Volunteers
- 160 people
- Sponsor
- Szeged University
Erythrocyte Transfusion, Percutaneous Coronary Intervention
The Long-term Clinical Outcomes and Patterns of Transfusion in PCI Patients: Retrospective Cohort Study
A nationwide retrospective cohort study. To investigate the long-term patterns of transfusion and clinical outcomes of patients undergoing PCI.
- Conditions
- Erythrocyte Transfusion, Percutaneous Coronary Intervention, Revascularization
- Trial name
- TFPCI (NCT03776266)
- Testing
- No intervention is required due to retrospective observational study
- Where
- South Korea
- Volunteers
- 48,786 people
- Sponsor
- Samsung Medical Center
Myelodysplastic Syndromes
Lenalidomide Safety/Efficacy in Myelodysplastic Syndromes (MDS) Associated With a Deletion (Del)(5q) Cytogenetic Abnormality
This study is a multicenter, single-arm, open-label study of oral lenalidomide monotherapy administered to red blood cell (RBC) transfusion-dependent subjects with low- or intermediate-1-risk Myelodysplastic Syndromes (MDS)…
- Trial name
- NCT00065156
- Testing
- lenalidomide
- Where
- 32 sites in United States, Germany
- Volunteers
- 148 people
- Sponsor
- Celgene
Wounds and Injuries, Shock, Hemorrhagic
Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and…
- Trial name
- TROOP (NCT05638581)
- Testing
- LTOWB, Components
- Where
- 13 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- University of Alabama at Birmingham
Transfusion Related Complication, Hemodilution
Individualized ANH for Non-cardiac Surgery
In this trial, we proposed an individualized acute normovolemic hemodilution (ANH), and conduct a randomized controlled trial to testify the effect of individualized ANH on red cells requirement for non-cardiac surgeries with…
- Trial name
- NCT06399536
- Testing
- Individualized ANH
- Where
- China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
Meningioma
Magnesium and Intraoperative Blood Loss in Meningioma Surgery
Meningioma is the most common central nervous system tumor and craniotomy with tumor removal was associated with moderate blood loss and blood transfusion.
- Trial name
- NCT03558516
- Testing
- Magnesium group, Normal saline group
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Refractory Cold Agglutinin Disease
Short Course of Bortezomib in Anemic Patients With Refractory Cold Agglutinin Disease
This multicenter, phase II, open label study will enroll patients with chronic cold agglutinin disorder. A single course of Bortezomib will be given at the dose of 1,3 mg/sqm iv on days 1, 4, 8, 11.
- Trial name
- CAD0111 (NCT01696474)
- Testing
- Bortezomib
- Where
- 8 sites in Italy
- Volunteers
- 21 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Burns
Tranexamic Acid in Debridement Surgery of Burns on the Volume of Bleeding in Transfusion Requirements
Tranexamic acid in debridement surgery of burns on the volume of bleeding in transfusion requirements
- Trial name
- NCT05855590
- Testing
- Tranexamic acid, 0.9% isotonic saline solution
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto Mexicano del Seguro Social
Transfusion Dependent Beta Thalassemia
Combination of Thalidomide and Hydroxyuria in Transfusion Dependent Thalasemmia
Beta thalassemia Major (BTM) is the most common hemoglobinopathy caused by mutations in the beta-globin gene . Worldwide, approximately 80 million people carry thalassemia gene mutation.
- Trial name
- Thal-H (NCT07292259)
- Testing
- ADDITION OF THALIDOMIDE AND HYDROXYUREA
- Where
- 9 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- Pakistan Blood and Marrow Transplant (PBMT) Group
Hip Fracture, Anemia
IV Iron in Association With Tranexamic Acid for Hip Fracture
It is a prospective randomized controlled study aiming to test if tranexamic acid combined to intravenous iron before and after surgery for hip fracture in elderly can decrease peri-operative red cell transfusion.
- Trial name
- NCT02428868
- Testing
- tranexamic acid (Exacyl®), intravenous iron (Ferroven®), Saline
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Institut Kassab d'Orthopédie
Anemia
Transfusion Requirements After Orthotopic Liver Transplantation
The objective of this trial is to evaluate different transfusion strategies in patients after liver transplantation. Patients in the experimental arm will be given red blood cell (RBC) transfusion according to a liberal strategy…
- Trial name
- TROLL (NCT01435746)
- Testing
- Red blood cell transfusion
- Where
- Germany
- Sponsor
- University Medical Center Goettingen
Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia
Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia
This clinical trial evaluates the effects of hemoglobin threshold-specific packed red blood cell (PRBC) transfusions on quality of life and functional outcomes in patients who have undergone chemotherapy or an allogeneic…
- Conditions
- Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Myeloid Neoplasm
- Trial name
- NCT06710418
- Testing
- Activity Tracking, Biospecimen Collection, Cognitive Assessment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Upper Gastrointestinal Bleeding, Cirrhosis
Transfusion Requirements in Gastrointestinal (GI) Bleeding
Recently it has been suggested that a restrictive transfusion of units of Red Cells (URC) may improve the outcome of ICU patients with anemia.
- Conditions
- Upper Gastrointestinal Bleeding, Cirrhosis, Portal Hypertension
- Trial name
- NCT00414713
- Testing
- red blood cell transfusion
- Where
- Spain
- Volunteers
- 860 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Red Cell Alloantibodies, Blood Transfusion-Dependent
Evaluation of Micro RNA-155 Expression in Relation to Alloantibody Formation in Transfusion-Dependent Patients
Transfusion-dependent patients, particularly those with β-thalassemia major, require lifelong regular red blood cell (RBC) transfusions to maintain adequate hemoglobin levels and prevent severe anemia.
- Conditions
- Red Cell Alloantibodies, Blood Transfusion-Dependent, Beta Thalassemia
- Trial name
- NCT07480980
- Volunteers
- 100 people
- Sponsor
- Assiut University
High-risk Surgery
Association of Intraoperative Hemodynamic Characteristics to Postoperative Complications and Mortality
Worldwide, about 400 million major surgeries are performed annually. The scarce data available in the literature still suggest high postoperative morbidity and mortality, even in Europe.
- Trial name
- HeCoMo (NCT06355362)
- Volunteers
- 1,000 people
- Sponsor
- Kliniken Essen-Mitte
Blood Transfusion, Cytomegalovirus Infections
Transfusion-Transmitted Cytomegalovirus Prevention in Neonates
To evaluate the capacity of intravenously administered cytomegalovirus (CMV)-immune globin (CMVIG) to immunize high risk premature infants against CMV infections.
- Trial name
- NCT00000584
- Testing
- immunoglobulins
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COVID-19
Safety in Convalescent Plasma Transfusion to COVID-19
There is currently no specific vaccine or treatment to treat critically ill patients with COVID-19. Different therapies are still under investigation and are use in different health institutions, however, a significant proportion…
- Trial name
- NCT04333355
- Testing
- Convalescent Plasma
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- TecSalud Investigación Clínica
Haemolysis Neonatal
Efficacy of Intravenous Immunoglobulin in Management of Rh and ABO Incompatibility Disease
hemolytic disease of newborn is an important cause of hyperbilirubinemia with significant morbidity and mortality in neonatal period. intravenous immunoglobulin has widely used in management of hemolytic disease of new born
- Trial name
- IVIG (NCT03130517)
- Testing
- intravenous immunoglobulin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Anemia, Arthroplasty
Establishment of Optimal Transfusion Threshold After Major Orthopedic Surgery
The purpose of this study is to determine whether a higher threshold for transfusion with red blood cells improves the postoperative ambulation.
- Conditions
- Anemia, Arthroplasty, Replacement, Hip
- Trial name
- NCT00906295
- Testing
- Allowed drop in hemoglobin to 4.5-5.5 mmol/L, Allowed drop in hemoglobin to level between 5.6-6.5 mmol/L
- Where
- 2 sites in Denmark
- Volunteers
- 67 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan