Clinical trials: Blepharoptosis
Lower Eyelid Steatoblepharon (Excess Eyelid Fat)
Phase 2 Study of XAF5 (XOPH5) Ointment for Reduction of Excess Eyelid Fat (Steatoblepharon)
This study will test whether XAF5 (XOPH5) ointment, applied once daily to the lower eyelids for 10 weeks, reduces the prominence of lower eyelid fat in adults with moderate to severe steatoblepharon (excess eyelid fat).
- Trial name
- NCT02230761
- Testing
- XOPH5 Ointment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Topokine Therapeutics, Inc.
Blepharoptosis
A Study in Chinese Patients With Acquired Blepharoptosis
This is a Phase III Study to evaluate the efficacy and safety of STN1013800 Ophthalmic Solution in Chinese Patients with Acquired Blepharoptosis.
- Trial name
- NCT06683651
- Testing
- STN1013800 ophthalmic solution, STN1013800 ophthalmic solution Liquid Base, without STN1013800
- Where
- 23 sites in China
- Volunteers
- 180 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Blepharoptosis
Safety and Efficacy Study of RVL-1201 in Acquired Blepharoptosis
This is an exploratory, proof of concept study to evaluate the safety and efficacy of RVL-1201 dosed once or twice daily for 14 days compared to a placebo (vehicle) control in patients with ptosis.
- Trial name
- NCT01848041
- Testing
- RVL-1201
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Acquired Blepharoptosis
Study of the Safety and Efficacy of RVL-1201 in the Treatment of Acquired Blepharoptosis
This is a Phase 3 study is to evaluate the safety and efficacy of RVL-1201 Ophthalmic Solution in the treatment of acquired blepharoptosis (ptosis) and to assess the safety and comfort of RVL-1201 Ophthalmic Solution for an…
- Trial name
- NCT02436759
- Testing
- RVL-1201
- Where
- 14 sites in United States
- Volunteers
- 140 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Acquired Blepharoptosis
LEV102 Topical Gel in Acquired Blepharoptosis
Phase 1/2a, multicenter, randomized, vehicle-controlled, double-masked, multiple-dose, parallel-group study conducted in adult subjects with acquired blepharoptosis.
- Trial name
- NCT05715346
- Testing
- LEV102 1.0%, LEV102 2.0%, Vehicle
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Levation Pharma, Ltd.
Ptosis, Ptosis, Mild
Performance and Safety Assessment of SPRING THREAD® Elastic Tensor Thread in Patients With Mild to Moderate Facial Ptosis.
The purpose of this post-market clinical follow up study is to assess the safety and effectiveness of the SPRING THREAD® elastic tensor thread.
- Trial name
- ESTES (NCT05746078)
- Where
- 2 sites in France
- Volunteers
- 99 people
- Sponsor
- 1st SurgiConcept
Thymidine Kinase 2 (TK2)
A RETROspective Study of Patients With TK2d
This is a medical chart review study to collect information for patients who have been taking pyrimidine nucleosides for treatment of TK2 deficiency.
- Trial name
- RETRO (NCT03701568)
- Testing
- dC/dT
- Where
- 8 sites in United States, Israel and 1 more
- Volunteers
- 38 people
- Sponsor
- Zogenix MDS, Inc.
Blepharoptosis
Study of Safety of RVL-1201 in Treatment of Blepharoptosis
Phase 3 study to evaluate the extended safety of RVL-1201 compared to placebo for treatment of blepharoptosis. Eligible subjects will be randomized to one of 2 treatment arms.
- Trial name
- NCT03536949
- Testing
- RVL-1201, Vehicle ophthalmic solution
- Where
- 35 sites in United States
- Volunteers
- 234 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Dermatochalasis of Upper Eyelid, Ptosis, Eyelid
Comparative Study of Ziplyft Treatment vs. Traditional Blepharoplasty for Upper Eyelid Rejuvenation
This study will compare two surgery techniques used for upper eyelid (eyelift) surgery: traditional surgery and a newer method called Ziplyft (a non-powered, hand-held clamp).
- Conditions
- Dermatochalasis of Upper Eyelid, Ptosis, Eyelid, Blepharoplasty
- Trial name
- NCT07250139
- Testing
- Ziplyft Device, Comparator Arm: Standard Blepharoplasty
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Osheru Inc.
Blepharoptosis
Study of Safety and Efficacy of RVL-1201 in the Treatment of Blepharoptosis
Phase 3 study to evaluate the safety and efficacy of treatment with RVL-1201 compared to placebo for treatment of blepharoptosis. Eligible subjects will be randomized to one of 2 treatment arms.
- Trial name
- NCT03565887
- Testing
- RVL-1201, Vehicle ophthalmic solution
- Where
- 36 sites in United States
- Volunteers
- 164 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Blepharoptosis
Custom Print Megnetic Levator Prosthesis Pilot Comparison
Study the device feasibility of non-surgical treatment for blepharoptosis (inability to open the eyelid) consisting of a biocompatible magnetic element adhered to the upper eyelid and a second magnet above the eye on a custom…
- Trial name
- NCT04807855
- Testing
- The cMLP device
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Skelmet Inc
Acquired Blepharophimosis
LIDRISE Study: A Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops, Single Dose) in the Treatment of Acquired Blepharoptosis.
A Randomised, Double-Masked, Placebo-Controlled Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops) used twice daily (BID) in the Treatment of Acquired Blepharoptosis
- Trial name
- NCT06514612
- Testing
- STN1013800 (0.1% Oxymetazoline Hydrochloride) eye drops in single dose containers
- Where
- 36 sites in Czechia, France and 7 more
- Volunteers
- 234 people
- Sponsor
- Santen SAS
Blepharoptosis
A Pharmacokinetics (PK) Study in Healthy Adults
This is to characterize STN1013800 active ingredient bioavailability following multiple-dose ocular administration of STN1013800 to both eyes in healthy adults.
- Trial name
- NCT06911216
- Testing
- STN1013800 ophthalmic solution
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Ptosis of the Neck, Mid-face and/or Jowl
A Prospective Study of the NUVANCE Facial Rejuvenation System for Mid-Face, Neck and Jowl Rejuvenation Procedures
The objective of this study is to evaluate the clinical tolerability of the NUVANCE™ Facial Rejuvenation System for correcting neck, mid-face and/or jowl ptosis.
- Trial name
- NCT01100190
- Testing
- NUVANCE Facial Rejuvenation System
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 100 people
- Sponsor
- Ethicon, Inc.
Dacryocystorhinostomy, Ectropion
PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery
The aim of this study is to show that the performance of Novosyn® Quick suture material is comparable with standard suture material used in Ophthalmic surgery.
- Conditions
- Dacryocystorhinostomy, Ectropion, Entropion, Ptosis
- Trial name
- OPHTHALNOQ (NCT02761083)
- Testing
- Novosyn® Quick, Vicryl® Rapid
- Where
- Spain
- Sponsor
- Aesculap AG