Clinical trials: Blepharitis
Blepharitis
The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Four-Week Treatment Period (P08638)
The objective of this study is to compare the safety and efficacy of azithromycin ophthalmic solution, 1% versus placebo over a four-week treatment period.
- Trial name
- NCT00894530
- Testing
- Azithromycin ophthalmic solution, 1%
- Where
- 26 sites in United States
- Volunteers
- 314 people
- Sponsor
- Merck Sharp & Dohme LLC
Meibomian Gland Dysfunction, Blepharitis
Comparison Between Continuous and Pulsed Oral Doxycycline Treatment Protocols for Refractory Meibomian Gland Dysfunction
The goal of this observational study (spontaneous, non-randomised, prospective cohort, phase IV) is to compare the efficacy and safety of two different oral doxycycline treatment protocols (LCP - Low dose continuous protocol \&…
- Conditions
- Meibomian Gland Dysfunction, Blepharitis, Doxycycline Adverse Reaction
- Trial name
- NCT06520007
- Testing
- Doxycyclin
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- University of Milan
Blepharitis
0.01% Hypochlorous Acid in the Treatment of Blepharitis
This is a multi-center, multidisciplinary, open-label, randomized controlled prospective clinical study.
- Trial name
- NCT05608980
- Testing
- 0.01% hypochlorous acid
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Xerophthalmia, Blepharitis
Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes
Systane Ultra is at least as efficacious and safe as Refresh Tears in Asian people with Dry Eyes
- Trial name
- NCT00796926
- Testing
- Systane Ultra eyedrops, Refresh eye drops
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Louis Tong
Demodex Blepharitis
Impact of XDEMVY® on Demodex Blepharitis in Soft Contact Lens Wearers
To compare the efficacy of XDEMVY ophthalmic drop to its vehicle control for the treatment of Demodex blepharitis and its impact on the soft contact lens wearing experience.
- Trial name
- Ariel (NCT06182358)
- Testing
- Lotilaner ophthalmic solution, 0.25%, Vehicle control
- Where
- 14 sites in United States
- Volunteers
- 145 people
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Demodex Blepharitis
Demodex Blepharitis in Scleral Lens Wearers
The purpose of this study will be to see if Xdemvy (lotilaner ophthalmic solution) 0.25% has a positive impact on ocular surface symptoms and PROSE device functionality and performance.
- Trial name
- NCT07561450
- Testing
- Xdemvy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Boston Sight
Blepharitis
A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Vehicle in Subjects With Blepharitis (P08636)
The purpose of this study is to compare the safety and efficacy of azithromycin ophthalmic solution, 1% versus vehicle over a four-week treatment period in treating the signs and symptoms of subjects with blepharitis and to…
- Trial name
- NCT01269658
- Testing
- Azithromycin ophthalmic solution, 1%, Vehicle
- Volunteers
- 40 people
- Sponsor
- Merck Sharp & Dohme LLC
Blepharitis
Probiotics for Blepharitis in Adults and Children
The alteration of the intestinal microbiota through the use of specific probiotics can improve the clinical course of blepharitis by restoring intestinal and immune homeostasis.
- Trial name
- NCT04742855
- Testing
- Probiotics
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Molise
Chronic Blepharitis
Treatment of Demodex Blepharitis With Ivermectin Gel 0.1% Plus Metronidazole 1%
Blepharitis is a endemic inflammatory disease caused mainly by Demodex folliculorum and Demodex Brevis, This mites are often associated with anaerobic bacteria that produces a skin inflammation, so a intervention that reduces the…
- Trial name
- NCT02236403
- Testing
- Ivermectin 0.1% Metronidazole 1%, None intervention
- Where
- Colombia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Dry Eye Syndrome
A Prospective Clinical Study Assessing the Effects of Tetracycline Antibiotic on Tear Film and Tear Lipid Composition Within a Population of Patients Diagnosed With Blepharitis and Dry Eye Disease
The purpose of this research project is to determine the effects of oral tetracycline such as Minocycline (Minocin) on tear film composition and tear lipid (meibomian gland secretions) characteristics in patients with chronic…
- Trial name
- NCT00355459
- Testing
- Tetracycline: Doxycycline analog
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Blepharitis
Safety and Efficacy of TP-03 for the Treatment of Demodex Blepharitis
The purpose of this study is to compare the safety and efficacy of TP-03, 0.25%, an eyedrop, to its vehicle control for the treatment of blepharitis due to Demodex, a microscopic mite frequently found in human hair follicles.
- Trial name
- Saturn-1 (NCT04475432)
- Testing
- TP-03, 0.25%, TP-03 Vehicle
- Where
- 15 sites in United States
- Volunteers
- 421 people
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Dry Eye Syndromes, Meibomian Gland Dysfunction
Photobiomodulation With REd vs BluE Light (REBEL)
The use of photobiomodulation or low-level light therapy (LLLT) in the ophthalmic field stemmed from dermatology which has shown impact on skin blood flow and regeneration.
- Conditions
- Dry Eye Syndromes, Meibomian Gland Dysfunction, Blepharitis
- Trial name
- NCT06371300
- Testing
- Red LLLT, Blue LLLT
- Where
- 2 sites in New Zealand, United Kingdom
- Volunteers
- 36 people
- Sponsor
- Aston University
Dry Eye, Dry Eye Syndrome
DRy Eye Outcome and Prescription Study
The DRy eye Outcome and Prescription Study (DROPS) is a large observational multicentre study exploring the 'real world' effectiveness of artificial tears in dry eye disease and determinants of efficacy.
- Conditions
- Dry Eye, Dry Eye Syndrome, Blepharitis, Meibomian Gland Dysfunction
- Trial name
- DROPS (NCT03652415)
- Testing
- Artificial tears (classified by MHRA as a medical device)
- Where
- 2 sites in United Kingdom
- Volunteers
- 635 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Meibomian Gland Dysfunction, Demodex Infestation of Eyelid
Effect of an Exploratory Vehicle on Meibomian Gland Dysfunction in Patients With Demodex
The purpose of this study is to evaluate and compare the effect of two dosing regimens, BID versus TID dosing, of an Exploratory Vehicle (EV) on meibomian gland dysfunction (MGD) in patients with Demodex lid infestation.
- Conditions
- Meibomian Gland Dysfunction, Demodex Infestation of Eyelid, Blepharitis, Demodectic Blepharitis
- Trial name
- Rhea (NCT06054217)
- Testing
- Vehicle of TP-03
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Blepharitis
Study Evaluating the Safety and Efficacy of NCX 4251 Ophthalmic Suspension for the Treatment of Blepharitis
This is a multi-center, randomized, double-masked, placebo-controlled, Phase 2b trial evaluating the safety and efficacy of NCX 4251 (fluticasone propionate nanocrystal) Ophthalmic Suspension 0.1% QD for the treatment of acute…
- Trial name
- Mississippi (NCT04675242)
- Testing
- NCX 4251
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Nicox Ophthalmics, Inc.
Corneal Infiltrates
A Phase II Study of Moxidex Ophthalmic Solution for Treatment of Marginal Corneal Infiltrates
The purpose of the study is to determine whether Moxidex ophthalmic solution is safe and effective in treating marginal corneal infiltrates.
- Trial name
- NCT00579020
- Testing
- Moxifloxacin/dexamethasone phosphate ophthalmic solution, Moxifloxacin ophthalmic solution 0.5%, Dexamethasone phosphate solution, 0.1%
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Alcon Research
Demodex Blepharitis, Meibomian Gland Dysfunction (MGD)
Effectiveness of Low Level Light Therapy and Intense Pulse Light on Mite Count as Adjuntive Therapies in Demodex Blepharitis Using Artificial Intelligent Program (Ai-Demodex)
Primary Objective: To evaluate the efficacy of LLLT, IPL, and IPL + LLLT in re ducing demodex count in patients with Demodex Blepharitis.
- Trial name
- Ai-Demodex (NCT07169461)
- Testing
- The blue MY MASK-E, IPL, Mechanical with pharmacological treatment
- Where
- Thailand
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Meibomian Gland Dysfunction, Blepharitis
Pilot Study Comparing the Safety and Efficacy of Two Dosing Regimens of TP-03 for the Treatment of MGD
The purpose of this study is to compare the safety and efficacy of TP-03, 0.25%, an eyedrop, BID vs TID dosing regimens for the treatment of meibomian gland dysfunction in patients with Demodex lid infestation.
- Conditions
- Meibomian Gland Dysfunction, Blepharitis, Demodex Infestation
- Trial name
- Ersa (NCT05454956)
- Testing
- TP-03, TP-03 Vehicle
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Blepharitis
A Phase 2, Controlled, Double Blind, Randomized and Multicenter Study to Compare Efficacy and Safety of a Novel Topical Therapy (APT-001, Spinosad 1.8%) in Patients With Blepharitis.
The purpose of this study is to establish the clinical efficacy of APT-001 topical therapy 1.8% in patients with blepharitis as compared to its vehicle control, and to establish that the therapeutic is safe and generally well…
- Trial name
- VISTA-1 (NCT06720896)
- Testing
- APT-001 topical ophthalmic ointment (spinosad), Vehicle control for APT-001 topical ophthalmic ointment
- Where
- 2 sites in Guatemala
- Volunteers
- 66 people
- Sponsor
- Aperta Biosciences, LLC
Blepharitis, Dry Eye Syndrome
Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery
The purpose of this pilot feasibility study is to assess whether treating meibomian gland dysfunction (MGD) prior to cataract surgery helps promote meibomian gland function, visual quality and ocular comfort after cataract…
- Trial name
- NCT01808560
- Testing
- LipiFlow Pre-Treatment, LipiFlow Post-treatment
- Where
- 7 sites in United States
- Volunteers
- 34 people
- Sponsor
- TearScience, Inc.